{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:24:04Z","timestamp":1787772244946,"version":"build-2784847793"},"reference-count":6,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Role of oxidative stress in the pathogenesis of vitiligo.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>Estimation of serum and tissue catalase levels in morphological variants of vitiligo.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Settings and Design:<\/jats:title>\n                    <jats:p>A prospective case-control study was conducted in the outpatient department of Dermatology in Safdarjung hospital.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>We estimated levels of serum and tissue catalase in 30 vitiligo patients and 30 matched healthy controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Statistical Analysis:<\/jats:title>\n                    <jats:p>The data analysis was done in Statistical Package for Social Sciences (SPSS) version 21.0. Normality of data was tested by Kolmogorov\u2013Smirnov test.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Serum and tissue catalase was lower in vitiligo patients than controls. Serum catalase was lowest in vulgaris type, whereas in the acrofacial type had lowest tissue catalase levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Vitiligo patients have a generalized oxidative stress functioning at a higher pace as seen with decreased serum and tissue CAT which can well be taken as a marker of active disease and they can be helped with topical pseudoCAT preparations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijd.ijd_946_20","type":"journal-article","created":{"date-parts":[[2024,5,15]],"date-time":"2024-05-15T01:44:33Z","timestamp":1715737473000},"page":"120","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["A Case-Control Study of Serum and Tissue Catalase among Morphological Variants of Vitiligo"],"prefix":"10.4103","volume":"68","author":[{"given":"Nandhini","family":"Periasamy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V","family":"Ramesh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Matlani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-29-20240829","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1007\/s12291-010-0045-7","article-title":"Study of oxidative stress in vitiligo","volume":"26","author":"Jain","year":"2011","journal-title":"Indian J Clin Biochem"},{"key":"R2-29-20240829","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1111\/1523-1747.ep12371744","article-title":"Enzymic and non-enzymic antioxidants in epidermis and dermis of human skin","volume":"102","author":"Shindo","year":"1994","journal-title":"J Invest Dermatol"},{"key":"R3-29-20240829","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1159\/000246690","article-title":"Treatment of vitiligo with a topical application of pseudocatalase and calcium in combination with short term UVB exposure: A case study on 33 patients","volume":"190","author":"Schallreuter","year":"1995","journal-title":"Dermatol"},{"key":"R4-29-20240829","doi-asserted-by":"crossref","first-page":"186197","DOI":"10.1155\/2014\/186197","article-title":"Gender differences in clinicoepidemiological features of vitiligo: A cross-sectional analysis","volume":"2014","author":"Patil","year":"2014","journal-title":"ISRN Dermatol"},{"key":"R5-29-20240829","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1111\/j.1600-0781.2012.00648.x","article-title":"Evaluation of the effect of disease duration in generalized vitiligo on its clinical response to narrowband ultraviolet B phototherapy: Vitiligo, disease duration and response to NB-UVB","volume":"28","author":"Hallaji","year":"2012","journal-title":"Photodermatol Photoimmunol Photomed"},{"key":"R6-29-20240829","doi-asserted-by":"crossref","first-page":"268","DOI":"10.4103\/0378-6323.48427","article-title":"Determination of oxidative stress in vitiligo by measuring superoxide dismutase and catalase levels in vitiliginous and non-vitiliginous skin","volume":"75","author":"Sravani","year":"2009","journal-title":"Indian J Dermatol Venerol Leprol"}],"container-title":["Indian Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ijd.ijd_946_20","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T18:34:07Z","timestamp":1787769247000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ijd.ijd_946_20"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":6,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.4103\/ijd.ijd_946_20","relation":{},"ISSN":["0019-5154"],"issn-type":[{"value":"0019-5154","type":"print"}],"subject":[],"published":{"date-parts":[[2023,1]]}}}