{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:39:27Z","timestamp":1787071167062,"version":"build-2736575974"},"reference-count":18,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,9]]},"abstract":"Abstract<\/jats:title>\n \n Background:<\/jats:title>\n Vulvovaginal candidiasis (VVC) is a prevalent form of vaginitis, and most patients show improvement when treated with antifungal medications. However, recurrence may affect a minority. It has been found through previous research that the concomitant utilisation of probiotics during acute VVC leads to early relief of symptoms and signs and offers a preventive measure against recurrences.<\/jats:p>\n <\/jats:sec>\n \n Objectives:<\/jats:title>\n This study aimed to assess the efficacy of the combination of oral probiotics with conventional antifungal treatment as compared to conventional antifungal treatment alone.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n \n Sixty patients who were newly diagnosed with VVC were enrolled in a randomised controlled trial. They were divided into two groups. Group A included 30 cases treated with conventional antifungal medication (oral fluconazole 150 mg single dose), while Group B included 30 cases treated with conventional antifungal medication (oral fluconazole 150 mg single dose) alongside oral probiotic capsules (\n Lactobacillus rhamnosus<\/jats:italic>\n ,\n L. crispatus<\/jats:italic>\n ,\n L. gasseri<\/jats:italic>\n ,\n L. jensenii<\/jats:italic>\n ) for 2 months. The clinical and mycological findings were recorded before and after treatment. The relapse rate and side effects were recorded during the period of our study.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n No significant difference between the clinical cure rate, mycological cure, and relapse rate was seen between the two groups. (\n P<\/jats:italic>\n < 0.05). However, a larger proportion of patients in Group B (97%) achieved complete remission compared to Group A (90%). No side effects were noted in either of the groups.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n Based on the findings, it can be concluded that the addition of probiotics to conventional antifungal treatment led to better rates of clinical and mycological cure and a lower likelihood of relapse compared to conventional antifungal treatment alone.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/ijd.ijd_193_24","type":"journal-article","created":{"date-parts":[[2024,10,30]],"date-time":"2024-10-30T11:52:33Z","timestamp":1730289153000},"page":"422-422","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":5,"title":["Role of Probiotic in Vulvovaginal Candidiasis: A Randomised Controlled Non-blinded Trial from India"],"prefix":"10.4103","volume":"69","author":[{"given":"Apaopa Jemima","family":"Thekho","sequence":"first","affiliation":[{"name":"From the Department of Dermatology and STD, Lady Hardinge Medical College and Sucheta Kriplani Hospital, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vibhu","family":"Mendiratta","sequence":"additional","affiliation":[{"name":"From the Department of Dermatology and STD, Lady Hardinge Medical College and Sucheta Kriplani Hospital, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taru","family":"Garg","sequence":"additional","affiliation":[{"name":"From the Department of Dermatology and STD, Lady Hardinge Medical College and Sucheta Kriplani Hospital, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravinder","family":"Kaur","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Lady Hardinge Medical College and Sucheta Kriplani Hospital, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vidya","family":"Yadav","sequence":"additional","affiliation":[{"name":"From the Department of Dermatology and STD, Lady Hardinge Medical College and Sucheta Kriplani Hospital, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,10,29]]},"reference":[{"key":"R1-20241101","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0020-7292(00)00350-7","article-title":"Vaginal candidosis: Epidemiological and etiological factors","volume":"71","author":"Ferrer","year":"2000","journal-title":"Int J Gynaecol Obstet"},{"key":"R2-20241101","first-page":"757","article-title":"Vulvovaginal candidiasis: Clinical manifestations, risk factors, management algorithm","volume":"92","author":"Eckert","year":"1998","journal-title":"Obstet Gynecol"},{"key":"R3-20241101","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1080\/713683045","article-title":"\u2018You don't really feel you can function normally\u2019: Women's perceptions and personal management of vaginal thrush","volume":"18","author":"Chapple","year":"2000","journal-title":"J Reprod Infant Psychol"},{"issue":"4_suppl","key":"R4-20241101","first-page":"3","article-title":"Candidal vaginitis: Natural history, predisposing factors and prevention","volume":"70","author":"Morton","year":"1977","journal-title":"Proc R Soc Med"},{"key":"R5-20241101","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1093\/clinids\/12.2.258","article-title":"Application of DNA typing methods to Candida albicans epidemiology and correlations with phenotype","volume":"12","author":"Stevens","year":"1990","journal-title":"Rev Infect Dis"},{"key":"R6-20241101","doi-asserted-by":"crossref","first-page":"019301","DOI":"10.1136\/bmjopen-2017-019301","article-title":"Probiotics administered intravaginally as a complementary therapy combined with antibiotics for the treatment of bacterial vaginosis: A systematic review protocol","volume":"7","author":"Ma","year":"2017","journal-title":"BMJ 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antimicrobial metronidazole therapy of bacterial vaginosis with oral probiotic lactobacillus rhamnosus GR-1 and lactobacillus reuteri RC-14: Randomized, double-blind, placebo controlled trial","volume":"8","author":"Anukam","year":"2006","journal-title":"Microbes Infect"},{"key":"R11-20241101","doi-asserted-by":"crossref","first-page":"084","DOI":"10.1093\/femsec\/fiaa084","article-title":"Effect of oral consumption of capsules containing lactobacillus paracasei LPC-S01 on the vaginal microbiota of healthy adult women: A randomized, placebo-controlled, double-blind crossover study","volume":"96","author":"Koirala","year":"2020","journal-title":"FEMS Microbiol Ecol"},{"key":"R12-20241101","doi-asserted-by":"crossref","first-page":"3859","DOI":"10.3390\/ijerph16203859","article-title":"Probiotics for the treatment of bacterial vaginosis: A meta-analysis","volume":"16","author":"Wang","year":"2019","journal-title":"Int J Environ Res Public Health"},{"key":"R13-20241101","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1111\/j.1472-765X.2008.02477.x","article-title":"Improved treatment of vulvovaginal candidiasis with fluconazole plus probiotic lactobacillus rhamnosus GR 1 and lactobacillus reuteri RC 14","volume":"48","author":"Martinez","year":"2009","journal-title":"Lett Appl Microbiol"},{"key":"R14-20241101","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.micinf.2010.04.010","article-title":"Lactic acid bacteria colonization and clinical outcome after probiotic supplementation in conventionally treated bacterial vaginosis and vulvovaginal candidiasis","volume":"12","author":"Ehrstr\u00f6m","year":"2010","journal-title":"Microbes Infect"},{"key":"R15-20241101","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5402\/2012\/375806","article-title":"Comparison between fluconazole with oral protexin combination and fluconazole in the treatment of vulvovaginal candidiasis","volume":"1","author":"Nouraei","year":"2012","journal-title":"ISRN Obstet Gynecol"},{"key":"R16-20241101","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.ejogrb.2012.12.031","article-title":"Efficacy of orally applied probiotic capsules for bacterial vaginosis and other vaginal infections: A double-blind, randomized, placebo-controlled study","volume":"168","author":"Vujic","year":"2013","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"R17-20241101","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1186\/s12879-015-0971-3","article-title":"Vaginal colonisation by probiotic lactobacilli and clinical outcome in women conventionally treated for bacterial vaginosis and yeast infection","volume":"15","author":"Pendharkar","year":"2015","journal-title":"BMC Infect Dis"},{"key":"R18-20241101","first-page":"155","article-title":"Vaginal capsules of lactobacillus plantarum p17630 for prevention of relapse of candida vulvovaginitis: An Italian multicentre observational study","volume":"2","author":"Carriero","year":"2007","journal-title":"Int J Probiotics Prebiotics"}],"container-title":["Indian Journal of 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