{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:27:16Z","timestamp":1787772436576,"version":"build-2784847793"},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To describe clinical patterns, identify associated drugs, and perform causality assessment of cutaneous adverse drug reactions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>In this prospective, observational study, patients with signs of cutaneous drug reaction from the department of dermatology of a tertiary teaching hospital were included. Patients with viral exanthemas were excluded. The patterns of cutaneous drug reactions, and associated drugs were noted. Naranjo scale was used for causality assessment of adverse drug reactions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Sixty-five patients (mean age 38.1 years) were included. Skin lesions were seen after 2 days of drug consumption in 25 (38.5%) patients. Pigmentation, fixed drug eruption, and maculo-papular rashes were seen in 13 (20%), 22 (33.8%), and 12 (18.5%) patients, respectively. Thirty-five (53.85%) patients had other associated symptoms. Fever was seen in 22 (33.8%) patients. Thirty-two (49.2%) cases had exposure to antibacterial agents. Most commonly associated drugs with reactions were nonsteroidal anti-inflammatory agents 14 (21.5%) followed by beta-lactam antibiotics 12 (18.5%), and fluroquinolones 7 (10.8%). Fifty-seven (87.7%) adverse drugs reactions had \u201cprobable\u201d association with the drug.\u201d<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Fixed drug eruption is the commonest presentation of cutaneous adverse drug reactions and antimicrobial agents are most commonly associated with it. According to the Naranjo scale, the majority of the cutaneous drug reactions have a \u201cprobable\u201d association with the offending drugs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijd.ijd_874_20","type":"journal-article","created":{"date-parts":[[2024,5,29]],"date-time":"2024-05-29T12:21:23Z","timestamp":1716985283000},"page":"573","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Cutaneous Adverse Drug Reactions in a Tertiary Teaching Hospital"],"prefix":"10.4103","volume":"66","author":[{"given":"Anuja","family":"Jadhav","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharmila","family":"Patil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isheeta","family":"Manchanda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruchita","family":"Hasija","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anant","family":"Patil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-33-20240829","first-page":"52","article-title":"Retrospective analysis of adverse cutaneous drug reactions in patients hospitalized in Department of Dermatology and Venereology of Pomeranian Medical University in 1996-2006","volume":"54","author":"Kacalak-Rzepka","year":"2008","journal-title":"Ann Acad Med Stetin"},{"key":"R2-33-20240829","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1046\/j.1365-2125.2000.00132.x","article-title":"Epidemiology of drug exposure and adverse drug reactions in two swiss departments of internal medicine","volume":"49","author":"Fattinger","year":"2000","journal-title":"Br J Clin Pharmacol"},{"key":"R3-33-20240829","doi-asserted-by":"crossref","first-page":"795","DOI":"10.7326\/0003-4819-140-10-200405180-00009","article-title":"Clarifing adverse drug events: A clinician's guide to terminology, documenteion and reporting","volume":"140","author":"Nebeker","year":"2004","journal-title":"Ann Intern Med"},{"key":"R4-33-20240829","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1136\/bmj.329.7456.15","article-title":"Adverse drug reactions as cause of admission to hospital: Prospective analysis of 18,820 patients","volume":"329","author":"Pirmohamed","year":"2004","journal-title":"BMJ"},{"key":"R5-33-20240829","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1093\/ajhp\/60.3.253","article-title":"Evaluation of outpatient adverse drug reactions leading to hospitalization","volume":"60","author":"Wu","year":"2003","journal-title":"Ame J Health Syst Pharm"},{"key":"R6-33-20240829","doi-asserted-by":"crossref","first-page":"2","DOI":"10.4103\/0019-5154.39732","article-title":"Adverse cutaneous drug reaction","volume":"53","author":"Nayak","year":"2008","journal-title":"Indian J Dermatol"},{"key":"R7-33-20240829","first-page":"357","article-title":"Cutaneous drug reactions","volume":"53","author":"Svensson","year":"2001","journal-title":"Pharmacol Rev"},{"key":"R8-33-20240829","doi-asserted-by":"crossref","first-page":"518","DOI":"10.2340\/00015555-0143","article-title":"The prevalence of acute cutaneous drug reactions in a Scandinavian university hospital","volume":"86","author":"Borch","year":"2006","journal-title":"Acta Derm Venereol"},{"key":"R9-33-20240829","first-page":"95","article-title":"Cutaneous adverse drug reactions: Clinical pattern and causative agents - 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