{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:27:20Z","timestamp":1787772440031,"version":"build-2784847793"},"reference-count":34,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>\n                      The association of Vitamin D (vit.D) and Interleukin 17 (IL-17) with acne vulgaris is uncertain in spite of induction of IL-17 by\n                      <jats:italic toggle=\"yes\">Propionibacterium acnes (P. acnes)<\/jats:italic>\n                      and the role of vit.D in various inflammatory skin disorders including acne. The objectives of present study were to evaluate the levels of serum 25-hydroxyvitamin D3 [25(OH)D] and IL-17 in acne patients and age- and sex-matched controls and to compare them with the severity of acne as measured by Global Acne Grading System (GAGS).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>The study included 50 patients of acne and 30 healthy controls. Serum 25(OH) D and IL-17 levels were measured using chemiluminescence immunoassay (CLIA) and enzyme-linked immunosorbent assay (ELISA), respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Vitamin D deficiency was detected in 28% of patients with acne but only in 6.7% of the healthy controls (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      value 0.022). The levels of 25(OH)D were inversely associated with the severity of acne (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001). The mean serum IL-17 levels were significantly raised (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001) in acne patients (8.215 \u00b1 5.33 pg\/mL) as compared to controls (2.486 \u00b1 2.12 pg\/mL). A significant rise in levels of IL-17 was observed with the severity of acne (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001). Further, a highly significant negative correlation (Correlation Coefficient: -0.668) was noted between serum IL-17 and 25(OH) D levels along with disease severity in acne patients (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      value &lt; 0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Raised IL-17 levels in acne correlate negatively with vit.D deficiency and both are significantly more prevalent in patients with acne as compared to healthy controls.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijd.ijd_551_19","type":"journal-article","created":{"date-parts":[[2024,5,29]],"date-time":"2024-05-29T12:20:44Z","timestamp":1716985244000},"page":"291-296","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":8,"title":["Correlation of Serum 25-Hydroxy Vitamin D and Interleukin-17 Levels with Disease Severity in Acne Vulgaris"],"prefix":"10.4103","volume":"66","author":[{"given":"Ajeet","family":"Singh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ananta","family":"Khurana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kabir","family":"Sardana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niharika","family":"Dixit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anubhuti","family":"Chitkara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-10-20240829","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1177\/146642409111100205","article-title":"Acne","volume":"111","author":"Leung","year":"1991","journal-title":"J R Soc Health"},{"key":"R2-10-20240829","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1186\/1476-511X-9-141","article-title":"Clinical implications of lipid peroxidation in acne vulgaris: Old wine in new bottles","volume":"9","author":"Bowe","year":"2010","journal-title":"Lipids Health Dis"},{"key":"R3-10-20240829","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1111\/j.1346-8138.2001.tb00105.x","article-title":"The role of the antioxidative defense system in papulo pustular acne","volume":"28","author":"Basak","year":"2001","journal-title":"J Dermatol"},{"key":"R4-10-20240829","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1126\/science.1123933","article-title":"Toll-like receptor triggering of a vit.D-mediated human antimicrobial response","volume":"311","author":"Liu","year":"2006","journal-title":"Science"},{"key":"R5-10-20240829","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1046\/j.1523-1747.2003.12550_6.x","article-title":"Propionibacterium acnes-reactive T helper-1 cells in the skin of patients with acne vulgaris","volume":"121","author":"Mouser","year":"2003","journal-title":"J Invest Dermatol"},{"key":"R6-10-20240829","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1016\/S0002-9440(10)62479-0","article-title":"Inflammation and extracellular matrix degradation mediated by activated transcription factors nuclear factor-kappaB and activator protein-1 in inflammatory acne lesions in vivo","volume":"166","author":"Kang","year":"2005","journal-title":"Am J Pathol"},{"key":"R7-10-20240829","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.1111\/jocd.12934","article-title":"Serum interleukin-17 as a novel biomarker in patients with acne vulgaris","volume":"18","author":"Ebrahim","year":"2019","journal-title":"J Cosmet Dermatol"},{"key":"R8-10-20240829","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1038\/jid.2013.334","article-title":"Propionibacterium acnes induces an IL-17 response in acne vulgaris that is regulated by vitamin A and vitamin D","volume":"134","author":"Agak","year":"2014","journal-title":"J Invest Dermatol"},{"key":"R9-10-20240829","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1038\/jid.2014.290","article-title":"Propionibacterium acnes promotes Th17 and Th17\/Th1 responses in acne patients","volume":"135","author":"Kistowska","year":"2015","journal-title":"J Invest Dermatol"},{"key":"R10-10-20240829","doi-asserted-by":"crossref","first-page":"e105238","DOI":"10.1371\/journal.pone.0105238","article-title":"IL-17\/Th17 pathway is activated in acne lesions","volume":"9","author":"Kelh\u00e4l\u00e4","year":"2014","journal-title":"PLoS One"},{"key":"R11-10-20240829","doi-asserted-by":"crossref","first-page":"3653","DOI":"10.1128\/MCB.05020-11","article-title":"1,25-Dihydroxyvitamin D(3) ameliorates Th17 autoimmunity via transcriptional modulation of interleukin-17A","volume":"31","author":"Joshi","year":"2011","journal-title":"Mol Cell Biol"},{"key":"R12-10-20240829","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1111\/jocd.12715","article-title":"Lesional and circulating levels of interleukin-17 and 25-hydroxycholecalciferol in active acne vulgaris: Correlation to disease severity","volume":"18","author":"Abd-Elmaged","year":"2019","journal-title":"J Cosmet Dermatol"},{"key":"R13-10-20240829","first-page":"68","article-title":"Assessment of the role of vitamin D and interleukin-17 in the pathogenesis of acne vulgaris","volume":"53","author":"Topan","year":"2019","journal-title":"Turkderm-Turk Arch Dermatol Venereology"},{"key":"R14-10-20240829","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1046\/j.1365-4362.1997.00099.x","article-title":"A comparison of current acne grading systems and proposal of a novel system","volume":"36","author":"Doshi","year":"1997","journal-title":"Int J Dermatol"},{"key":"R15-10-20240829","doi-asserted-by":"crossref","first-page":"321","DOI":"10.11613\/BM.2013.039","article-title":"Effect of sample type, centrifugation and storage conditions on vitamin D concentration","volume":"23","author":"Colak","year":"2013","journal-title":"Biochem Med (Zagreb"},{"key":"R16-10-20240829","doi-asserted-by":"crossref","first-page":"4175","DOI":"10.4049\/jimmunol.1002535","article-title":"The tachykinins substance P and hemokinin-1 favor the generation of human memory Th17 cells by inducing IL-1\u03b2, IL-23, and TNF-like 1A expression by monocytes","volume":"186","author":"Cunin","year":"2011","journal-title":"J Immunol"},{"key":"R17-10-20240829","first-page":"39","article-title":"Evaluation of serum leaking enzymes and investigation into new biomarkers for exercise-induced muscle damage","volume":"20","author":"Kanda","year":"2014","journal-title":"Exerc Immunol Rev"},{"key":"R18-10-20240829","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.jsbmb.2008.10.010","article-title":"Characterization of the vitamin D endocrine system in human sebocytes in vitro","volume":"113","author":"Kr\u00e4mer","year":"2009","journal-title":"J Steroid Biochem Mol Biol"},{"key":"R19-10-20240829","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1111\/1523-1747.ep12343866","article-title":"Stimulation versus inhibition of keratinocytes growth by 1,25-dihydroxy vitamin D3:Dependence on cell culture conditions","volume":"106","author":"Gniadecki","year":"1996","journal-title":"J Invest Dermatol"},{"key":"R20-10-20240829","doi-asserted-by":"crossref","first-page":"327","DOI":"10.4103\/0019-5154.113959","article-title":"Expression of inflammatory biomarkers from cultured sebocytes was influenced by treatment with vitamin D","volume":"58","author":"Lee","year":"2013","journal-title":"Indian J Dermatol"},{"key":"R21-10-20240829","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1007\/s00109-010-0590-9","article-title":"Vitamin D and molecular actions on the immune system: Modulation of innate and autoimmunity","volume":"88","author":"Kamen","year":"2010","journal-title":"J Mol Med (Berl"},{"key":"R22-10-20240829","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1055\/s-2007-958715","article-title":"Vitamins as hormones","volume":"39","author":"Reichrath","year":"2007","journal-title":"Horm Metab Res"},{"key":"R23-10-20240829","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1111\/j.1365-2133.2006.07486.x","article-title":"Comedolytic effect of topically applied active vitamin D3 analogue on pseudocomedones in the rhino mouse","volume":"155","author":"Hayashi","year":"2006","journal-title":"Br J Dermatol"},{"key":"R24-10-20240829","doi-asserted-by":"crossref","first-page":"e0161162","DOI":"10.1371\/journal.pone.0161162","article-title":"Comparison of vitamin D levels in patients with and without acne: A case-control study combined with a randomized controlled trial","volume":"11","author":"Lim","year":"2016","journal-title":"PLoS One"},{"key":"R25-10-20240829","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1111\/jocd.12503","article-title":"Vitamin D levels in acne vulgaris patients treated with oral isotretinoin","volume":"18","author":"El-Hamd","year":"2019","journal-title":"J Cosmet Dermatol"},{"key":"R26-10-20240829","first-page":"238","article-title":"Serum 25-hydroxy vitamin D levels in patients with acne vulgaris and its association with disease severity","volume":"12","author":"Toossi","year":"2015","journal-title":"Clin Cases Miner Bone Metab"},{"key":"R27-10-20240829","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.3390\/nu10101525","article-title":"Plasma 25-hydroxy vitamin D is not associated with acne vulgaris","volume":"10","author":"Al-Taiar","year":"2018","journal-title":"Nutrients"},{"key":"R28-10-20240829","doi-asserted-by":"crossref","first-page":"52","DOI":"10.25002\/tji.2018.761","article-title":"Levels of IL-12, IL-17, and LL-37 in Acne Vulgaris","volume":"6","author":"Murlistyarini","year":"2018","journal-title":"Turk J Immunol"},{"key":"R29-10-20240829","doi-asserted-by":"crossref","first-page":"160","DOI":"10.15395\/mkb.v48n3.846","article-title":"Comparison of interleukin-17 serum level between papulopustular and comedonal types of acne vulgaris","volume":"48","author":"Maulinda","year":"2018","journal-title":"Majalah Kedokteran Bandun"},{"key":"R30-10-20240829","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.jid.2017.07.842","article-title":"Phenotype and antimicrobial activity of Th17 cells induced by Propionibacterium acnes strains associated with healthy and acne skin","volume":"138","author":"Agak","year":"2017","journal-title":"J Investig Dermatol"},{"key":"R31-10-20240829","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1111\/bjd.15879","article-title":"Sebocytes contribute to skin inflammation by promoting the differentiation of T helper 17 cells","volume":"178","author":"Mattii","year":"2018","journal-title":"Br J Dermatol"},{"key":"R32-10-20240829","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1159\/000479925","article-title":"Is There a relation between vitamin D and interleukin-17 in vitiligo. A cross-sectional study?","volume":"233","author":"Aly","year":"2017","journal-title":"Dermatology"},{"key":"R33-10-20240829","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1016\/j.jaad.2013.07.026","article-title":"Assessment of interleukin-17 and vitamin D serum levels in psoriatic patients","volume":"69","author":"El-Moaty Zaher","year":"2013","journal-title":"J Am Acad Dermatol"},{"key":"R34-10-20240829","doi-asserted-by":"crossref","first-page":"392","DOI":"10.4103\/ijd.IJD_483_16","article-title":"Propionibacterium acnes and the Th1\/Th17 Axis, Implications in Acne Pathogenesis and Treatment","volume":"62","author":"Sardana","year":"2017","journal-title":"Indian J Dermatol"}],"container-title":["Indian Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ijd.IJD_551_19","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T18:46:37Z","timestamp":1787769997000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ijd.IJD_551_19"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5]]},"references-count":34,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.4103\/ijd.ijd_551_19","relation":{},"ISSN":["0019-5154"],"issn-type":[{"value":"0019-5154","type":"print"}],"subject":[],"published":{"date-parts":[[2021,5]]}}}