{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:27:06Z","timestamp":1787772426946,"version":"build-2784847793"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The use of alternative treatment methods, particularly medicinal herbs from the family Compositae, significantly contributes to the increase in the incidence of allergic contact dermatitis among patients with chronic venous insufficiency.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>Estimating frequency of contact sensitization among patients with chronic venous insufficiency and determining the most common contact sensitizers from the series of bio-origin allergens from the Compositae family and ubiquitous weeds of Vojvodina.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>The total number of 266 patients with suspected contact dermatitis was divided into two groups: the experimental group consisted of patients with chronic venous insufficiency (EG), and the control group consisted of patients without chronic venous insufficiency (CG). All subjects were tested with allergens of biological origin from the family Compositae, screening allergen SL-mix and original extracts of ubiquitous weed plants of Vojvodina.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Patch test revealed a positive reaction to allergens of the Compositae family in 6.69% in the experimental group, and in 4.17% in the control group. The standardized response rate to the SL-mix in the experimental group was 2.07%, while in the control group, it was 1.51%. The presence of a positive reaction to at least one extract of ubiquitous weed plants of Vojvodina was determined in 6.11% in the experimental group, and in 3.23% of patients in the control group. No statistically significant difference in response rates was found between the examined groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Establishing the diagnosis of Compositae dermatitis can be supplemented by additional testing with weed plant extracts from a specific geographical area, resulting in the detection of novel unknown allergens.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijd.ijd_705_21","type":"journal-article","created":{"date-parts":[[2024,5,29]],"date-time":"2024-05-29T12:14:59Z","timestamp":1716984899000},"page":"625","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Contact Sensitization to Allergens of Biological Origin from the Compositae Family and Original Extracts of Ubiquitous Weed Plants of Vojvodina among Patients with Chronic Venous Insufficiency"],"prefix":"10.4103","volume":"67","author":[{"given":"Vujanovi\u0107","family":"Ljuba","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakovljevi\u0107","family":"Sanja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Golu\u0161in","family":"Zoran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Levakov","family":"Olivera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-45-20240829","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1001\/archderm.140.10.1241","article-title":"Contact sensitivity in patients with leg ulcerations: A North American study","volume":"140","author":"Saap","year":"2004","journal-title":"Arch Dermatol"},{"key":"R2-45-20240829","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1111\/j.1600-0536.2007.01253.x","article-title":"Contact sensitivity in patients with venous leg ulcers in Serbia: Comparison with contact dermatitis patients and relationship to ulcer duration","volume":"58","author":"Janki\u0107evi\u0107","year":"2008","journal-title":"Contact Dermatitis"},{"key":"R5-45-20240829","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1111\/j.1365-4632.2005.02317.x","article-title":"Direct triggers for ulceration in patients with venous insufficiency","volume":"44","author":"Shai","year":"2005","journal-title":"Int J Dermatol"},{"key":"R6-45-20240829","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1111\/j.0105-1873.2006.00777.x","article-title":"Contact allergy in patients with chronic venous leg ulcers\u2014Possible role of chronic venous insufficiency","volume":"54","author":"Zmudzinska","year":"2006","journal-title":"Contact Dermatitis"},{"key":"R8-45-20240829","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1111\/j.0105-1873.2006.00709.x","article-title":"Contact allergy to herbal teas derived from Asteraceae plants","volume":"54","author":"Lundh","year":"2006","journal-title":"Contact Dermatitis"},{"key":"R9-45-20240829","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1111\/j.1600-0536.2007.00987.x","article-title":"Contact sensitization in patients with chronic venous leg ulcers in Singapore","volume":"56","author":"Lim","year":"2007","journal-title":"Contact Dermatitis"},{"key":"R10-45-20240829","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1002\/pds.4064","article-title":"Contact allergy to ingredients of topical medications: Results of the European Surveillance System on Contact Allergies (ESSCA), 2009\u20132012","volume":"25","author":"Uter","year":"2016","journal-title":"Pharmacoepidemiol Drug Saf"},{"key":"R12-45-20240829","first-page":"101","article-title":"Results of the clinical examination of an ointment with marigold (Calendula officinalis) extract in the treatment of venous leg ulcers","volume":"27","author":"Duran","year":"2005","journal-title":"Int J Tissue React"},{"key":"R13-45-20240829","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1111\/cod.12939","article-title":"Allergic contact dermatitis caused by topical herbal remedies: Importance of patch testing with the patients\u2019 own products","volume":"78","author":"Gilissen","year":"2018","journal-title":"Contact Dermatitis"},{"key":"R14-45-20240829","doi-asserted-by":"crossref","first-page":"43","DOI":"10.2298\/MPNS0302043J","article-title":"Compositae dermatitis [Compositae dermatitis]","volume":"56","author":"Jovanovi\u0107","year":"2003","journal-title":"Med Pregl"},{"key":"R15-45-20240829","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1111\/j.0105-1873.2004.00413.x","article-title":"Sesquiterpene lactone mix patch testing supplemented with dandelion extract in patients with allergic contact dermatitis, atopic dermatitis and non-allergic chronic inflammatory skin diseases","volume":"51","author":"Jovanovi\u0107","year":"2004","journal-title":"Contact Dermatitis"},{"key":"R16-45-20240829","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1111\/cod.12916","article-title":"Clinical patterns of Compositae dermatitis in Danish monosensitized patients","volume":"78","author":"Paulsen","year":"2018","journal-title":"Contact Dermatitis"},{"key":"R17-45-20240829","doi-asserted-by":"crossref","first-page":"6290","DOI":"10.1007\/s11356-019-04146-w","article-title":"Asteraceae species as potential environmental factors of allergy","volume":"26","author":"Denisow-Pietrzyk","year":"2019","journal-title":"Environ Sci Pollut Res"},{"key":"R18-45-20240829","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1111\/cod.13346","article-title":"Screening for Compositae contact sensitization with sesquiterpene lactones and Compositae mi\u00d72.5% pet","volume":"81","author":"Paulsen","year":"2019","journal-title":"Contact Dermatitis"},{"key":"R19-45-20240829","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1111\/cod.13169","article-title":"Contact sensitization to plants of the Compositae family: Data of the Information Network of Departments of Dermatology (IVDK) from 2007 to 2016","volume":"80","author":"Bauer","year":"2019","journal-title":"Contact Dermatitis"},{"key":"R20-45-20240829","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1111\/cod.12918","article-title":"A proposal to create an extension to the European baseline series","volume":"78","author":"Wilkinson","year":"2018","journal-title":"Contact Dermatitis"},{"key":"R21-45-20240829","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1111\/j.1600-0536.1990.tb01590.x","article-title":"Patch testing with the \u201csesquiterpene lactone mix\u201d: A marker for contact allergy to Compositae and other sesquiterpene-lactone-containing plants. A multicentre study of the EECDRG","volume":"22","author":"Ducombs","year":"1990","journal-title":"Contact Dermatitis"},{"key":"R22-45-20240829","doi-asserted-by":"crossref","first-page":"807","DOI":"10.3797\/scipharm.1306-17","article-title":"Quantification of sesquiterpene lactones in asteraceae plant extracts: Evaluation of their allergenic potential","volume":"81","author":"Salapovic","year":"2013","journal-title":"Sci Pharm"},{"key":"R23-45-20240829","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1111\/j.1600-0536.1999.tb06062.x","article-title":"Compositae mix is a more sensitive test for Compositae dermatitis than the sesquiterpene lactone mix","volume":"40","author":"Von der Werth","year":"1999","journal-title":"Contact Dermatitis"},{"key":"R24-45-20240829","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1111\/j.1600-0536.1993.tb04528.x","article-title":"Compositae dermatitis in a Danish dermatology department in one year (I). Results of routine patch testing with the sesquiterpene lactone mix supplemented with aimed patch testing with extracts and sesquiterpene lactones of Compositae plants","volume":"29","author":"Paulsen","year":"1993","journal-title":"Contact Dermatitis"},{"key":"R25-45-20240829","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1111\/j.1600-0536.1998.tb05680.x","article-title":"Occupational dermatitis in Danish gardeners and greenhouse workers (III). Compositae-related symptoms","volume":"38","author":"Paulsen","year":"1998","journal-title":"Contact Dermatitis"},{"key":"R26-45-20240829","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1046\/j.1365-2133.1998.02270.x","article-title":"Patch testing for Compositae allergy","volume":"138","author":"Goulden","year":"1998","journal-title":"Br J Dermatol"},{"key":"R27-45-20240829","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1111\/j.1600-0536.1994.tb01954.x","article-title":"Sesquiterpene lactone mix is not an adequate screen for Compositae allergy","volume":"31","author":"Green","year":"1994","journal-title":"Contact Dermatitis"},{"key":"R28-45-20240829","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1111\/j.1600-0536.1999.tb05994.x","article-title":"Routine patch testing with the sesquiterpene lactone mix in Europe: A 2-year experience. A multicentre study of the EECDRG","volume":"40","author":"Paulsen","year":"1999","journal-title":"Contact Dermatitis"},{"key":"R29-45-20240829","first-page":"18","article-title":"Patch test sensitization to Compositae mix, sesquiterpene-lactone mix, Compositae extracts, laurel leaf, Chlorophorin, Mansonone A, and dimethoxydalbergione","volume":"12","author":"Kanerva","year":"2001","journal-title":"Am J Contact Dermat"},{"key":"R30-45-20240829","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1111\/j.1600-0536.1999.tb06063.x","article-title":"Patch test sensitization after use of the Compositae mix","volume":"40","author":"Wilkinson","year":"1999","journal-title":"Contact Dermatitis"},{"key":"R31-45-20240829","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1046\/j.1440-0960.1999.00341.x","article-title":"Compositae dermatitis","volume":"40","author":"Gordon","year":"1999","journal-title":"Australas J Dermatol"},{"key":"R32-45-20240829","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1034\/j.1600-0536.2002.460507.x","article-title":"Parthenium dermatitis presenting as photosensitive lichenoid eruption. A new clinical variant","volume":"46","author":"Verma","year":"2002","journal-title":"Contact Dermatitis"}],"container-title":["Indian Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ijd.ijd_705_21","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T18:46:00Z","timestamp":1787769960000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ijd.ijd_705_21"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9]]},"references-count":28,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.4103\/ijd.ijd_705_21","relation":{},"ISSN":["0019-5154"],"issn-type":[{"value":"0019-5154","type":"print"}],"subject":[],"published":{"date-parts":[[2022,9]]}}}