{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:26:04Z","timestamp":1787772364127,"version":"build-2784847793"},"reference-count":9,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>Previous studies have shown that erythema nodosum-like lesions in patients with Beh\u00e7et's disease show cutaneous vasculitis of either phlebitis or dermal venulitis. To analyse the clinicopathological characteristics of superficial thrombophlebitis as well as cutaneous venulitis in Beh\u00e7et's disease. We re-evaluated the histopathological features of superficial thrombophlebitis in patients with Beh\u00e7et's disease. Five patients, one man and four women, developed superficial thrombophlebitis on the lower extremities. Two of the patients had vascular Beh\u00e7et's disease, both also developed deep vein thrombosis. One patient had intestinal Beh\u00e7et's disease. In all cases, venulitis in the overlying lower dermis or adjacent subcutis spreading from the main affected subcutaneous thrombophlebitis lesions was observed. Both neutrophilic venulitis (n = 2) and lymphocytic venulitis (n = 3) were observed at the same depth level or upper\/lower location of the thrombophlebitis in the same specimens. In addition, concurrent venulitis with fibrin thrombus and fibrinoid necrosis was observed in one case, suggesting that fibrin thrombus affected both venules and muscular veins. By contrast, arteritis or arteriolitis at the same depth level was not observed. Our results showed histopathological features of coexistent thrombophlebitis and venulitis without involvement of either arteries or arterioles in the biopsied specimens of superficial thrombophlebitis. Further studies are necessary to support that those unique histopathological findings are the characteristic features and significant diagnostic indicators of Beh\u00e7et's disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijd.ijd_229_22","type":"journal-article","created":{"date-parts":[[2024,5,29]],"date-time":"2024-05-29T12:15:14Z","timestamp":1716984914000},"page":"721-724","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Coexistence of Superficial Thrombophlebitis and Cutaneous Venulitis in Beh\u00e7et's Disease"],"prefix":"10.4103","volume":"67","author":[{"given":"Mayu","family":"Sato","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ko-Ron","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiyuki","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-16-20240829","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1002\/art.40375","article-title":"Nomenclature of cutaneous vasculitis: dermatologic addendum to the 2012 revised international Chapel Hill consensus conference nomenclature of vasculitides","volume":"70","author":"Sunderk\u00f6tter","year":"2018","journal-title":"Arthritis Rheumatol"},{"key":"R2-16-20240829","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1034\/j.1600-0560.2003.00033.x","article-title":"Cutaneous vasculitis: A review","volume":"30","author":"Crowson","year":"2003","journal-title":"J Cutan Pathol"},{"key":"R3-16-20240829","doi-asserted-by":"crossref","first-page":"71","DOI":"10.2165\/00128071-200809020-00001","article-title":"Clinical approach to cutaneous vasculitis","volume":"9","author":"Chen","year":"2008","journal-title":"Am J Clin Dermatol"},{"key":"R4-16-20240829","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1111\/1346-8138.13381","article-title":"Beh\u00e7et's disease: A comprehensive review with a focus on epidemiology, etiology and clinical features, and management of mucocutaneous lesions","volume":"43","author":"Alpsoy","year":"2016","journal-title":"J Dermatol"},{"key":"R5-16-20240829","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/S0190-9622(97)80318-0","article-title":"Cutaneous vasculitis in Beh\u00e7et's disease: A clinical and histopathologic study of 20 patients","volume":"36","author":"Chen","year":"1997","journal-title":"J Am Acad Dermatol"},{"key":"R6-16-20240829","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1097\/00000372-200010000-00001","article-title":"Histopathologic features of erythema nodosum-like lesions in Beh\u00e7et's disease: A comparison with erythema nodosum focusing on the role of vasculitis","volume":"22","author":"Kim","year":"2000","journal-title":"Am J Dermatopathol"},{"key":"R7-16-20240829","doi-asserted-by":"crossref","first-page":"681","DOI":"10.2340\/00015555-1349","article-title":"Erythema nodosum-like lesions in Beh\u00e7et's disease: A clinicopathological study of 26 cases","volume":"92","author":"Misago","year":"2012","journal-title":"Acta Derm Venereol"},{"key":"R8-16-20240829","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1111\/jdv.12107","article-title":"The international criteria for Beh\u00e7et's disease (ICBD): a collaborative study of 27 countries on the sensitivity and specificity of the new criteria","volume":"28","author":"Davatchi","year":"2014","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"R9-16-20240829","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1097\/DAD.0b013e3181d7759d","article-title":"The misdiagnosis of superficial thrombophlebitis as cutaneous polyarteritis nodosa: Features of the internal elastic lamina and the compact concentric muscular layer as diagnostic pitfalls","volume":"32","author":"Chen","year":"2010","journal-title":"Am J Dermatopathol"}],"container-title":["Indian Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ijd.ijd_229_22","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T18:41:22Z","timestamp":1787769682000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ijd.ijd_229_22"}},"subtitle":["Report of 5 Cases"],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":9,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.4103\/ijd.ijd_229_22","relation":{},"ISSN":["0019-5154"],"issn-type":[{"value":"0019-5154","type":"print"}],"subject":[],"published":{"date-parts":[[2022,11]]}}}