{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T17:24:42Z","timestamp":1787765082466,"version":"build-2784847793"},"reference-count":51,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>\n                      Atopic dermatitis is a chronic inflammatory skin condition common in early childhood. Acute exacerbation is frequently associated with\n                      <jats:italic toggle=\"yes\">Staphylococcus aureus<\/jats:italic>\n                      colonization.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims and Objectives:<\/jats:title>\n                    <jats:p>\n                      This study aims to explore the relationship between\n                      <jats:italic toggle=\"yes\">S. aureus<\/jats:italic>\n                      skin and nasal colonization with pediatric atopic dermatitis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      A systematic review and meta-analysis were conducted by comparing atopic dermatitis patients aged \u226418 years and nondiseased controls. A random-effects model was used to obtain the pooled prevalence and odds ratio of\n                      <jats:italic toggle=\"yes\">S. aureus<\/jats:italic>\n                      colonization at eczematous skin, nonlesional skin, and nasal cavity. Subgroup analyses for colonization with methicillin-resistant\n                      <jats:italic toggle=\"yes\">S. aureus<\/jats:italic>\n                      were also evaluated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      A total of 2,670 cases and 1,224 controls from 26 studies were included in the meta-analysis.\n                      <jats:italic toggle=\"yes\">S. aureus<\/jats:italic>\n                      colonization at eczematous skin and nasal cavity is significantly higher in atopic dermatitis compared to control with odds ratios of 10.55 (95% confidence interval [CI]; 4.85-22.92,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .001) and 2.38 (nasal cavity; 95% CI; 1.46-3.90,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .001), respectively. The pooled prevalence of skin and nasal colonization were 55.0% (eczematous skin; 95% CI; 38.3-71.7), 23.3% (nonlesional skin; 95% CI; 12.6-33.9), and 56.3% (95% CI; 43.2-69.4), respectively. Methicillin-resistant\n                      <jats:italic toggle=\"yes\">S. aureus<\/jats:italic>\n                      strain was obtained from the nares and eczematous skin with rates of 11.6% (95% CI; 6.5-16.7) and 8.5% (95% CI; 4.3-12.8), respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>\n                      Children with atopic dermatitis are more prone to skin and nasal colonization by\n                      <jats:italic toggle=\"yes\">S. aureus<\/jats:italic>\n                      compared to nondiseased individuals.\n                    <\/jats:p>\n                  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