{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:27:38Z","timestamp":1787772458085,"version":"build-2784847793"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>Ozone is a strong oxidizing agent, capable of promoting therapeutic effects such as antimicrobial, anti inflammatory, antioxidant and healing activities, with low probability of toxicity when used in a specific dosage range. The aim of this study was to conduct a literature review to assess clinical trials available over the past 10 years regarding the effectiveness and safety of ozone therapy to treat dermatological disorders. The search for bibliographic material was carried out through PubMed, Cochrane Library and Google Scholar electronic databases. The inclusion criteria covered only controlled clinical trials published from 2011 to 2021 and written in English. The 18 selected clinical trials included 1279 patients (ranging from 12 to 400 patients per study), of which 1185 patients were adults and 94 were children. Ozone therapy was evaluated regarding the treatment of diabetic foot ulcers, digital ulcers, chronic venous leg ulcers, atopic dermatitis, skin burns, onychomycosis, tinea pedis, cutaneous leishmaniasis, balanitis xerotica obliterans and multiple common warts. Only three studies, addressing the treatment of cutaneous leishmaniasis, skin ulcers and skin burns, evidenced lack of effectiveness of ozone treatment. Mild adverse effects occurred in three clinical trials, whereas severe side effects occurred in only one clinical trial, regarding skin ulcers. Therefore, ozone therapy may be suggested as an alternative or complementary treatment in some types of dermatological conditions specially affecting refractory patients. Though, a greater number of high-quality clinical trials is needed to clearly establish the safety of ozone therapy in dermatological disorders.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijd.ijd_152_22","type":"journal-article","created":{"date-parts":[[2024,5,29]],"date-time":"2024-05-29T12:13:57Z","timestamp":1716984837000},"page":"479","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":21,"title":["Effectiveness and Safety of Ozone Therapy for Dermatological Disorders"],"prefix":"10.4103","volume":"67","author":[{"given":"Andressa Urbano","family":"Machado","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata Vidor","family":"Contri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-54-20240829","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1007\/s10753-020-01184-2","article-title":"Anti-inflammatory effect of ozone therapy in an experimental model of rheumatoid arthritis","volume":"43","author":"Tartari","year":"2020","journal-title":"Inflammation"},{"key":"R2-54-20240829","first-page":"65873","article-title":"Antioxidant mechanism is involved in the gastroprotective effects of ozonized sunflower oil in ethanol-induced ulcers in rats","volume":"2007","author":"Rodr\u00edguez","year":"2007","journal-title":"Mediators Inflamm"},{"key":"R3-54-20240829","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.ijpharm.2013.09.039","article-title":"Ozonated oils as functional dermatological matrices: Effects on the wound healing process using SKH1 mice","volume":"458","author":"Valacchi","year":"2013","journal-title":"Int J Pharm"},{"key":"R4-54-20240829","first-page":"1537","article-title":"Determination of effect on cutaneous wound healing of ozonated hazelnut oil","volume":"2","author":"O\u011fuzkan","year":"2018","journal-title":"Proceedings"},{"key":"R5-54-20240829","doi-asserted-by":"crossref","first-page":"48","DOI":"10.4081\/ozone.2018.7971","article-title":"Microbiological aspects of ozone: Bactericidal activity and antibiotic\/antimicrobial resistance in bacterial strains treated with ozone","volume":"3","author":"Giuliani","year":"2018","journal-title":"Ozone Ther"},{"key":"R6-54-20240829","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1080\/01919512.2013.862165","article-title":"In vitro inactivation of Herpes virus by ozone","volume":"36","author":"Petry","year":"2014","journal-title":"Ozone Sci Eng"},{"key":"R7-54-20240829","first-page":"670","article-title":"Antifungal activity of ozonized olive oil (Oleozone)","volume":"8","author":"Geweely","year":"2006","journal-title":"Int J Agric Biol"},{"key":"R8-54-20240829","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.exppara.2008.10.009","article-title":"Giardia duodenalis: Effects of an ozonized sunflower oil product (Oleozon) on in vitro trophozoites","volume":"121","author":"Hern\u00e1ndez","year":"2009","journal-title":"Exp Parasitol"},{"key":"R9-54-20240829","doi-asserted-by":"crossref","first-page":"163","DOI":"10.4103\/2045-9912.266997","article-title":"Clinical utility of ozone therapy in dental and oral medicine","volume":"9","author":"Suh","year":"2019","journal-title":"Med Gas Res"},{"key":"R11-54-20240829","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1097\/JOM.0000000000001042","article-title":"Ozone-related respiratory morbidity in a low-pollution region","volume":"59","author":"Magzamen","year":"2017","journal-title":"J Occup Environ Med"},{"key":"R12-54-20240829","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s12940-018-0384-z","article-title":"Susceptibility to short-term ozone exposure and cardiovascular and respiratory mortality by previous hospitalizations","volume":"17","author":"Raza","year":"2018","journal-title":"Environ Heal"},{"key":"R13-54-20240829","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.ijbiomac.2007.06.010","article-title":"A physicochemical investigation on the effects of ozone on blood","volume":"41","author":"Travagli","year":"2007","journal-title":"Int J Biol Macromol"},{"key":"R14-54-20240829","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.ejphar.2014.08.029","article-title":"Is ozone pre-conditioning effect linked to Nrf2\/EpRE activation pathway in vivo? 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Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ijd.ijd_152_22","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T18:48:03Z","timestamp":1787770083000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ijd.ijd_152_22"}},"subtitle":["A Literature Review of Clinical Trials"],"short-title":[],"issued":{"date-parts":[[2022,7]]},"references-count":33,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.4103\/ijd.ijd_152_22","relation":{},"ISSN":["0019-5154"],"issn-type":[{"value":"0019-5154","type":"print"}],"subject":[],"published":{"date-parts":[[2022,7]]}}}