{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T17:24:34Z","timestamp":1787765074543,"version":"build-2784847793"},"reference-count":22,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,11]]},"abstract":"Abstract<\/jats:title>\n \n Background:<\/jats:title>\n Mycosis fungoides (MF) is the most common cutaneous T-cell lymphoma with unknown etiopathogenesis. Oxidant and antioxidant balance is important for cell function and normal metabolism. An imbalance between pro-oxidants and antioxidants causes oxidative stress. A recent focus has been on thiol\/disulphide homeostasis as a novel marker of oxidative stress.<\/jats:p>\n <\/jats:sec>\n \n Aims and Objectives:<\/jats:title>\n This study aimed to evaluate the role of oxidative stress in MF by analysing thiol\/disulphide homeostasis.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n A total of 103 patients (48 female, 55 male) and a control group of 120 healthy individuals (48 female, 72 male) from two tertiary care hospitals were included in our study. Serum native thiol, total thiol and disulphide levels were evaluated using novel method developed by Erel and Neeliolu.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Native thiol levels were 340.30 \u00b1 87.44 in the patient group and 401.62 \u00b1 69.45 in the control group. Total thiol value was 374.17 \u00b1 87.78 in the patient group and 428.54 \u00b1 70.05 in the control group. Native thiol and total thiol levels were significantly lower in the patient group compared to the control group (\n P<\/jats:italic>\n < 0.001 and\n P<\/jats:italic>\n < 0.001). The disulphide value was 16.93 \u00b1 6.46 in the patient group and 13.46 \u00b1 5.06 in the control group. Disulphide levels were found to be significantly higher in the patient group compared to the control group (\n P<\/jats:italic>\n < 0.001).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n In our study, thiol\/disulphide balance shifted towards disulphide which indicates the presence of oxidative stress especially in the early stage while 93.2% of our patients had early-stage MF. We think that this may have pathogenetic and prognostic significance.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/ijd.ijd_339_23","type":"journal-article","created":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T05:05:37Z","timestamp":1704776737000},"page":"724-724","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of Oxidative Stress by Thiol\/Disulphide Homeostasis in Patients with Mycosis Fungoides: A Prospective Double-Centre Study"],"prefix":"10.4103","volume":"68","author":[{"given":"Funda","family":"Erduran","sequence":"first","affiliation":[{"name":"From the Department of Dermatology, Ankara City Hospital, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esra","family":"Ad\u0131\u015fen","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Gazi University Faculty of Medicine, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmet","family":"Soyug\u00fcr","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Gazi University Faculty of Medicine, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Funda","family":"Eren","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, Ankara City Hospital, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salim","family":"Ne\u015felio\u011flu","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, Faculty of Medicine, Ankara Y\u0131ld\u0131r\u0131m Beyaz\u0131t University, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d6zcan","family":"Erel","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, Faculty of Medicine, Ankara Y\u0131ld\u0131r\u0131m Beyaz\u0131t University, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,1,9]]},"reference":[{"key":"R1-20240829","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1182\/blood-2018-11-881268","article-title":"The 2018 update of the WHO-EORTC classification for primary cutaneous lymphomas","volume":"133","author":"Willemze","year":"2019","journal-title":"Blood"},{"key":"R2-20240829","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.2105\/AJPH.89.8.1240","article-title":"Twenty-year trends in the reported incidence of mycosis fungoides and associated mortality","volume":"89","author":"Weinstock","year":"1999","journal-title":"Am J Public Health"},{"key":"R3-20240829","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1590\/S0365-05962012000600001","article-title":"Mycosis fungoides and S\u00e9zary syndrome: Clinical, histopathological and immunohistochemical review and update","volume":"87","author":"Yamashita","year":"2012","journal-title":"An Bras Dermatol"},{"key":"R4-20240829","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.3390\/jcm11061507","article-title":"Thiol-disulfide homeostasis in skin diseases","volume":"11","author":"Georgescu","year":"2022","journal-title":"J Clin Med"},{"key":"R5-20240829","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.3906\/sag-2003-64","article-title":"Thiol-disulfide homeostasis: An integrated approach with biochemical and clinical aspects","volume":"50","author":"Erel","year":"2020","journal-title":"Turk J Med Sci"},{"key":"R6-20240829","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.4103\/jcrt.JCRT_553_17","article-title":"Thiol-disulfide homeostasis in breast cancer patients","volume":"15","author":"Eryilmaz","year":"2019","journal-title":"J Cancer Res Ther"},{"key":"R7-20240829","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.clinbiochem.2014.09.026","article-title":"A novel and automated assay for thiol\/disulphide homeostasis","volume":"47","author":"Erel","year":"2014","journal-title":"Clin Biochem"},{"key":"R8-20240829","doi-asserted-by":"crossref","first-page":"205.e1","DOI":"10.1016\/j.jaad.2013.07.049","article-title":"Primary cutaneous T-cell lymphoma (mycosis fungoides and S\u00e9zary syndrome): Part I. 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