{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:30:40Z","timestamp":1787772640890,"version":"build-2784847793"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,3]]},"abstract":"\n Background:<\/jats:title>\n \n Vitiligo is an autoimmune disorder involving inflammatory damage to melanocytes.\n STAT3<\/jats:italic>\n genetic variant (rs744166 T > C) increases inflammatory signaling via JAK\/STAT pathway.\n <\/jats:p>\n <\/jats:sec>\n \n Aim:<\/jats:title>\n \n The purpose of this study was to check whether this translates into an association between vitiligo and\n STAT3<\/jats:italic>\n gene variant (rs744166 T > C).\n <\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n \n This is a case-control study. A total of 56 vitiligo patients and 90 healthy, age and gender-matched volunteers were recruited for the study. The\n STAT3<\/jats:italic>\n gene variant (rs744166 T > C) was genotyped using the restriction fragment length polymorphism method.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n The frequency of the minor allele \u2018C\u2019 was higher in vitiligo patients (72.3%) than in healthy volunteers (57.8%). The difference between the two groups was statistically significant (\n P<\/jats:italic>\n = 0.006; OR = 1.9 with 95% CI). The genotypic variant showed the highest association with vitiligo in the dominant model (\n P<\/jats:italic>\n = 0.001).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n \n This study shows that the\n STAT3<\/jats:italic>\n gene variant (rs744166 T > C) is associated with vitiligo. This observation underlines the importance of the JAK\/STAT signaling pathway in vitiligo pathogenesis.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/ijd.ijd_515_21","type":"journal-article","created":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T17:19:24Z","timestamp":1724951964000},"page":"133-137","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Novel Association between STAT3 Gene Variant and Vitiligo"],"prefix":"10.4103","volume":"67","author":[{"given":"Vaibhav","family":"Venkatesh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deena C.","family":"Mendez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T 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