{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:26:52Z","timestamp":1787772412948,"version":"build-2784847793"},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>Oral melanoacanthoma is an uncommon reactive lesion, characterized by basal and prickle cell keratinocyte proliferation surrounded by pigment-laden dendritic melanocytes. Plasma cell cheilitis (PCC) is an inflammatory disorder of unknown aetiology, microscopically presenting a dense plasma cell infiltrate. Most PCC cases affect the lower lip. Langerhans cell hyperplasia (LCHyp), a non-neoplastic counterpart of the LC proliferations, has been reported in association with chronic inflammatory skin diseases. Here, we present an unusual association of melanoacanthoma, PCC and LCHyp on the lower lip in a 59-old-year male, expanding the clinicopathological spectrum of these uncommon lesions. The dendritic melanocytes were highlighted by Fontana\u2013Masson stain and HMB-45, whereas S100, CD1a and CD207 evidenced numerous LCs. MUM1\/IRF4, EMA, and CD138 highlighted sheets of polyclonal plasma cells, with an IgG4+\/IgG+ ratio of 24%. FTA-ABS test for syphilis was negative.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijd.ijd_380_22","type":"journal-article","created":{"date-parts":[[2024,5,29]],"date-time":"2024-05-29T12:13:57Z","timestamp":1716984837000},"page":"404-408","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Melanoacanthoma, Plasma Cell Cheilitis and Langerhans Cell Hyperplasia on the Lower Lip"],"prefix":"10.4103","volume":"67","author":[{"given":"Ev\u00e2nio V.","family":"Silva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heitor A.","family":"Silveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo M.","family":"Nogueira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana C.","family":"Campos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anderson T.","family":"F. da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge E.","family":"Le\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-15-20240829","doi-asserted-by":"crossref","first-page":"119","DOI":"10.4103\/2229-5178.110638","article-title":"Melanoacanthoma: Uncommon presentation of an uncommon condition","volume":"4","author":"Vasani","year":"2013","journal-title":"Indian Dermatol Online J"},{"key":"R2-15-20240829","first-page":"e374","article-title":"Oral melanoacanthoma and oral melanotic macule: A report of 8 cases, review of the literature, and immunohistochemical analysis","volume":"12","author":"Carlos-Bregni","year":"2007","journal-title":"Med Oral Patol Oral Cir Bucal"},{"key":"R3-15-20240829","doi-asserted-by":"crossref","first-page":"e2018075","DOI":"10.4322\/acr.2018.075","article-title":"Plasma cell cheilitis: The diagnosis of a disorder mimicking lip cancer","volume":"9","author":"Dos Santos","year":"2019","journal-title":"Autops Case Rep"},{"key":"R4-15-20240829","doi-asserted-by":"crossref","first-page":"536","DOI":"10.5021\/ad.2017.29.5.536","article-title":"Plasma cell cheilitis: A clinicopathological and immunohistochemical study of 13 cases","volume":"29","author":"Lee","year":"2017","journal-title":"Ann Dermatol"},{"key":"R5-15-20240829","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1111\/j.1600-0560.2006.00659.x","article-title":"Lymphomatoid papulosis with CD1a+ dendritic cell hyperplasia, mimicking Langerhans cell histiocytosis","volume":"34","author":"Jokinen","year":"2007","journal-title":"J Cutan Pathol"},{"key":"R6-15-20240829","doi-asserted-by":"crossref","first-page":"e12950","DOI":"10.1111\/sji.12950","article-title":"Immunohistochemical characterization of immune cell infiltration in paediatric and adult Langerhans cell histiocytosis","volume":"92","author":"Paredes","year":"2020","journal-title":"Scand J Immunol"},{"key":"R8-15-20240829","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1111\/j.1468-3083.2004.00791.x","article-title":"Plasma cell cheilitis","volume":"18","author":"Rocha","year":"2004","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"R9-15-20240829","doi-asserted-by":"crossref","first-page":"506","DOI":"10.2340\/00015555-2909","article-title":"Evaluation of IgG4+plasma cell infiltration in patients with systemic plasmacytosis and other plasma cell-infiltrating skin diseases","volume":"98","author":"Takeoka","year":"2018","journal-title":"Acta Derm Venereol"},{"key":"R10-15-20240829","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1111\/iej.13464","article-title":"IgG4-positive plasma cells are more often detected in chronic periapical lesions arising from permanent rather than primary teeth","volume":"54","author":"Polanco","year":"2021","journal-title":"Int Endod J"},{"key":"R11-15-20240829","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.anndiagpath.2015.01.003","article-title":"Oral syphilis: Report of three cases and characterization of the inflammatory cells","volume":"19","author":"Strieder","year":"2015","journal-title":"Ann Diagn Pathol"}],"container-title":["Indian Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ijd.ijd_380_22","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T18:45:22Z","timestamp":1787769922000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ijd.ijd_380_22"}},"subtitle":["An Unusual Association and Immunohistochemical Analysis"],"short-title":[],"issued":{"date-parts":[[2022,7]]},"references-count":10,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.4103\/ijd.ijd_380_22","relation":{},"ISSN":["0019-5154"],"issn-type":[{"value":"0019-5154","type":"print"}],"subject":[],"published":{"date-parts":[[2022,7]]}}}