{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:23:57Z","timestamp":1787772237804,"version":"build-2784847793"},"reference-count":19,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>\n                      Syphilis is a treatable bacterial infection caused by\n                      <jats:italic toggle=\"yes\">Treponema pallidum<\/jats:italic>\n                      . There has been a change in incidence of syphilis in various nations over the years.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>To study the epidemiological trends, demographic profile, high-risk behaviour, clinical pattern, and stage of syphilis over the last ten years in patients presenting to an STD clinic in a tertiary care hospital.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods:<\/jats:title>\n                    <jats:p>This was a retrospective observational study over ten years. Records of all confirmed syphilis cases were analysed in relation to demography and clinical profile.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>There were a total of 3,110 STD patients among whom 31 cases (accounting for 0.99%) of confirmed syphilis were seen. There was a significant increase in cases in the last five years of study, especially in the last year. An increase in primary (PS) and secondary syphilis (SS) was observed. Males outnumbered females (3:1). Mean age of patients was 35.0 \u00b1 11.53 years. Professionals were most common (22.6%) having syphilis followed by farmers (19.35%). A significant proportion (45.1%) of our patients were at least graduates. Unprotected sex was seen in all the patients followed by extramarital\/premarital sex (71.35%). There were 16.12% of cases who had a history of paid sex and 9.7% were homosexuals. SS and latent syphilis were more common (38.7% each) than PS (19.35%). In PS single chancre and in SS truncal asymptomatic rash was the commonest clinical presentation. Limitation: Single-centre study, including only self-reported patients leading to a small sample size, is the major limitation of the study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The increased trend of primary and secondary syphilis in recent years highlights that there is a risk of an impending epidemic.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijd.ijd_788_22","type":"journal-article","created":{"date-parts":[[2024,5,15]],"date-time":"2024-05-15T01:44:33Z","timestamp":1715737473000},"page":"15-24","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":11,"title":["The Changing Trend of Syphilis"],"prefix":"10.4103","volume":"68","author":[{"given":"Mudita","family":"Gupta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghanshyam K.","family":"Verma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajni","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manish","family":"Sankhyan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renu","family":"Rattan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajeet Kumar","family":"Negi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-3-20240829","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1007\/s40471-018-0138-z","article-title":"An update on the global epidemiology of syphilis","volume":"5","author":"Kojima","year":"2018","journal-title":"Curr Epidemiol Rep"},{"key":"R2-3-20240829","doi-asserted-by":"crossref","first-page":"e0159309","DOI":"10.1371\/journal.pone.0159309","article-title":"Syphilis trends among men who have sex with men in the United States and Western Europe: A systematic review of trend studies published between 2004 and 2015","volume":"11","author":"Abara","year":"2016","journal-title":"PloS One"},{"key":"R3-3-20240829","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1177\/0956462416638224","article-title":"Syphilis incidence among men who have sex with men in China: Results from a meta-analysis","volume":"28","author":"Chen","year":"2017","journal-title":"Int J STD AIDS"},{"key":"R6-3-20240829","doi-asserted-by":"crossref","first-page":"102","DOI":"10.4103\/0253-7184.102117","article-title":"Evaluation of the usefulness of Treponema pallidum hemagglutination test in the diagnosis of syphilis in weak reactive Venereal Disease Research Laboratory sera","volume":"33","author":"Bala","year":"2012","journal-title":"Indian J Sex Transm Dis"},{"key":"R8-3-20240829","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1007\/s11904-021-00564-z","article-title":"The Intersection of HIV and syphilis: Update on the key considerations in testing and management","volume":"18","author":"Ren","year":"2021","journal-title":"Curr HIV\/AIDS Rep"},{"key":"R10-3-20240829","doi-asserted-by":"crossref","first-page":"149","DOI":"10.4103\/0253-7184.167151","article-title":"Changing trends in acquired syphilis at a tertiary care center of North India","volume":"36","author":"Nishal","year":"2015","journal-title":"Indian J Sex Transm Dis AIDS"},{"key":"R11-3-20240829","doi-asserted-by":"crossref","first-page":"161","DOI":"10.4103\/0378-6323.129403","article-title":"Syphilis among sexually transmitted infections clinic Attendees in a tertiary care institution. 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