{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T20:23:34Z","timestamp":1787775814529,"version":"build-2784847793"},"reference-count":18,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Menopause is a normal developmental stage in a woman\u2019s life marking the permanent cessation of menstruation. Periodontitis and osteoporosis are noteworthy health concerns in post-menopausal women. Calprotectin is an inflammatory biomarker for precise diagnosis of periodontal disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>This study was performed to evaluate the variations in salivary calprotectin levels and bone mineral density in post-menopausal women with and without chronic periodontitis. The study included 24 post-menopausal women aged 45-57 years and was divided into group 1 (12 post-menopausal women without chronic periodontitis) and group 2 (12 post-menopausal women with chronic periodontitis). Unstimulated salivary samples, panoramic radiographs and clinical examination were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The collected samples were combined with CALPRO antibody with horseradish peroxide (HRP) that results in the formation of antigen-antibody complex. Tetramethylbenzidine (TMB) solution was added that turned blue. Colour change was measured at 450nm. A human ELISA kit was used. Data collected were sent for statistical analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion:<\/jats:title>\n                    <jats:p>\n                      There was a statistically significant difference in salivary calprotectin levels between groups 1 and 2 (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.016) and no statistical difference in mean bone mineral density levels between the two groups (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.235). A positive correlation was seen between salivary calprotectin levels and bone mineral density in group 2 (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.013).\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijdr.ijdr_522_21","type":"journal-article","created":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T07:03:14Z","timestamp":1726470194000},"page":"140-144","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Salivary Calprotectin Levels and Bone Mineral Density in Post-Menopausal Women With and Without Chronic Periodontitis - An Evaluative Study"],"prefix":"10.4103","volume":"35","author":[{"given":"J","family":"Pavithra","sequence":"first","affiliation":[{"name":"Department of Periodontology, A B Shetty Memorial Institute of Dental Sciences, Mangalore, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amitha","family":"Ramesh","sequence":"additional","affiliation":[{"name":"Department of Periodontology, A B Shetty Memorial Institute of Dental Sciences, Mangalore, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biju","family":"Thomas","sequence":"additional","affiliation":[{"name":"Department of Periodontology, A B Shetty Memorial Institute of Dental Sciences, Mangalore, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N Suchetha","family":"Kumari","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, K S Hegde Medical Academy, Mangalore, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. 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