{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T16:43:02Z","timestamp":1786725782026,"version":"build-2736575974"},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Cancer-associated thrombosis is recognised but rare in oral squamous cell carcinoma (OSCC). We report an unusual case of extensive thrombus involving the internal jugular vein (IJV) extending to the subclavian vein (SV) in OSCC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Details:<\/jats:title>\n                    <jats:p>A 53-year-old female presented with facial swelling and trismus. Imaging revealed OSCC of the left mandible with extensive lymph node involvement and a large thrombus in left IJV, extending to the SV. She was referred to a higher centre for thrombus management and OSCC treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Diagnosis:<\/jats:title>\n                    <jats:p>Computed tomography (CT) and positron emission tomography\u2013CT\/magnetic resonance imaging fusion confirmed OSCC with thrombus extending from IJV to SV.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion:<\/jats:title>\n                    <jats:p>Thrombus development in OSCC is multifactorial. This case highlights the potential for extensive venous thromboembolism in OSCC, with rare extension into SV.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Extensive venous thromboembolism in OSCC, with thrombus extension into SV, is a rare but critical complication. Vigilant surveillance and a multi-disciplinary approach are essential.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijdr.ijdr_461_25","type":"journal-article","created":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T14:00:23Z","timestamp":1767362423000},"page":"370-373","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Migratory Thrombosis of Internal Jugular Vein in Oral Squamous Cell Carcinoma \u2013 A Case Report"],"prefix":"10.4103","volume":"36","author":[{"given":"S. M.","family":"Balaji","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Balaji Dental and Craniofacial Hospital, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Preetha","family":"Balaji","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Balaji Dental and Craniofacial Hospital, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,1,2]]},"reference":[{"key":"R1-20260121","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/s13256-018-1833-6","article-title":"Trousseau syndrome in a patient with advanced oral squamous cell carcinoma: A case report","volume":"13","author":"Aoyama","year":"2019","journal-title":"J Med Case Rep"},{"key":"R2-20260121","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s13691-020-00440-4","article-title":"An autopsy case of Trousseau's syndrome with tumor thrombosis in unknown primary squamous cell carcinoma of the head and neck","volume":"10","author":"Uraguchi","year":"2021","journal-title":"Int Cancer Conf J"},{"key":"R3-20260121","doi-asserted-by":"crossref","first-page":"5616","DOI":"10.3390\/cancers14225616","article-title":"Oral squamous cell carcinoma-associated thrombosis: What evidence?","volume":"14","author":"Di Gennaro","year":"2022","journal-title":"Cancers"},{"key":"R4-20260121","doi-asserted-by":"crossref","first-page":"2838","DOI":"10.3390\/ijms20112838","article-title":"Thrombosis risk associated with head and neck cancer: A review","volume":"20","author":"Haen","year":"2019","journal-title":"Int J Mol Sci"},{"key":"R5-20260121","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1016\/j.ejso.2021.02.021","article-title":"Occlusion of the internal jugular vein in differentiated thyroid carcinoma: Causes and diagnosis","volume":"47","author":"Hartl","year":"2021","journal-title":"Eur J Surg Oncol"},{"key":"R6-20260121","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s10006-016-0600-3","article-title":"Massive internal jugular vein tumor thrombus derived from squamous cell carcinoma of the head and neck: Two case reports","volume":"21","author":"Wakasaki","year":"2017","journal-title":"Oral Maxillofac Surg"},{"key":"R7-20260121","doi-asserted-by":"crossref","first-page":"1","DOI":"10.47363\/JOLRR\/2022(1)102","article-title":"Facial vein thrombosis in head and neck squamaous cell carcinoma with review-A rare case report","volume":"1","author":"Rawat","year":"2022","journal-title":"J Otolaryngol Res Rep"},{"key":"R8-20260121","doi-asserted-by":"crossref","first-page":"101425","DOI":"10.1016\/j.bjorl.2024.101425","article-title":"Internal jugular vein thrombosis caused by invasive pharyngeal cancer: A case report and literature review","volume":"90","author":"Tudor","year":"2024","journal-title":"Braz J Otorhinolaryngol"},{"key":"R9-20260121","doi-asserted-by":"crossref","first-page":"166","DOI":"10.25259\/FH_48_2024","article-title":"Oral cavity squamous cell carcinoma complicated by internal jugular vein thrombosis","volume":"2","author":"Verma","year":"2024","journal-title":"Future Health"},{"key":"R10-20260121","doi-asserted-by":"crossref","first-page":"460","DOI":"10.3390\/cancers14020460","article-title":"Molecular landscape of the coagulome of oral squamous cell carcinoma","volume":"14","author":"Lottin","year":"2022","journal-title":"Cancers (Basel)"}],"container-title":["Indian Journal of Dental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ijdr.ijdr_461_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T16:25:33Z","timestamp":1786724733000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ijdr.ijdr_461_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":10,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/ijdr.ijdr_461_25","relation":{},"ISSN":["0970-9290","1998-3603"],"issn-type":[{"value":"0970-9290","type":"print"},{"value":"1998-3603","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"2025-06-30","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-07","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}