{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T17:10:16Z","timestamp":1788887416697,"version":"build-2803163510"},"reference-count":19,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","license":[{"start":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T00:00:00Z","timestamp":1788134400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Epidermolysis bullosa (EB) is a rare inherited genodermatosis that affects both the skin and gastrointestinal tract, potentially leading to altered gut microbiota. This study aimed to assess the diversity and composition of the gut microbiome in EB patients compared to healthy controls. Twelve EB patients\u2014six with dystrophic epidermolysis bullosa patients (pDEB) and six with nondystrophic epidermolysis bullosa patients (pNDEB)\u2014and 12 age- and gender-matched healthy controls were included. Fecal samples were collected, and 16S rRNA gene sequencing (V3\u2013V4 region) was performed. Alpha diversity indices revealed a significant reduction in gut microbiota richness in EB patients, particularly in pNDEB, compared to controls. Beta diversity analysis using unweighted UniFrac showed compositional differences between groups, while weighted UniFrac and principal coordinate analysis revealed overlapping clustering patterns. Genus-level comparisons indicated lower relative abundance of\n                    <jats:italic toggle=\"yes\">Staphylococcus, Corynebacterium,<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">Prevotella<\/jats:italic>\n                    in EB subgroups. These findings suggest that EB is associated with gut microbiota dysbiosis, warranting further investigation into its potential clinical implications and microbial biomarkers.\n                  <\/jats:p>","DOI":"10.4103\/ijd.ijd_191_25","type":"journal-article","created":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T15:20:03Z","timestamp":1776784803000},"page":"420-420","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Alterations in Gut Microbiome Diversity and Composition in Patients with Epidermolysis Bullosa: A Case-Control Study"],"prefix":"10.4103","volume":"71","author":[{"given":"Suci","family":"Widhiati","sequence":"first","affiliation":[{"name":"From the Department of Dermatology and Venereology, Faculty of Medicine, Universitas Sebelas Maret\/RSUD Dr. Moewardi, Surakarta, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hardyanto","family":"Soebono","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dewajani","family":"Purnomosari","sequence":"additional","affiliation":[{"name":"Department of Histology and Cell Biology, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tri","family":"Wibawa","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,8,31]]},"reference":[{"key":"R1-20260908","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1196\/annals.1415.017","article-title":"Epidermolysis bullosa: A genetic disease of altered cell adhesion and wound healing, and the possible clinical utility of topically applied thymosin beta4","author":"Fine","year":"2007","journal-title":"Ann N Y Acad Sci"},{"key":"R2-20260908","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1111\/j.1525-1470.1988.tb00879.x","article-title":"Nutritional and metabolic profile of children with epidermolysis bullosa","volume":"5","author":"Lechner-Gruskay","year":"1988","journal-title":"Pediatr Dermatol"},{"key":"R3-20260908","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1016\/0140-6736(92)92759-9","article-title":"Oral and gastrointestinal manifestations of epidermolysis bullosa","volume":"340","author":"Travis","year":"1992","journal-title":"Lancet"},{"key":"R4-20260908","first-page":"14","article-title":"Yang, Kashyap PC. 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