{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T20:34:11Z","timestamp":1787776451230,"version":"build-2784847793"},"reference-count":19,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Body Mass Index (BMI) percentiles have a bearing on skeletal maturation. The correlation of BMI with serum osteocalcin (OC) and insulin-like growth factor binding protein-3 (IGFBP-3) and cervical vertebral maturation (CVM) assumes even greater importance in orthodontic treatment planning for skeletal Class II jaw discrepancies. The aim of the study was thus to estimate BMI percentiles, serum OC, and IGFBP-3 and correlate it with CVM to assess the opportune pubertal growth spurt.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>\n                      Height and body weight were measured to the BMI percentiles of the study participants with skeletal class II malocclusion (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 51, age 11\u201318 yrs). Lateral cephalometry was used for CVM staging. Blood was collected to quantitatively assess the serum OC and IGFBP-3 levels using Sandwich-ELISA.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Obesity was more common in females compared to males (24% vs. 7.69%) while the reverse was true for underweight (4% vs. 15.39%). The majority of the obese participants belonged to CVM4\u2013CVM6. Mean OC and IGFBP-3 were the highest in the obese category (71.879 \u00b1 5.275 ng\/mL, 55.541 \u00b1 5.795 ng\/mL). No statistically significant difference was observed in the mean OC and IGFBP-3 levels between males and females (64.993 \u00b1 10.929 ng\/mL vs. 58.795 \u00b1 23.054 ng\/mL,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.231: 44.030 \u00b1 12.767 ng\/mL vs. 48.081 \u00b1 10.843 ng\/mL,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.229).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The clinical relevance of serum biomarkers (OC, IGFBP-3) and their correlation with BMI percentile and CVM stages could be certainly used to assess the circumpubertal growth status. Obese and severely obese females, though they belong to the age range of 13\u201317 years and later CVM stages, there was a significant increase in OC and IGFBP-3 serum levels that could be used to plan orthopedic treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijdr.ijdr_266_24","type":"journal-article","created":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T08:03:40Z","timestamp":1748505820000},"page":"49-53","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Correlation of Body Mass Index with Serum Osteocalcin and Insulin-Like Growth Factor Binding Protein-3 in the Assessment of Pubertal Growth Spurt - A Comparative Study"],"prefix":"10.4103","volume":"36","author":[{"given":"Sengodappan Vaibava","family":"Keerthana","sequence":"first","affiliation":[{"name":"Department of Orthodontics and Dentofacial Orthopedics, Sree Balaji Dental College and Hospital, Bharath Institute of Higher Education & Research, Chennai, Tamil Nadu, India"},{"name":"Department of Orthodontics and Dentofacial Orthopedics, RVS Dental College and Hospital, The Tamil Nadu Dr. MGR Medical University, Coimbatore, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arif","family":"Yezdani","sequence":"additional","affiliation":[{"name":"Department of Orthodontics and Dentofacial Orthopedics, Sree Balaji Dental College and Hospital, Bharath Institute of Higher Education & Research, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marugulam Sabapathy","family":"Kannan","sequence":"additional","affiliation":[{"name":"Department of Orthodontics and Dentofacial Orthopedics, Sree Balaji Dental College and Hospital, Bharath Institute of Higher Education & Research, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kesavaram","family":"Padmavathy","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Sree Balaji Dental College and Hospital, Bharath Institute of Higher Education and Research, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,5,28]]},"reference":[{"key":"R1-20250531","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1007\/s00784-022-04773-7","article-title":"Age estimation of children based on open apex measurement in the developing permanent dentition:An Egyptian formula","volume":"27","author":"El-Desouky","year":"2023","journal-title":"Clin Oral Investig"},{"key":"R2-20250531","first-page":"ZC51","article-title":"Assessment of skeletal maturation in concordance to statural height and body weight in 12-year-old children - A cross-sectional study","volume":"10","author":"Krishnamoorthy","year":"2016","journal-title":"J Clin Diagn Res"},{"key":"R3-20250531","first-page":"316","article-title":"An improved version of the cervical vertebral maturation (CVM) method for the assessment of mandibular growth","volume":"72","author":"Baccetti","year":"2002","journal-title":"Angle Orthod"},{"key":"R4-20250531","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/0021-9681(72)90027-6","article-title":"Indices of relative weight and obesity","volume":"25","author":"Keys","year":"9721","journal-title":"J Chronic Dis 1"},{"key":"R5-20250531","doi-asserted-by":"crossref","first-page":"E29","DOI":"10.1542\/peds.102.3.e29","article-title":"Obesity evaluation and treatment:Expert Committee recommendations. 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