{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T13:09:30Z","timestamp":1789391370752,"version":"build-2803163510"},"reference-count":8,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims:<\/jats:title>\n                    <jats:p>Compare the efficacy of 2% lidocaine with adrenaline (1:200,000) and 4% articaine with adrenaline (1:100,000) in inferior alveolar nerve block prior to extraction of bilateral teeth posterior to canine in interval of one week.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Material:<\/jats:title>\n                    <jats:p>Thirty-five patients were selected for the study. Patients were divided into two different groups: Group 1 \u2013 (2% lignocaine with adrenaline (1:200,000)) and Group 2 \u2013 (4% articaine with adrenaline (1:100,000)) solution. The study variables for each anaesthetic agent were: onset of action and depth of anaesthesia. A pulp tester was used to demonstrate quantitative values and a visual analogue scale (VAS) was used for qualitative evaluation of the two anaesthetic drugs in 2 min cycle for 10 min with respect to test canine. Anaesthesia was considered successful when pulp tester value 64 was achieved in 10 min for both the anaesthetic agent.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Statistical Analysis Used:<\/jats:title>\n                    <jats:p>\n                      The difference in the efficacy of lignocaine and articaine was analysed using Student\u2019s\n                      <jats:italic toggle=\"yes\">t<\/jats:italic>\n                      test. Within group comparison of the response to the pulp vitality test and VAS over various time periods was analysed using repeated measures Analysis of Variance (ANOVA) with post-hoc Bonferroni test.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Data analysis showed statistical differences in onset and depth of anaesthesia between the two groups (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>4% Articaine with adrenaline (1:100,000) onset of action is faster and depth of anaesthesia is better compared to 2% lignocaine with adrenaline (1:200,000). Many previous studies reported onset of anaesthesia, but this study evaluates onset and depth of both the anaesthetic agent quantitatively and qualitatively.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijdr.ijdr_678_23","type":"journal-article","created":{"date-parts":[[2024,6,22]],"date-time":"2024-06-22T08:01:03Z","timestamp":1719043263000},"page":"40-44","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Efficacy for Lidocaine and Articaine in Inferior Alveolar Nerve Block - A Comparative Study"],"prefix":"10.4103","volume":"35","author":[{"given":"Rakhi S.","family":"Purkayastha","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, YMT Dental College and Hospital, Navi Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samir","family":"Joshi","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Bharati Vidyapeeth Dental College and Hospital, Pune, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krishnanunni","family":"Nair","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Oncology, D Y Patil Hospital, Navi Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudhir","family":"Pawar","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Bharati Vidyapeeth Dental College and Hospital, Pune, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,6,20]]},"reference":[{"key":"R1-20260914","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s12663-012-0368-4","article-title":"Efficacy of 4% Articaine and 2% Lidocaine: A clinical study","volume":"12","author":"Kambalimath","year":"2013","journal-title":"J Maxillofac Oral Surg"},{"key":"R2-20260914","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.coms.2013.03.003","article-title":"Pharmacology of local anesthetics used in oral surgery","volume":"25","author":"Giovannitti","year":"2013","journal-title":"Oral Maxillofac Surg Clin North Am"},{"issue":"190","key":"R4-20260914","first-page":"15","article-title":"Articaine - the best choice of local anesthetic in contemporary dentistry","author":"Nizharadze","year":"2011","journal-title":"Georgian Medical News"},{"key":"R6-20260914","doi-asserted-by":"crossref","first-page":"356","DOI":"10.4103\/0259-1162.171445","article-title":"Anesthetic efficacy of 4% articaine versus 2% lignocaine during the surgical removal of the third molar: A comparative prospective study","volume":"10","author":"Jain","year":"2016","journal-title":"Anesth Essays Res"},{"key":"R7-20260914","first-page":"19","article-title":"Comparative evaluation of onset and duration of anaesthesia of 4% articaine versus 2% lidocaine with epinephrine 1: 1,00,000 during exodontia","volume":"1","author":"Kalia","year":"2011","journal-title":"Indian J Compr Dent Care"},{"key":"R9-20260914","doi-asserted-by":"crossref","first-page":"177","DOI":"10.14219\/jada.archive.2001.0152","article-title":"Articaine hydrochloride: The study of safety of a new amide local anesthetic","volume":"132","author":"Malamed","year":"2001","journal-title":"J Am Dent Assc"},{"key":"R10-20260914","first-page":"307","article-title":"A comparison between articaine HCL and lidocaine HCL in pediatric dental patients","volume":"22","author":"Malamed","year":"2000","journal-title":"Pediatr Dent"},{"key":"R11-20260914","doi-asserted-by":"crossref","first-page":"236","DOI":"10.4103\/ams.ams_416_20","article-title":"To evaluate the Efficacy of Buprenorphine and 2% Lignocaine with adrenaline as postoperative analgesia following mandibular third molar surgery: A comparative study","volume":"11","author":"Bagade","year":"2021","journal-title":"Ann Maxillofac Surg"}],"container-title":["Indian Journal of Dental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ijdr.ijdr_678_23","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T13:00:29Z","timestamp":1789390829000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ijdr.ijdr_678_23"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":8,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.4103\/ijdr.ijdr_678_23","relation":{},"ISSN":["0970-9290","1998-3603"],"issn-type":[{"value":"0970-9290","type":"print"},{"value":"1998-3603","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"2023-08-03","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-19","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}