{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:33:31Z","timestamp":1787070811235,"version":"build-2736575974"},"reference-count":16,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim and Objectives:<\/jats:title>\n                    <jats:p>Quantitative evaluation and comparison of Cyclin D1 expression in various histological grades of oral epithelial dysplasia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods:<\/jats:title>\n                    <jats:p>\n                      A total of 66 instances of oral epithelial dysplasia were included, with a histological diagnosis, consisting of 22 cases for each of the three histopathological grades. These cases were evaluated for cyclin D1 expression using immunohistochemistry techniques. To compare the average number of positive cells among the three groups with epithelial dysplasia, the Tukey\u2019s multiple\n                      <jats:italic toggle=\"yes\">post hoc<\/jats:italic>\n                      method and the one-way ANOVA test were utilized. A\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      value of 0.05 or less was considered statistically significant.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The expression of Cyclin D1 protein has been shown to vary significantly across mild, moderate, and severe epithelial dysplasia, with the group exhibiting severe oral epithelial dysplasia (OED) showing the highest average levels of expression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The overproduction of cyclin D1 in individuals with severe epithelial dysplasia suggests that it could serve as a precursor to the onset of oral cancer. Cyclin D1 may act as a potential predictive marker for malignant transformation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijdr.ijdr_592_25","type":"journal-article","created":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T09:00:09Z","timestamp":1771491609000},"page":"439-443","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Assessment and Comparison of Cyclin D1 Expression in Different Histopathological Grades of Oral Epithelial Dysplasia - An In vitro Study"],"prefix":"10.4103","volume":"36","author":[{"given":"Sanjana","family":"Lingampalli","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Pathology and Oral Microbiology, St Alosiyus Dental Clinic, Gunadala, Vijayawada, Andhra Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiran K.","family":"Kattappagari","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Pathology, SIBAR Institute of Dental Sciences, Guntur, Andhra Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Poosarla","family":"Chandrashekar","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Pathology, SIBAR Institute of Dental Sciences, Guntur, Andhra Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vatsalya","family":"Kommalapati","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Pathology, SIBAR Institute of Dental Sciences, Guntur, Andhra Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kantheti L. 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