{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:02:18Z","timestamp":1790787738372,"version":"4.1.0"},"reference-count":12,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Treatment modalities for cancer including surgery, radiotherapy and chemotherapy, have some complications even in the oral cavity. The literature describes oral lesions that may arise as a result of chemotherapy. However, information regarding oral symptoms in advanced cancer patients is poor.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To identify the oral manifestations like oral mucositis, dry mouth and loss of taste in patients undergoing chemotherapy treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We evaluated 60 patients affected by malignancy undergoing chemotherapy treatment. The clinical and pathological data such as age, gender, diagnosis of malignancy and types of treatments with anticancer chemotherapeutic drug treatment, were obtained. Patients were routinely evaluated for the presence of oral mucositis based on the Common Terminology Criteria for Adverse Events (CTCAE) v5.0 scale for adverse effects and graded. Other findings like dry mouth and loss of taste were recorded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Of the 60 patients, 40 (66.6%) were male, and 20 (33.3%) females with a mean age of 53.7 years. Most patients about 63% and 83% were diagnosed with dry mouth and loss of taste, respectively and 71% of patients had mucositis. Chemotherapy drugs like Cyclophosphamide, carboplatin, nanoxel, paclitaxel, oxaliplatin, docetaxel and doxorubicin, were directly associated with oral mucositis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Patients treated with chemotherapy for cancer most often suffer from a multitude of intense and debilitating oral dysfunctions. Oral lesions found in patients undergoing chemotherapy were mucositis, dry mouth and loss of taste. These adverse effects and an appropriate symptomatic therapy need to be discussed with the patients. Chemotherapy has a significant but transient effect on the oral symptoms.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijdr.ijdr_516_23","type":"journal-article","created":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T21:53:09Z","timestamp":1724363589000},"page":"126-130","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":5,"title":["Oral Risk Factors in Patients with Cancer Undergoing Chemotherapy - A Pilot Study"],"prefix":"10.4103","volume":"35","author":[{"given":"Anupama","family":"Aradya","sequence":"first","affiliation":[{"name":"Department of Prosthodontics, JSS Dental College and Hospital, JSS Academy of Higher Education and Research, Mysore, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. K.","family":"Kiran","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, JSS Medical College and Hospital, JSS Academy of Higher Education and Research, Mysore, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. N.","family":"Raghavendra Swamy","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics, JSS Dental College and Hospital, JSS Academy of Higher Education and Research, Mysore, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vidya G.","family":"Doddawad","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology and Microbiology, JSS Dental College and Hospital, Mysore, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narahari","family":"Ranganatha","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Rajarajeswari Dental College and Hospital, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koduru","family":"Sravani","sequence":"additional","affiliation":[{"name":"Department of Periodontics, Dayanand Sagar College of Dental Sciences, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,8,22]]},"reference":[{"key":"R1-20241009","doi-asserted-by":"crossref","first-page":"3249","DOI":"10.1007\/s00520-015-2720-y","article-title":"Prevalence of oral mucositis, dry mouth, and dysphagia in advanced cancer patients","volume":"23","author":"Mercadante","year":"2015","journal-title":"Support Care Cancer"},{"key":"R2-20241009","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.2174\/1381612822666160216150812","article-title":"Smell and taste disorders resulting from cancer and chemotherapy","volume":"22","author":"Cohen","year":"2016","journal-title":"Curr Pharm Des"},{"key":"R3-20241009","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.ad.2019.05.009","article-title":"Using the common terminology criteria for adverse events (CTCAE-version 5.0) to evaluate the severity of adverse events of anticancer 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Oncol"},{"key":"R11-20241009","doi-asserted-by":"crossref","first-page":"e0267092","DOI":"10.1371\/journal.pone.0267092","article-title":"Salivary inflammatory mediators as biomarkers for oral mucositis and oral mucosal dryness in cancer patients:A pilot study","volume":"17","author":"Kiyomi","year":"2022","journal-title":"PLoS One"},{"key":"R12-20241009","doi-asserted-by":"crossref","first-page":"86","DOI":"10.4103\/ams.ams_136_20","article-title":"Cancer chemotherapy-induced oral adverse events:Oral dysesthesia and toothache-A retrospective study","volume":"11","author":"Hino","year":"2021","journal-title":"Ann Maxillofac Surg"}],"container-title":["Indian Journal of Dental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ijdr.ijdr_516_23","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T20:06:28Z","timestamp":1787774788000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ijdr.ijdr_516_23"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":12,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.4103\/ijdr.ijdr_516_23","relation":{},"ISSN":["0970-9290","1998-3603"],"issn-type":[{"value":"0970-9290","type":"print"},{"value":"1998-3603","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4]]},"assertion":[{"value":"2023-06-08","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-19","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}