{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:23:57Z","timestamp":1787757837508,"version":"build-2784847793"},"reference-count":55,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>An ideal irrigant should exhibit good antimicrobial activity along with smear removal. Various plant extracts have been used for disinfection of the root canal system. The present study aims in evaluating the tissue response and systemic toxicity of ethanolic extract of Morinda citrifolia versus Morinda citrifolia fresh fruit juice in an animal model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>\n                      A total 48 female adult wistar albino rats were randomly allocated into 4 groups as Group I- 3% sodium hypochlorite (n = 12), Group II- Saline (Control) (n = 12), Group III- ethanolic extract of Morinda citrifolia (n = 12), Group IV- Morinda citrifolia Fresh Fruit Juice (n = 12). A trough was made in the periapical bone, and the test sample was placed in the respective groups. The animals were euthanized for 7\n                      <jats:sup>th<\/jats:sup>\n                      day, 14\n                      <jats:sup>th<\/jats:sup>\n                      day and 30\n                      <jats:sup>th<\/jats:sup>\n                      day and the tissue specimen was prepared for histopathological evaluation, and serum analysis was done for oxidative stress markers, liver and renal function tests.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Serum analysis exhibited significant elevation of Alkaline Phosphatase (ALP), Glutathione Peroxidase (GPX) and Glutathione Reductase (GR) and histopathology showed a higher inflammatory response at 7\n                      <jats:sup>th<\/jats:sup>\n                      and 14\n                      <jats:sup>th<\/jats:sup>\n                      days in group II and group III (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.05), as compared to the other groups. At the 30\n                      <jats:sup>th<\/jats:sup>\n                      day time interval, there was no statistically significant difference in serum analysis and inflammatory response, in all the four groups analysed (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &gt; 0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Ethanolic extract of Morinda citrifolia was not biocompatible and more cytotoxic than a Morinda citrifolia fresh fruit juice. So, fresh fruit juice of Morinda citrifolia can be a preferred choice of natural root canal irrigant, with least possible cytotoxic effects as compared to the ethanolic extract.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijdr.ijdr_436_19","type":"journal-article","created":{"date-parts":[[2022,5,18]],"date-time":"2022-05-18T13:31:38Z","timestamp":1652880698000},"page":"423-431","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of Morinda Citrifolia Ethanolic Extract Versus Morinda Citrifolia Fresh Fruit Juice for Tissue Response and Systemic Toxicity in Animal Model"],"prefix":"10.4103","volume":"32","author":[{"given":"Kavalipurapu 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