{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:33:36Z","timestamp":1787762016422,"version":"build-2784847793"},"reference-count":19,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,1]]},"abstract":"\n Background and Objective:<\/jats:title>\n Menopause is a normal developmental stage in a woman's life marking the permanent cessation of menstruation. Calcium is predominant in intracellular signalling and its intracellular increase can affect the cell's proliferation, phagocytosis and cytokine secretion. IL-8 expression in various cells such as neutrophils and osteoblasts was reported to involve a calcium signalling pathway. Well-known functions of IL-8 includes help in angiogenesis, role in tumour progression, tissue remodelling, etc., Hence, the aim of this study was to establish the relationship between calcium-dependent IL-8 and periodontal disease in postmenopausal females.<\/jats:p>\n <\/jats:sec>\n \n Method:<\/jats:title>\n The study population included 52 postmenopausal women aged 45\u201357 years. The patients were divided into two groups in which group I included postmenopausal women without periodontitis and group II with periodontitis. Unstimulated salivary samples were collected from all the participants to evaluate IL-8 and calcium levels.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n There was a statistically significant difference in salivary IL-8 levels between the two groups (\n P<\/jats:italic>\n < 0.001), but there was no statistical difference in salivary calcium levels between the two groups (\n P<\/jats:italic>\n = 0.730). A weak negative correlation between salivary IL-8 and calcium was found in group I, while a weak positive correlation was found between the same in group II.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n Analysis of salivary IL-8 from the present study was in accordance with several previous studies. It can be concluded that saliva can also be used as a reliable oral diagnostic fluid for IL-8 and calcium detection in periodontitis.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/ijdr.ijdr_1192_21","type":"journal-article","created":{"date-parts":[[2023,7,6]],"date-time":"2023-07-06T03:34:36Z","timestamp":1688614476000},"page":"45-48","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Evaluation of Salivary IL-8 and Calcium Levels in Postmenopausal Females with and without periodontitis\u2014A Comparative Study"],"prefix":"10.4103","volume":"34","author":[{"given":"Raksha","family":"Potdar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amitha","family":"Ramesh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aparna","family":"Rajesh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R2-10-20240828","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1902\/jop.2002.73.11.1377","article-title":"Mediators of periodontal osseous destruction and remodeling: Principles and implications for diagnosis and therapy","volume":"73","author":"McCauley","year":"2002","journal-title":"J Periodontol"},{"key":"R3-10-20240828","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1016\/S0015-0282(01)02909-0","article-title":"Executive summary: Stages of reproductive aging workshop (STRAW)","volume":"76","author":"Soules","year":"2001","journal-title":"Fertil Steril"},{"key":"R4-10-20240828","doi-asserted-by":"crossref","first-page":"461","DOI":"10.4103\/0976-237X.169846","article-title":"Assessment of salivary calcium, phosphate, magnesium, pH, and flow rate in healthy subjects, periodontitis, and dental caries","volume":"6","author":"Rajesh","year":"2015","journal-title":"Contemp Clin Dent"},{"key":"R5-10-20240828","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s00417-010-1445-3","article-title":"Expression of Orai genes and I (CRAC) activation in the human retinal pigment epithelium","volume":"249","author":"Cordeiro","year":"2011","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"R6-10-20240828","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1177\/00220345870660020601","article-title":"Current diagnostic uses of saliva","volume":"66","author":"Ferguson","year":"1987","journal-title":"J Dent Res"},{"key":"R7-10-20240828","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1177\/154405910608500703","article-title":"Bone remodeling in post-menopausal osteoporosis","volume":"85","author":"Lerner","year":"2006","journal-title":"J Dent Res"},{"key":"R8-10-20240828","doi-asserted-by":"crossref","first-page":"4805","DOI":"10.1210\/jc.2006-1100","article-title":"Association of interleukin-8 with hot flashes in premenopausal, perimenopausal, and postmenopausal women and bilateral oophorectomized women","volume":"91","author":"Yasui","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"R9-10-20240828","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/0006-291X(89)92009-3","article-title":"Neutrophil activating factor (NAF) induces polymorphonuclear leukocyte adherence to endothelial cells and to subendothelial matrix proteins","volume":"162","author":"Carveth","year":"1989","journal-title":"Biochem Biophys Res Commun"},{"key":"R10-10-20240828","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1111\/j.1462-5822.2004.00420.x","article-title":"Candida albicans and streptococcus salivarius modulate il-6, il-8, and tnf-alpha expression and secretion by engineered human oral mucosa cells","volume":"6","author":"Mostefaoui","year":"2004","journal-title":"Cell Microbiol"},{"key":"R11-10-20240828","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1111\/j.1600-0765.2009.01229.x","article-title":"Gingival and periodontal ligament fibroblasts differ in their inflammatory response to viable porphyromonas gingivalis. 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