{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T19:51:04Z","timestamp":1788292264197,"version":"build-2803163510"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Cutaneous adnexal tumors (CATs) are a large group of neoplasms of the skin and the pathological diagnosis can be challenging.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>The aim of this study was to examine clinicopathological features of malignant cutaneous adnexal tumors (MCATs) and to identify therapeutic and prognostic implications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>Twenty-six patients diagnosed with MCATs and operated in our center were included. Demographic and clinical characteristics of patients, tumor size, histological subtype, perineural and lymphovascular invasion, re-excision status, lymph node metastasis, distant metastasis, recurrence, follow-up, and treatment choice were recorded. All lesions were excised with 1 to 2-cm surgical margin. Surgical margin was determined according to tumor size.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Of 26 patients, 14 were males and 12 were females (median age: 66 years). Median follow-up was 52.08 months. Tumor location was the face in 69.2% (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 18) patients, followed by scalp and neck region. Four patients had coexisting skin tumors. Majority of MCATs (69.2%,\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 18) originated from sweat glands. Median tumor diameter was 4 (range, 0.8 to 17) cm. There was a statistically significant correlation between presence of perineural invasion and advanced disease (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.036). Majority of the patients had Stage 1-2 disease, while two patients had Stage 4 disease. In six patients (23.1%), re-excision was performed due to surgical margin positivity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Incidence of MCATs has an increasing trend with advanced age and these tumors are more commonly seen in men and in visible sites of the body such as head and neck and scalp. Wide resection according to tumor size is the first-line treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijd.ijd_838_21","type":"journal-article","created":{"date-parts":[[2024,5,15]],"date-time":"2024-05-15T01:44:33Z","timestamp":1715737473000},"page":"120","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Rare Tumors of Skin"],"prefix":"10.4103","volume":"68","author":[{"given":"Melekber \u00c7.","family":"\u00d6zkan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caner","family":"Kaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0130lker","family":"\u00c7i\u00e7ek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeynep D.A.","family":"Do\u011fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nihal D.","family":"Kocaaslan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00fclent","family":"Sa\u00e7ak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeliha L.","family":"Cinel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R2-28-20240829","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1001\/archdermatol.2010.105","article-title":"Cutaneous appendageal carcinoma incidence and survival patterns in the United States: A population-based study","volume":"146","author":"Blake","year":"2010","journal-title":"Arch Dermatol"},{"key":"R3-28-20240829","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1002\/jso.23346","article-title":"Survival after resection of cutaneous adnexal carcinomas with eccrine differentiation: Risk factors and trends in outcomes","volume":"108","author":"Avraham","year":"2013","journal-title":"J Surg Oncol"},{"key":"R4-28-20240829","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1001\/archdermatol.2011.229","article-title":"Rare tumors through the looking glass: An examination of malignant cutaneous adnexal tumors","volume":"147","author":"Martinez","year":"2011","journal-title":"Arch Dermatol"},{"key":"R5-28-20240829","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1007\/s002669900272","article-title":"Malignant tumors associated with nevus sebaceous: Therapeutic consequences","volume":"23","author":"Beer","year":"1999","journal-title":"Aesthetic Plast Surg"},{"key":"R6-28-20240829","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1111\/j.1346-8138.2008.00550.x","article-title":"Ten cases of sebaceous carcinoma arising in nevus sebaceus","volume":"35","author":"Izumi","year":"2008","journal-title":"J Dermatol"},{"key":"R7-28-20240829","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1097\/PAS.0b013e3181966762","article-title":"Morphologic diversity of malignant neoplasms arising in preexisting spiradenoma, cylindroma, and spiradenocylindroma based on the study of 24 cases, sporadic or occurring in the setting of Brooke-Spiegler syndrome","volume":"33","author":"Kazakov","year":"2009","journal-title":"Am J Surg Pathol"},{"key":"R8-28-20240829","doi-asserted-by":"crossref","first-page":"3372","DOI":"10.1002\/cncr.23963","article-title":"Incidence of cutaneous sebaceous carcinoma and risk of associated neoplasms: Insight into Muir-Torre syndrome","volume":"113","author":"Dores","year":"2008","journal-title":"Cancer"},{"key":"R9-28-20240829","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1097\/DAD.0b013e3181db1da3","article-title":"Cutaneous type adnexal tumors outside the skin","volume":"33","author":"Kazakov","year":"2011","journal-title":"Am J Dermatopathol"},{"key":"R11-28-20240829","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.det.2018.05.007","article-title":"Dermoscopy of adnexal tumors","volume":"36","author":"Zaballos","year":"2018","journal-title":"Dermatol Clin"},{"key":"R12-28-20240829","doi-asserted-by":"crossref","first-page":"832","DOI":"10.5858\/arpa.2018-0189-RA","article-title":"Skin adnexal tumors in plain language: A practical approach for the general surgical pathologist","volume":"143","author":"Fulton","year":"2019","journal-title":"Arch Pathol Lab Med"},{"key":"R13-28-20240829","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1002\/jso.23331","article-title":"Increasing incidence and survival of a rare skin cancer in the Netherlands. 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