{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:39:34Z","timestamp":1787071174217,"version":"build-2736575974"},"reference-count":5,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:p>Acanthosis nigricans (AN) describes clinically hyperpigmented skin, which most commonly affects the flexural areas such as axilla, groin and neck. It is usually a benign condition associated with obesity, insulin resistance, and hyperinsulinemia; endocrinopathy; or malignancy, in particular, gastrointestinal adenocarcinoma. It can also occur in association with various genetic syndromes involving various organ systems. Few such known syndromes are Berardinelli-Seip syndrome, Alstr\u00f6m syndrome, Leprechaunism, and Bardet-Biedl syndrome. MORFAN syndrome, which associates mild mental retardation, pre- and post-natal overgrowth, remarkable facies and diffuse and widespread AN, is a rare entity.<\/jats:p>","DOI":"10.4103\/ijd.ijd_160_19","type":"journal-article","created":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T05:11:28Z","timestamp":1559020288000},"page":"231-234","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["MORFAN Syndrome: A Rarity but a Reality!"],"prefix":"10.4103","volume":"64","author":[{"given":"Gourab","family":"Roy","sequence":"first","affiliation":[{"name":"From the Department of Dermatology, Institute of Post Graduate Medical Education and Research and SSKM Hospital, Bhowanipore, Kolkata, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumit","family":"Sen","sequence":"additional","affiliation":[{"name":"From the Department of Dermatology, Institute of Post Graduate Medical Education and Research and SSKM Hospital, Bhowanipore, Kolkata, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shreya","family":"Poddar","sequence":"additional","affiliation":[{"name":"From the Department of Dermatology, Institute of Post Graduate Medical Education and Research and SSKM Hospital, Bhowanipore, Kolkata, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20250921","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0190-9622(94)70128-8","article-title":"Acanthosis nigricans","volume":"31","author":"Schwartz","year":"1994","journal-title":"J Am Acad Dermatol"},{"key":"R2-20250921","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1111\/j.0736-8046.2004.21323.x","article-title":"Generalized acanthosis nigricans in childhood","volume":"21","author":"Inamdar","year":"2004","journal-title":"Pediatr Dermatol"},{"key":"R3-20250921","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1002\/ajmg.1320450424","article-title":"Morfan: A new syndrome characterized by mental retardation, pre-and postnatal overgrowth, remarkable face and acanthosis nigricans in 5-year-old boy","volume":"45","author":"Seemanov\u00e1","year":"1993","journal-title":"Am J Med Genet"},{"key":"R4-20250921","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.jpeds.2015.04.069","article-title":"MORFAN syndrome: An infantile hypoinsulinemic hypoketotic hypoglycemia due to an AKT2 mutation","volume":"167","author":"Garg","year":"2015","journal-title":"J Pediatr"},{"key":"R5-20250921","first-page":"E20","article-title":"A case of MORFAN syndrome","volume":"95","author":"Bryan","year":"2015","journal-title":"Cutis"}],"container-title":["Indian Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00076423-201964030-00011","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:42:34Z","timestamp":1787067754000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00076423-201964030-00011"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5]]},"references-count":5,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019]]}},"URL":"https:\/\/doi.org\/10.4103\/ijd.ijd_160_19","relation":{},"ISSN":["0019-5154","1998-3611"],"issn-type":[{"value":"0019-5154","type":"print"},{"value":"1998-3611","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5]]},"assertion":[{"value":"2019-03-01","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-03-01","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}