{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:35:39Z","timestamp":1787841339601,"version":"build-2784847793"},"reference-count":35,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Melatonin is a hormone that regulates the sleep\u2013wake cycle and has immunomodulatory and anti-inflammatory roles.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims:<\/jats:title>\n                    <jats:p>The aim of this study is to assess melatonin levels and investigate the association with pruritus severity, sleep quality, and depressive symptoms in dermatoses with nocturnal pruritus.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>The study was a prospective study with 82 participants, including 41 patients and 41 healthy volunteers. The visual analog scale (VAS), Pittsburg Sleep Quality Index (PSQI), and Beck Depression Inventory (BDI) were recorded for each patient. To assess the melatonin levels, urinary 6-sulfatoxymelatonin levels in the first urine in the morning were measured.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Melatonin concentrations were significantly lower (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.007), while the BDI (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.001) and PSQI (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.001) scores were significantly higher in the patients with pruritus than in the healthy control subjects. There was an inverse correlation between melatonin levels and PSQI scores (r = \u22120.355,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.023), and a positive correlation was detected between BDI scores and PSQI scores (r = 0.631,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.001) in the pruritus group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Melatonin levels were found to decrease in relation to sleep quality in nocturnal pruritus patients. Low melatonin levels in these patients may be associated with sleep disorders and pruritus.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijd.ijd_31_21","type":"journal-article","created":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T03:01:56Z","timestamp":1649818916000},"page":"609-615","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":10,"title":["The Association between Melatonin Levels and Sleep Quality in Patients with Pruritus: A Potential Biomarker on a Candidate Future Treatment"],"prefix":"10.4103","volume":"66","author":[{"given":"Yasemin","family":"Erdem","sequence":"first","affiliation":[{"name":"From the Department of Dermatology, Health Science University, Sisli Hamidiye Etfal Training and Research Hospital, istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0130lknur K\u0131van\u00e7","family":"Altunay","sequence":"additional","affiliation":[{"name":"From the Department of Dermatology, Health Science University, Sisli Hamidiye Etfal Training and Research Hospital, istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ezgi","family":"\u00d6zkur","sequence":"additional","affiliation":[{"name":"From the Department of Dermatology, Health Science University, Sisli Hamidiye Etfal Training and Research Hospital, istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fcl","family":"\u015eekerlisoy","sequence":"additional","affiliation":[{"name":"From the Department of Dermatology, Health Science University, Sisli Hamidiye Etfal Training and Research Hospital, istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ezgi Akta\u015f","family":"Karabay","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology, Bah\u00e7e\u015fehir University Faculty of Medicine, istanbul, 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