{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:23:09Z","timestamp":1787772189201,"version":"build-2784847793"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Vitiligo, a multifactorial, depigmented skin disease, is characterised by selective loss of functional melanocytes leading to pigment reduction in the affected areas of the skin.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>We aimed to examine thiol-disulphide homeostasis, IMA, copper, zinc, selenium, vitamin A and vitamin C levels in vitiligo patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>The study included 83 vitiligo patients and 72 healthy controls. Copper, zinc, and selenium levels were measured by atomic absorption spectrophotometer; vitamin A and E levels were measured by high-performance liquid chromatography. Ischemia-modified albumin and native\/total thiol levels were measured by colourimetric method.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Serum native and total thiol levels were significantly lower in vitiligo patients (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001, for all). Zn levels were significantly higher in vitiligo patients than in the control group (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.004). There was no statistical difference in terms of Cu, Se, vitamin A and vitamin E levels.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>All thiol-disulphide homeostasis parameters (the most important antioxidant\u2013oxidant system in circulation), trace elements, and vitamins together were evaluated in the present study in vitiligo patients. It can be concluded that vitiligo patients have increased oxidative stress status, and also the increase in the dissemination of the disease also increases the oxidative stress in the body.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijd.ijd_169_23","type":"journal-article","created":{"date-parts":[[2024,5,15]],"date-time":"2024-05-15T02:26:16Z","timestamp":1715739976000},"page":"487-492","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":6,"title":["Thiol-Disulphide Homeostasis, Ischemia-Modified Albumin, Trace Elements and Vitamins in Vitiligo Patients"],"prefix":"10.4103","volume":"68","author":[{"given":"Esra Firat","family":"O\u011fuz","sequence":"first","affiliation":[{"name":"From the Department of Clinical Biochemistry, Ankara City Hospital, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yildiz","family":"Hayran","sequence":"additional","affiliation":[{"name":"From the Department of Dermatology, Ankara City Hospital, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c7i\u011fdem","family":"Y\u00fccel","sequence":"additional","affiliation":[{"name":"From the Department of Clinical Biochemistry, G\u00fclhane Training and Research Hospital, University of Health Sciences, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Funda","family":"Eren","sequence":"additional","affiliation":[{"name":"From the Department of Clinical Biochemistry, Ankara City Hospital, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murat","family":"Kizilg\u00fcn","sequence":"additional","affiliation":[{"name":"From the Department of Clinical Biochemistry, G\u00fclhane Training and Research Hospital, University of Health Sciences, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d6zcan","family":"Erel","sequence":"additional","affiliation":[{"name":"From the Department of Clinical Biochemistry, Ankara City Hospital, Ankara, Turkey"},{"name":"From the Department of Biochemistry, Y\u0131ld\u0131r\u0131m Beyaz\u0131t University, Faculty of Medicine, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20240829","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1159\/000506103","article-title":"Vitiligo: A Review","volume":"236","author":"Bergqvist","year":"2020","journal-title":"Dermatology"},{"key":"R2-20240829","first-page":"CD003263","article-title":"Interventions for vitiligo","author":"Whitton","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"key":"R3-20240829","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.det.2016.11.013","article-title":"Genetics of Vitiligo","volume":"35","author":"Spritz","year":"2017","journal-title":"Dermatol Clin"},{"key":"R4-20240829","doi-asserted-by":"crossref","first-page":"498","DOI":"10.5114\/ada.2018.72856","article-title":"Dynamic thiol\/disulphide homeostasis in vitiligo patients","volume":"35","author":"Aksoy","year":"2018","journal-title":"Postepy Dermatol Alergol"},{"key":"R5-20240829","doi-asserted-by":"crossref","first-page":"132","DOI":"10.3126\/kumj.v12i2.13660","article-title":"Comparison of oxidant-antioxidant status in patients with vitiligo and healthy population","volume":"12","author":"Agrawal","year":"2014","journal-title":"Kathmandu Univ Med J (KUMJ)"},{"key":"R6-20240829","doi-asserted-by":"crossref","first-page":"921","DOI":"10.3906\/sag-2011-139","article-title":"A sensitive indicator for the severity of COVID-19: Thiol","volume":"51","author":"Erel","year":"2021","journal-title":"Turk J Med Sci"},{"key":"R7-20240829","doi-asserted-by":"crossref","first-page":"439","DOI":"10.2217\/bmm-2016-0259","article-title":"Usefulness of ischemia-modified albumin in predicting oxidative stress in patients with vitiligo","volume":"11","author":"Ata\u015f","year":"2017","journal-title":"Biomark Med"},{"key":"R8-20240829","doi-asserted-by":"crossref","first-page":"295","DOI":"10.18231\/j.ijced.2019.062","article-title":"Study on trace elements levels in vitiligo and normal subjects","volume":"5","author":"Praneeth","year":"2019","journal-title":"IP Indian J Clin Exp Dermatol"},{"key":"R9-20240829","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/j.1749-6632.1992.tb17085.x","article-title":"Antioxidant functions of vitamins. 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