{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T20:39:54Z","timestamp":1786653594751,"version":"build-2736575974"},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:sec>\n                    <jats:title>Context:<\/jats:title>\n                    <jats:p>The role of platelet parameters as markers of inflammation in various diseases is now in limelight. The interaction between cancer cells and platelets is a well-established phenomenon. Oral submucous fibrosis (OSMF) is a premalignant disorder with a malignant transformation rate of 2\u20138%. This study aimed to evaluate platelet parameters in OSMF and oral squamous cell carcinoma (OSCC) in the background of OSMF. This cross-sectional study was performed using secondary data retrieved between January 2019 and December 2019 in the Department of Oral Pathology and the Hematology Laboratory.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Materials:<\/jats:title>\n                    <jats:p>The data retrieved included 44 histopathologically proven OSCC in a background of OSMF (group III) and 36 OSMF (group II). The haematological parameters of these selected cases were retrieved from the Sysmex XN-1000 automated hematology analyser database. A control group (group I) comprises 50 subjects with normal (negative\/unflagged) haematological parameters. All data were statistically analysed using SPSS 20.0. The significance level of tests was set at 5%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The mean platelet volume (MPV) (9.60 [\u00b10.95]\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001), platelet distribution width (PDW) (10.45 [\u00b11.9],\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001), platelet large cell ratio (PLCR) (21.70 [\u00b17.98],\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001), and the ratio of mean platelet volume to total platelet count (MPV\/PLT) (0.03 [0.01],\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001) were lower in group III when compared to the other two groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Platelet parameters may be used as indices in the OSCC in the background of OSMF. However, large-scale prospective studies are necessary to evaluate the utility of these parameters during the malignant transformation of OSMF, thereby encouraging prompt treatment to prevent morbidity and mortality.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijdr.ijdr_538_23","type":"journal-article","created":{"date-parts":[[2024,4,20]],"date-time":"2024-04-20T12:00:33Z","timestamp":1713614433000},"page":"417-421","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Evaluation of Platelet Parameters in Oral Submucous Fibrosis and Oral Squamous Cell Carcinoma in a Background of Oral Submucous Fibrosis"],"prefix":"10.4103","volume":"34","author":[{"given":"Packiaraj Selvajothi","family":"Ranjitham","sequence":"first","affiliation":[{"name":"Department of Oral Pathology, Tamil Nadu Government Dental College and Hospital, Affiliated to Tamil Nadu Dr. MGR Medical University, Chennai, Tamil Nadu, 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