{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T20:05:12Z","timestamp":1787169912695,"version":"build-2736575974"},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>Squamous cell carcinoma (SCC) is commonly seen malignant epithelial neoplasm of the oral cavity, which is characterized by variable clinical manifestations. It arises from dysplastic squamous epithelium. Majority of the spread of oral SCC (OSCC) to mandibular bone occurs by direct infiltration of the tumour through alveolar ridge or lingual cortical plate. Only 6% of the OSCC present with primary tumour; hence, a comprehensive whole body imaging needs to be done for ruling out primary tumour anywhere else in the body along with a proper clinical examination. Here, we present an unusual case of long-standing aggressive primary malignancy with unusual clinical presentation in mandibular anterior region associated with chronic tobacco chewing in a 65-year-old male patient.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijdr.ijdr_700_19","type":"journal-article","created":{"date-parts":[[2021,11,22]],"date-time":"2021-11-22T10:42:21Z","timestamp":1637577741000},"page":"256-260","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Squamous Cell Carcinoma of Mandible with Unusual Clinical Presentation"],"prefix":"10.4103","volume":"32","author":[{"given":"Pradhuman","family":"Verma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Muzammil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Preneet","family":"Kaur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhafer S","family":"Al Asmari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R2-22-20240828","doi-asserted-by":"crossref","first-page":"283","DOI":"10.2310\/7070.2001.19563","article-title":"Management of neck in NO Squamous carcinoma cell of the oral cavity","volume":"30","author":"Kramer","year":"2001","journal-title":"J Otololaryngology"},{"key":"R3-22-20240828","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/0964-1955(93)90056-K","article-title":"Epidermoid carcinoma originating from the gingival sulcus","volume":"29","author":"Tajima","year":"1993","journal-title":"Oral Oncol Eur J Cancer"},{"key":"R4-22-20240828","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/0964-1955(93)90049-K","article-title":"Relationship of tobacco\/alcohol use of p53 expression in patients with lingual squamous cell carcinomas","volume":"29","author":"Metthews","year":"1993","journal-title":"Oral Oncol Eur J Cancer"},{"key":"R6-22-20240828","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/0002-9610(64)90144-8","article-title":"The periosteum of the mandible and the intra oral carcinoma","volume":"108","author":"Marchetta","year":"1964","journal-title":"Am J Surg"},{"key":"R7-22-20240828","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1002\/hed.2880160204","article-title":"Predictors of carcinomatous invasion of the mandible","volume":"16","author":"Tsue","year":"1994","journal-title":"Head Neck"},{"key":"R8-22-20240828","doi-asserted-by":"crossref","first-page":"133","DOI":"10.5125\/jkaoms.2016.42.3.133","article-title":"Muscular invasion of squamous cell carcinoma of the posterior mandibular alveolar ridge is associated with cervical lymph node metastasis","volume":"42","author":"Min","year":"2016","journal-title":"J Korean Assoc Oral Maxillofac Surg"},{"key":"R9-22-20240828","doi-asserted-by":"crossref","first-page":"12830","DOI":"10.4103\/0019-509X.44071","article-title":"Squamous cell carcinoma of tongue in a 19 yearold female","volume":"45","author":"Randhawa","year":"2008","journal-title":"Indian J Cancer"},{"key":"R10-22-20240828","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.ijom.2003.10.006","article-title":"Mandibular invasion in oral squamous cell carcinoma: Investigation by clinical examination and orthopantomogram","volume":"33","author":"Rao","year":"2004","journal-title":"Int J Oral Maxillofac Surg"},{"key":"R12-22-20240828","doi-asserted-by":"crossref","first-page":"438","DOI":"10.4103\/0973-1482.92012","article-title":"Bone invasion in oral cancer patients: A comparison between Orthopantamograph, conventional computed tomography, and single positron emission computed tomography","volume":"7","author":"Kushraj","year":"2011","journal-title":"J Cancer Res Ther"},{"key":"R13-22-20240828","first-page":"18","article-title":"Sentinel lymph node biopsy in squamous cell carcinoma of the head and neck: 10 years of experience","volume":"32","author":"Antonio","year":"2012","journal-title":"Acta Otorhinolaryngol Ital"},{"key":"R14-22-20240828","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/j.jcms.2016.02.003","article-title":"Diagnosing oral squamous cell carcinoma: How much imaging dose really need? 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