{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T17:24:34Z","timestamp":1787765074572,"version":"build-2784847793"},"reference-count":17,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,11]]},"abstract":"Abstract<\/jats:title>\n \n Background:<\/jats:title>\n Palmoplantar keratoderma (PPK) is a heterogeneous group of hereditary or acquired disorders characterised by excessive epidermal thickening of the palms and soles. Proper knowledge about the aetiology of the disease and clinico-demographic profile helps in planning management and predicting outcomes.<\/jats:p>\n <\/jats:sec>\n \n Aims and Objective:<\/jats:title>\n To determine the prevalence of different dermatoses and describe their clinico-histological correlation in acquired palmoplantar keratoderma.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n \n An institution-based cross-sectional study conducted after obtaining Ethics-Committee permission and consent from participants. Patients of any age or gender presenting with acquired PPK were recruited. The calculated sample size was 67 by using the\n prevalence rate (p)<\/jats:italic>\n of 22.2%,\n allowable error (L)<\/jats:italic>\n of 10%, the confidence level of 95% (\n z<\/jats:italic>\n =\n 1.96<\/jats:italic>\n ), and an infinite population size of 20,000. Patients were evaluated by taking demographic and clinical data in a pre-designed case record form, necessary laboratory investigations and histopathological examination that wereevaluated by three blinded experts. The pooled data were analysed with statistical software.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n Among the 67 participants, Psoriasis was diagnosed clinically in 39 (58.2%) and histologically in 7 (10.4%), Lichen planus (LP) clinically in 16 (23.9%) and histologically in 9 (13.4%), Pityriasis rubra pilaris (PRP) in 8 (11.9%) patients clinically and 7 (10.4%) histologically and Hyperkeratotic eczema (HKE) in 4 (6%) clinically and 43 (64.2%) histopathologically. There was very poor inter-rater agreement (Kappa = 0.148, SE 0.0047, 95% CI 0.057 to 0.24). The clinico-pathological correlation was found to be agreeable in 17.9% Psoriasis, 56.2% LP and 87.5% PRP. HKE was commonly misdiagnosed as Psoriasis in 65.1% of patients.<\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n Hyperkeratotic lesions of the palm and sole often present with overlapping clinical features and a skin biopsy has to be done to aid in diagnosis.<\/jats:p>\n <\/jats:sec>\n \n Limitation:<\/jats:title>\n Stratification of the clinical expertise of clinicians was done during the analysis.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/ijd.ijd_572_23","type":"journal-article","created":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T05:06:41Z","timestamp":1704776801000},"page":"603-610","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["An Institution Based Cross-Sectional Observational Aetiological Study Correlating the Clinico-Pathological Findings in Patients Presenting with Acquired Palmoplantar Keratoderma"],"prefix":"10.4103","volume":"68","author":[{"given":"Indrayudh","family":"Sen","sequence":"first","affiliation":[{"name":"From the Department of Dermatology, Bankura Sammilani Medical College, Bankura, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhiman","family":"Tarafdar","sequence":"additional","affiliation":[{"name":"From the Department of Dermatology, Bankura Sammilani Medical College, Bankura, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Somenath","family":"Sarkar","sequence":"additional","affiliation":[{"name":"From the Department of Dermatology, Bankura Sammilani Medical College, Bankura, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudipta","family":"Roy","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Deben Mahata Government Medical College and Hospital, Purulia, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nilay K.","family":"Das","sequence":"additional","affiliation":[{"name":"Department of Dermatology, College of Medicine and Sagore Datta Hospital, Kolkata, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madhusudan","family":"Pal","sequence":"additional","affiliation":[{"name":"From the Department of Dermatology, Bankura Sammilani Medical College, Bankura, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaguftah","family":"Nasreen","sequence":"additional","affiliation":[{"name":"From the Department of Dermatology, Bankura Sammilani Medical College, Bankura, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anirban","family":"Mukherjee","sequence":"additional","affiliation":[{"name":"From the Department of Dermatology, Bankura Sammilani Medical College, Bankura, 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