{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:39:18Z","timestamp":1787071158772,"version":"build-2736575974"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,5]]},"abstract":"\n Background:<\/jats:title>\n \n Genetic variations associated with nonprogression of HIV infection to AIDS are enriched in psoriasis patients.\n HCP5<\/jats:italic>\n gene 335 T > G and\n chemokine C receptor type 5 (CCR5)<\/jats:italic>\n gene \u039432 polymorphisms are associated with HIV nonprogression phenotype.\n <\/jats:p>\n <\/jats:sec>\n \n Aim:<\/jats:title>\n \n The aim of this study was to determine the association of\n HCP5<\/jats:italic>\n gene 335 T > G (rs2395029) and\n CCR5<\/jats:italic>\n gene \u039432 (rs333) polymorphisms with psoriasis vulgaris (PV).\n <\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n \n Genotype of\n HCP5<\/jats:italic>\n gene 335 T > G and CCR5 gene \u039432 polymorphisms were determined by polymerase chain reaction (PCR)-restriction fragment length polymorphism and allele-specific PCR methods, respectively.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n The frequency of\n HCP5<\/jats:italic>\n gene 335 T > G SNP was ~7 times higher in PV patients than in the control group (\n P<\/jats:italic>\n = 1.49 \u00d7 10\n \u20138<\/jats:sup>\n ; odds ratio [OR] = 10.2; 0.95 confidence interval [CI]: 3.9\u201326.8). OR for the occurrence of\n HCP5<\/jats:italic>\n 335 G allele in either homozygous or heterozygous genotype in PV patients was 13.1 (0.95 CI: 4.7\u201336.1). The strength of association was higher with moderate-to-severe subgroup (\n P<\/jats:italic>\n = 3.29 \u00d7 10\n \u20139<\/jats:sup>\n ; OR = 18.4; 0.95 CI: 6.2\u201354.9) than with mild subgroup (\n P<\/jats:italic>\n = 2.1 \u00d7 10\n \u20134<\/jats:sup>\n ; OR = 8.3; 0.95 CI: 2.6\u201323.3). In addition, the strength of association was higher with Type I (\n P<\/jats:italic>\n = 9.53 \u00d7 10\n \u20138<\/jats:sup>\n ; OR = 15.3; 0.95 CI: 5.1\u201346.5) than with Type II subgroup (\n P<\/jats:italic>\n = 6.8 \u00d7 10\n \u20136<\/jats:sup>\n ; OR = 11.0; 0.95 CI: 3.6\u201333.9). Type I gene \u039432 polymorphism was observed neither among psoriatic nor among healthy individuals.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n \n Our results indicate that\n HCP5<\/jats:italic>\n gene 335 T > G polymorphism and not CCR5 gene \u039432 polymorphism is associated with the increased risk of developing PV.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/ijd.ijd_285_18","type":"journal-article","created":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T05:11:28Z","timestamp":1559020288000},"page":"182-186","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":6,"title":["Evaluation of HCP5 and Chemokine C Receptor type 5 Gene Polymorphisms in Indian Psoriatic Patients"],"prefix":"10.4103","volume":"64","author":[{"given":"Deepa","family":"Rajesh","sequence":"first","affiliation":[{"name":"From the Department of Cell Biology and Molecular Genetics, Sri Devaraj Urs Academy of Higher Education and Research, Kolar, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudeep","family":"Nagraj","sequence":"additional","affiliation":[{"name":"From the Department of Cell Biology and Molecular Genetics, Sri Devaraj Urs Academy of Higher Education and Research, Kolar, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K S Praveen","family":"Kumar","sequence":"additional","affiliation":[{"name":"From the Department of Cell Biology and Molecular Genetics, Sri Devaraj Urs Academy of Higher Education and Research, Kolar, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A V Moideen","family":"Kutty","sequence":"additional","affiliation":[{"name":"From the Department of Cell Biology and Molecular Genetics, Sri Devaraj Urs Academy of Higher Education and Research, Kolar, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharath","family":"Balakrishna","sequence":"additional","affiliation":[{"name":"From the Department of Cell Biology and Molecular Genetics, Sri Devaraj Urs Academy of Higher Education and Research, Kolar, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20250921","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1111\/bjd.12375","article-title":"Heritability of psoriasis in a large twin sample","volume":"169","author":"L\u00f8nnberg","year":"2013","journal-title":"Br J Dermatol"},{"key":"R2-20250921","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1111\/j.1346-8138.2012.01504.x","article-title":"Current understanding of human genetics and genetic analysis of psoriasis","volume":"39","author":"Oka","year":"2012","journal-title":"J 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