{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T13:08:04Z","timestamp":1789391284207,"version":"build-2803163510"},"reference-count":17,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,1]]},"abstract":"Abstract<\/jats:title>\n \n Aims:<\/jats:title>\n To comparatively evaluate the effect of normal saline gel and ozonated saline-ozonated gel (ozone therapy) on pain, inflammation, soft tissue, and crestal bone loss in dental implant surgery.<\/jats:p>\n <\/jats:sec>\n \n Methods and Material:<\/jats:title>\n \n Forty adult patients scheduled to undergo implant were randomized into two groups: Twenty patients (\n n<\/jats:italic>\n = 20) received ozone therapy and controls (\n n<\/jats:italic>\n = 20) received normal saline and gel during implant placement. Inflammation and pain were noted at days 1 and 7 and 3 month intervals by estimating C-reactive protein (CRP) levels and assessing visual analogue scale (VAS) scores. At 3 months, soft tissue outcomes were noted in terms of plaque index, gingival index, and pocket depth, while crestal bone loss was noted via a radiograph.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Mean CRP levels were significantly higher in the control group as compared to that in the case group on day 1 and day 7 follow-ups (\n P<\/jats:italic>\n < 0.05). Mean VAS scores for pain were also lower in the case group as compared to the control group at all follow-ups, but the difference was significant statistically only at day 1 (\n P<\/jats:italic>\n = 0.061). The plaque index was significantly lower in the case group as compared to the control group (\n P<\/jats:italic>\n = 0.011) at final follow-up. No significant difference between two groups was observed for crestal bone loss.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n Ozone therapy during implant placement was effective in reduction of pain, systemic inflammation, and plaque deposition in dental implant patients.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/ijdr.ijdr_591_23","type":"journal-article","created":{"date-parts":[[2024,6,22]],"date-time":"2024-06-22T08:01:20Z","timestamp":1719043280000},"page":"2-6","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Comparative Evaluation of Normal Saline Gel and Ozone Therapy on Soft and Hard Tissue Health in Dental Implant Surgery"],"prefix":"10.4103","volume":"35","author":[{"given":"Abhay","family":"Dixit","sequence":"first","affiliation":[{"name":"Department of Prosthodontics, King George\u2019s Medical University, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhaskar","family":"Agarwal","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics, King George\u2019s Medical University, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamleshwar","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics, King George\u2019s Medical University, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pooran","family":"Chand","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics, King George\u2019s Medical University, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jitendra","family":"Rao","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics, King George\u2019s Medical University, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niraj","family":"Mishra","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics, King George\u2019s Medical University, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,6,20]]},"reference":[{"key":"R1-20260914","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1034\/j.1600-0501.2000.011004354.x","article-title":"Pulsed electromagnetic fields promote bone formation around dental implants inserted into the femur of rabbits","volume":"11","author":"Matsumoto","year":"2000","journal-title":"Clin Oral Implants Res"},{"key":"R2-20260914","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1034\/j.1600-0501.2003.00872.x","article-title":"Osseointegration of endosseous ceramic implants after postoperative low-power laser stimulation: An in vivo comparative study","volume":"14","author":"Guzzardella","year":"2003","journal-title":"Clin Oral Implants Res"},{"key":"R3-20260914","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1034\/j.1600-0501.2003.140307.x","article-title":"Solcoseryl, a tissue respiration stimulating agent, significantly enhances the effect of capacitively coupled electric field on the promotion of bone formation around dental Implants","volume":"14","author":"Ochi","year":"2003","journal-title":"Clin Oral Implants Res"},{"key":"R4-20260914","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.11607\/jomi.3168","article-title":"The effect of subgingival ozone and\/or hydrogen peroxide on the development of peri-implant mucositis: A double-blind randomized controlled trial","volume":"28","author":"McKenna","year":"2013","journal-title":"Int J Oral Maxillofac Implants"},{"key":"R6-20260914","first-page":"28","article-title":"Practical use of ozone in dentistry-Comments","volume":"63","author":"Teresa","year":"2008","journal-title":"Ann Univ Mariae Curie Sklodowska Lubin Polonia"},{"key":"R7-20260914","first-page":"5","article-title":"Ozone and its usage in general medicine and dentistry. A review article","volume":"109","author":"Seidler","year":"2008","journal-title":"Prague Med Rep"},{"key":"R8-20260914","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1007\/s00784-011-0603-2","article-title":"Influence of gaseous ozone in peri-implantitis: Bactericidal efficacy and cellular response. An in vitro study using titanium and zirconia","volume":"16","author":"Hauser-Gerspach","year":"2012","journal-title":"Clin Oral Investig"},{"key":"R9-20260914","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1563\/AAID-JOI-D-09-00098","article-title":"Evaluation of the effect of ozonated plant oils on the quality of osseointegration of dental implants under the influence of Cyclosporin A: An in vivo study","volume":"37","author":"El Hadary","year":"2011","journal-title":"J Oral Implantol"},{"key":"R10-20260914","doi-asserted-by":"crossref","first-page":"136","DOI":"10.5051\/jpis.2018.48.3.136","article-title":"The effects of ozone therapy as an adjunct to the surgical treatment of peri-implantitis","volume":"48","author":"Isler","year":"2018","journal-title":"J Periodontal Implant Sci"},{"key":"R11-20260914","doi-asserted-by":"crossref","first-page":"703","DOI":"10.4103\/njcp.njcp_82_17","article-title":"Is Low-level laser therapy and gaseous ozone application effective on osseointegration of immediately loaded implants?","volume":"21","author":"Karaca","year":"2018","journal-title":"Niger J Clin Pract"},{"key":"R12-20260914","doi-asserted-by":"crossref","first-page":"126","DOI":"10.4103\/0975-5950.154813","article-title":"A radiological evaluation of marginal bone around dental implants: An in-vivo study","volume":"5","author":"Nandal","year":"2014","journal-title":"Natl J Maxillofac Surg"},{"key":"R13-20260914","first-page":"e64507","article-title":"Ozone decreases biomarkers of inflamation (c-reactive protein and erytrocyte sedimentation rate) and improves pain, function and quality of life in knee osteoarthrtitis patients: A before-and-after study and review of the literature Middle East J Rehabil Health Stud","volume":"5","author":"Fernandez-Cuadros","year":"2018"},{"key":"R14-20260914","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/2045-9912-1-29","article-title":"Mechanisms of action involved in ozone therapy: Is healing induced via a mild oxidative stress?","volume":"1","author":"Sagai","year":"2011","journal-title":"Med Gas Res"},{"key":"R15-20260914","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1902\/jop.2016.150217","article-title":"Effects of ozone therapy on the early healing period of deepithelialized gingival grafts: A randomized placebo-controlled clinical trial","volume":"87","author":"Ta\u015fdemir","year":"2016","journal-title":"J Periodontol"},{"key":"R16-20260914","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2021.107588","article-title":"An evaluation of the effect of ozone therapy on tissues surrounding dental implants","volume":"96","author":"Shekhar","year":"2021","journal-title":"Int Immunopharmacol"},{"key":"R17-20260914","first-page":"51","article-title":"Clinical and radiographic evaluation the effect of ozone therapy on tissue surrounding implant retained mandibular overdentures","volume":"6","author":"Matar","year":"2016","journal-title":"Revista Espa\u00f1ola de Ozonoterapia"},{"key":"R18-20260914","doi-asserted-by":"crossref","first-page":"295","DOI":"10.4317\/medoral.19536","article-title":"Single-blind randomized clinical trial to evaluate clinical and radiological outcomes after one year of immediate versus delayed implant placement supporting full-arch prostheses","volume":"19","author":"Pellicer-Chover","year":"2014","journal-title":"Med Oral Patol Oral Cir Bucal"}],"container-title":["Indian Journal of Dental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ijdr.ijdr_591_23","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T13:00:16Z","timestamp":1789390816000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ijdr.ijdr_591_23"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":17,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.4103\/ijdr.ijdr_591_23","relation":{},"ISSN":["0970-9290","1998-3603"],"issn-type":[{"value":"0970-9290","type":"print"},{"value":"1998-3603","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"2023-07-07","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-30","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}