{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:26:17Z","timestamp":1787772377004,"version":"build-2784847793"},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>\n                      Atopic dermatitis is a common inflammatory skin condition with an underlying pathophysiology that may have impact beyond the skin. Previous studies showed a higher prevalence of dental cavities in patients with atopic dermatitis. Our study aimed to establish an association of other dental anomalies in patients with moderate\u2013severe atopic dermatitis. We prospectively recruited 15 patients with moderate\u2013severe atopic dermatitis for a formal dental examination by a paediatric dentist. Hypodontia and microdontia were more prevalent in patients with moderate\u2013severe atopic dermatitis as compared to reference populations and were statistically significant. Dental caries, enamel hypoplasia and agenesis of 3\n                      <jats:sup>rd<\/jats:sup>\n                      molars were also prevalent but did not reach statistical significance. Our study shows a novel finding of higher prevalence of dental anomalies in patients with moderate\u2013severe atopic dermatitis which may warrant further investigation due to its clinical implications.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijd.ijd_375_22","type":"journal-article","created":{"date-parts":[[2024,5,29]],"date-time":"2024-05-29T12:14:59Z","timestamp":1716984899000},"page":"539-542","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":5,"title":["Association of Moderate\u2013Severe Atopic Dermatitis with Dental Anomalies"],"prefix":"10.4103","volume":"67","author":[{"given":"Sean Y.","family":"Tan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean W.","family":"M. Leong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chin-ying S.","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nisha S.","family":"Chandran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-10-20240829","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/S0140-6736(20)31286-1","article-title":"Atopic dermatitis","volume":"396","author":"Langan","year":"2020","journal-title":"Lancet"},{"key":"R2-10-20240829","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1111\/bjd.15587","article-title":"Prevalence and descriptive epidemiology of atopic dermatitis and its impact on quality of life in Singapore","volume":"178","author":"Cheok","year":"2018","journal-title":"Br J Dermatol"},{"key":"R3-10-20240829","doi-asserted-by":"crossref","first-page":"2000","DOI":"10.1016\/j.jaci.2016.10.038","article-title":"Atopic dermatitis and early childhood caries: Results of the GUSTO study","volume":"139","author":"Kalhan","year":"2017","journal-title":"J Allergy Clin Immunol"},{"key":"R4-10-20240829","first-page":"122","article-title":"Atopic dermatitis and dental manifestations","volume":"152","author":"Perugia","year":"2017","journal-title":"G Ital Dermatol Venereol"},{"key":"R5-10-20240829","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1111\/j.1600-0528.2004.00158.x","article-title":"A meta-analysis of the prevalence of dental agenesis of permanent teeth","volume":"32","author":"Polder","year":"2004","journal-title":"Community Dent Oral Epidemiol"},{"key":"R6-10-20240829","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1111\/jerd.12302","article-title":"Prevalence of dental developmental anomalies of permanent teeth in children and their influence on esthetics","volume":"29","author":"Fekonja","year":"2017","journal-title":"J Esthet Restor Dent"},{"key":"R7-10-20240829","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/bdj.2007.732","article-title":"Familial human hypodontia\u2014is it all in the genes?","volume":"203","author":"Cobourne","year":"2007","journal-title":"Br Dent J"},{"key":"R8-10-20240829","first-page":"96","article-title":"Molecular genetic of atopic dermatitis: An update","volume":"10","author":"Al-Shobaili","year":"2016","journal-title":"Int J Health Sci (Qassim"},{"key":"R9-10-20240829","doi-asserted-by":"crossref","first-page":"3153","DOI":"10.1172\/JCI125170","article-title":"Sonic Hedgehog signaling limits atopic dermatitis via Gli2-driven immune regulation","volume":"129","author":"Papaioannou","year":"2019","journal-title":"J Clin Invest"},{"key":"R10-10-20240829","doi-asserted-by":"crossref","first-page":"E1587","DOI":"10.3390\/ijms21051587","article-title":"Sonic Hedgehog signaling and tooth development","volume":"21","author":"Hosoya","year":"2020","journal-title":"Int J Mol Sci"}],"container-title":["Indian Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ijd.ijd_375_22","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T18:41:31Z","timestamp":1787769691000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ijd.ijd_375_22"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9]]},"references-count":10,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.4103\/ijd.ijd_375_22","relation":{},"ISSN":["0019-5154"],"issn-type":[{"value":"0019-5154","type":"print"}],"subject":[],"published":{"date-parts":[[2022,9]]}}}