{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T17:20:19Z","timestamp":1791566419901,"version":"4.3.4"},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Context:<\/jats:title>\n                    <jats:p>Isotretinoin is commonly prescribed for the treatment of acne. However, its association with inflammatory bowel disease (IBD) could not be confirmed due to inconsistencies in the literature. Furthermore, no related study has been conducted on an Asian population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims:<\/jats:title>\n                    <jats:p>The aim of this study was to investigate the association between isotretinoin and inflammatory bowel disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Material:<\/jats:title>\n                    <jats:p>A nationwide, population-based, case-control study using the National Health Insurance Service database of South Korea was conducted. The case group comprised 107,434 patients with IBD, while the control group comprised 393,830 patients who were matched using a 1:4 propensity score. Data on isotretinoin exposure within the previous 5 years were extracted, and a multivariable-adjusted, conditional, logistic, regression analysis was performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>After adjusting for age, sex, underlying disease, the Charlson co-morbidity index, and tetracycline use, a significant association between isotretinoin exposure and IBD was found, with an odds ratio of 1.20 (95% confidence interval, 1.10\u20131.30). Furthermore, the association appeared to become stronger with longer exposure, more of a cumulative dose, and a longer time since the first exposure. When analyzed separately for ulcerative colitis and Crohn\u2019s disease, isotretinoin exposure was significantly associated with both diseases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Our study reveals a dose\u2013response relationship between isotretinoin exposure and IBD risk in an Asian population. Healthcare professionals should be aware of the association and consider alternative medications for acne treatment, particularly in patients who are at a higher risk of developing IBD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijd.ijd_644_23","type":"journal-article","created":{"date-parts":[[2024,8,20]],"date-time":"2024-08-20T04:01:20Z","timestamp":1724126480000},"page":"301-305","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Association between Isotretinoin Exposure and Inflammatory Bowel Disease: A Nationwide Case-Control Study in South Korea"],"prefix":"10.4103","volume":"69","author":[{"given":"Jin H.","family":"Hyeong","sequence":"first","affiliation":[{"name":"From the Department of Dermatology, Hallym University Sacred Heart Hospital, Anyang, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minkook","family":"Son","sequence":"additional","affiliation":[{"name":"Department of Physiology, Dong-A University College of Medicine, Busan, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dayeon","family":"Jeong","sequence":"additional","affiliation":[{"name":"From the Department of Dermatology, Hallym University Sacred Heart Hospital, Anyang, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye J.","family":"Jang","sequence":"additional","affiliation":[{"name":"From the Department of Dermatology, Hallym University Sacred Heart Hospital, Anyang, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwang H.","family":"Kim","sequence":"additional","affiliation":[{"name":"From the Department of Dermatology, Hallym University Sacred Heart Hospital, Anyang, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwang J.","family":"Kim","sequence":"additional","affiliation":[{"name":"From the Department of Dermatology, Hallym University Sacred Heart Hospital, Anyang, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun J.","family":"Park","sequence":"additional","affiliation":[{"name":"From the Department of Dermatology, Hallym University Sacred Heart Hospital, Anyang, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,8,19]]},"reference":[{"key":"R1-20240829","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1111\/ijd.15089","article-title":"Isotretinoin in the management of acne vulgaris:Practical prescribing","volume":"60","author":"Fallah","year":"2021","journal-title":"Int J Dermatol"},{"key":"R2-20240829","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1097\/MEG.0000000000000496","article-title":"Does exposure to isotretinoin increase the risk for the development of inflammatory bowel disease? A meta-analysis","volume":"28","author":"Lee","year":"2016","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"R3-20240829","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.jaad.2020.07.042","article-title":"Risk of new-onset inflammatory bowel disease among patients with acne vulgaris exposed to isotretinoin","volume":"84","author":"Wright","year":"2021","journal-title":"J Am Acad Dermatol"},{"key":"R4-20240829","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1016\/j.jaad.2022.12.015","article-title":"Isotretinoin and the risk of inflammatory bowel disease and irritable bowel syndrome- A large-scale global study","volume":"88","author":"Kridin","year":"2023","journal-title":"J Am Acad Dermatol"},{"key":"R5-20240829","doi-asserted-by":"crossref","first-page":"2769","DOI":"10.1016\/S0140-6736(17)32448-0","article-title":"Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: A systematic review of population-based studies","volume":"390","author":"Ng","year":"2017","journal-title":"Lancet"},{"key":"R6-20240829","doi-asserted-by":"crossref","first-page":"2610","DOI":"10.1038\/ajg.2010.303","article-title":"Potential association between the oral tetracycline class of antimicrobials used to treat acne and inflammatory bowel disease","volume":"105","author":"Margolis","year":"2010","journal-title":"Am J Gastroenterol"},{"key":"R7-20240829","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1345\/aph.10368","article-title":"Isotretinoin-induced inflammatory bowel disease in an adolescent","volume":"35","author":"Reniers","year":"2001","journal-title":"Ann Pharmacother"},{"key":"R8-20240829","doi-asserted-by":"crossref","first-page":"142","DOI":"10.4240\/wjgs.v6.i7.142","article-title":"Isotretinoin and ulcerative colitis:A case report and review of the literature","volume":"6","author":"Papaconstantinou","year":"2014","journal-title":"World J Gastrointest Surg"},{"key":"R9-20240829","first-page":"52","article-title":"Isotretinoin-induced inflammatory bowel disease","volume":"64","author":"Passier","year":"2006","journal-title":"Neth J Med"},{"key":"R10-20240829","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1016\/j.suc.2015.07.006","article-title":"Inflammatory bowel disease: Historical perspective, epidemiology, and risk factors","volume":"95","author":"Malik","year":"2015","journal-title":"Surg Clin North Am"}],"container-title":["Indian Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ijd.ijd_644_23","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:02:02Z","timestamp":1787839322000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ijd.ijd_644_23"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":10,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.4103\/ijd.ijd_644_23","relation":{},"ISSN":["0019-5154","1998-3611"],"issn-type":[{"value":"0019-5154","type":"print"},{"value":"1998-3611","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7]]},"assertion":[{"value":"2023-06-01","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-01","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}