{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:30:37Z","timestamp":1787772637790,"version":"build-2784847793"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Recent years have witnessed a dramatic increase in chronic unresponsive dermatophytosis. A study was conducted to quantify the proportion of patients with chronic dermatophytosis and to determine the clinico-mycological predictors of chronicity including antifungal susceptibility.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Hospital-based cross-sectional study design was adopted. Four hundred and twenty-five patients were studied. The outcome variable was chronic dermatophytosis and the determinants were clinico-mycological characteristics. Chi-square and odds ratio (OR) with 95% confidence interval (CI) were calculated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Chronic dermatophytosis was seen in 29.4%. Past history of dermatophytosis, OR 0.44 (95% CI 0.28\u20130.68); family history of dermatophytosis, OR 1.66 (95% CI 1.06\u20132.56); HIV infection, OR 9.88 (95% CI 1.09\u201389.33); treatment with topical antifungals, OR 2.4 (95% CI 1.5\u20133.9); systemic antifungals, OR 3.9 (95% CI 2.5\u20136.1); topical steroids, OR 2.02 (95% CI 1.25\u20133.25); multiple-site infection, OR 1.97 (95% CI 1.24\u20133.13); and tinea unguium, OR 6.52 (95% CI 2.89\u201314.7) were the significant determinants.\n                      <jats:italic toggle=\"yes\">Trichophyton mentagrophytes<\/jats:italic>\n                      (73.6%) was the most common isolate followed by\n                      <jats:italic toggle=\"yes\">Trichophyton rubrum<\/jats:italic>\n                      and\n                      <jats:italic toggle=\"yes\">Microsporum gypseum<\/jats:italic>\n                      (13.2%) each. A percentage of 77.4 of the isolates were resistant\u201473.6% isolates to terbinafine and 3.8% isolates to fluconazole. None of the isolates were resistant to itraconazole.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Significant determinants were host-related factors. Thorough history taking, patient examination, and education can improve the present scenario. Microbiological resistance was not a significant predictor. High proportion of resistant strains should be an eye opener. Developing and adopting a standard uniform treatment protocol throughout the country should be the need of the hour.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijd.ijd_283_20","type":"journal-article","created":{"date-parts":[[2024,5,29]],"date-time":"2024-05-29T12:20:44Z","timestamp":1716985244000},"page":"329","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":4,"title":["Chronic 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