{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:24:01Z","timestamp":1787772241578,"version":"build-2784847793"},"reference-count":44,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:p>\n                    The study of antimicrobial-resistant\n                    <jats:italic toggle=\"yes\">Propionibacterium acnes<\/jats:italic>\n                    was not conducted regularly, especially in Indonesia. Conversely, regular monitoring of antibiotic efficacy through\n                    <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                    testing to assess the evolution of current resistance patterns is obligated; thus, filling the gap caused by a lack of appropriate antibiotic surveillance is required. Analyse the correlation between resistance patterns of\n                    <jats:italic toggle=\"yes\">P. acnes<\/jats:italic>\n                    to doxycycline, clindamycin, erythromycin and azithromycin with the severity of acne vulgaris. This is an analytic observational laboratory study with a cross-sectional design of mild to severe acne vulgaris (AV) patients. Specimens were obtained from comedones of 71 patients, which were cultured and identified using biochemical examination. Antimicrobial resistance (doxycycline, clindamycin, erythromycin and azithromycin) to\n                    <jats:italic toggle=\"yes\">P. acnes<\/jats:italic>\n                    was tested by disc diffusion method. Among 71 samples collected, 40 (56.3%)\n                    <jats:italic toggle=\"yes\">P. acnes<\/jats:italic>\n                    isolates were cultured and identified. The incidence of\n                    <jats:italic toggle=\"yes\">P. acnes<\/jats:italic>\n                    resistance to more than one antimicrobial was 45%. Antimicrobial resistances were clindamycin 42.5%, erythromycin 40%, azithromycin 23.5% and doxycycline 12.5%, respectively. According to the contingency coefficient test, there was moderate correlation between the resistance pattern of\n                    <jats:italic toggle=\"yes\">P. acnes<\/jats:italic>\n                    to clindamycin (\n                    <jats:italic toggle=\"yes\">r<\/jats:italic>\n                    = 0.485,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = &lt;0.001) and doxycycline (\n                    <jats:italic toggle=\"yes\">r<\/jats:italic>\n                    = 0.433,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = 0.002) and AV severity. There was weak correlation between the resistance pattern of\n                    <jats:italic toggle=\"yes\">P. acnes<\/jats:italic>\n                    to erythromycin (\n                    <jats:italic toggle=\"yes\">r<\/jats:italic>\n                    = 0.333;\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = 0.025) and azithromycin (\n                    <jats:italic toggle=\"yes\">r<\/jats:italic>\n                    = 0.321;\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = 0.032) and AV severity. In conclusion, there is a correlation between the pattern of P. acnes resistance to doxycycline, clindamycin, erythromycin, azithromycin and severity of AV.\n                  <\/jats:p>","DOI":"10.4103\/ijd.ijd_623_22","type":"journal-article","created":{"date-parts":[[2024,5,15]],"date-time":"2024-05-15T02:26:16Z","timestamp":1715739976000},"page":"488-494","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Correlation between Antimicrobial Resistant Propionibacterium Acnes and Severity of Acne Vulgaris: Findings from a Tertiary Hospital"],"prefix":"10.4103","volume":"68","author":[{"given":"Maria Mayfinna","family":"Gozali","sequence":"first","affiliation":[{"name":"From the Department of Dermatology and Venereology, Sriwijaya University, Palembang, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuli","family":"Kurniawati","sequence":"additional","affiliation":[{"name":"From the Department of Dermatology and Venereology, Sriwijaya University, Palembang, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mutia","family":"Devi","sequence":"additional","affiliation":[{"name":"From the Department of Dermatology and Venereology, Sriwijaya University, Palembang, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erial","family":"Bahar","sequence":"additional","affiliation":[{"name":"From the Department of Anatomy, Faculty of Medicine, Sriwijaya University, Palembang, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Dewi","sequence":"additional","affiliation":[{"name":"From the Department of Microbiology, Health Laboratory Center for Palembang, Palembang, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulia Farida","family":"Yahya","sequence":"additional","affiliation":[{"name":"From the Department of Dermatology and Venereology, Sriwijaya University, Palembang, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Rusmawardiana","sequence":"additional","affiliation":[{"name":"From the Department of Dermatology and Venereology, Sriwijaya University, Palembang, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah Diba","family":"Zulkarnain","sequence":"additional","affiliation":[{"name":"From the Department of Dermatology and Venereology, Sriwijaya University, Palembang, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soenarto","family":"Kartowigno","sequence":"additional","affiliation":[{"name":"From the Department of Dermatology and Venereology, Sriwijaya University, Palembang, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20240829","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.clindermatol.2017.09.006","article-title":"Acne vulgaris: The metabolic syndrome of the pilosebaceous 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