{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T05:32:47Z","timestamp":1791437567039,"version":"4.3.3"},"reference-count":13,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>\n                      The remineralization potential of three recent remineralizing agents on white spot lesions\n                      <jats:bold>(<\/jats:bold>\n                      WSLs\n                      <jats:bold>)<\/jats:bold>\n                      was compared and evaluated using the Vicker\u2019s microhardness testing machine. This short study aims to evaluate and compare the remineralization potential of recently introduced remineralizing agents like Curodont Protect gel, GC Tooth Mousse Plus, and Dente 91 on the surface hardness of WSLs in human teeth.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Materials:<\/jats:title>\n                    <jats:p>\n                      Thirty single-rooted human premolars (BBDCODS\/IEC\/09\n                      <jats:bold>\/<\/jats:bold>\n                      2022), extracted due to periodontal or orthodontic reasons, were chosen for this study. The teeth were decoronated at the cemento-enamel junction level. Samples were then mounted in auto-polymerization acrylic resin. All the groups were subjected to a demineralization process to induce WSLs. A post-demineralization Vicker hardness test was performed, followed by random allocation to the three groups. The three groups were namely self-assembling peptide (P11-4), casein phosphopeptide-amorphous calcium phosphate (CPP-ACP), and nanohydroxyapatite. A post-remineralization Vickers hardness test was conducted to evaluate the remineralization potential of the tested agents.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Result:<\/jats:title>\n                    <jats:p>An analysis of variance was performed to determine the significant difference in Vickers microhardness. Self-assembling peptide (P11-4) showed the highest microhardness value.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Self-assembling peptide (Curodont Protect gel) was more efficient than nanohydroxyapatite (Dente-91) and CPP-ACP (GC Tooth Mousse Plus) for the prevention of WSLs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijdr.ijdr_880_23","type":"journal-article","created":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T16:01:07Z","timestamp":1755532867000},"page":"340-343","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["A Comparative Evaluation of Biomimetic Remineralization Potential of Enamel White Spot Lesions - An In Vitro Study"],"prefix":"10.4103","volume":"36","author":[{"given":"Priyanka","family":"Mahajan","sequence":"first","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, Sudha Rustagi College of Dental Science and Research, Faridabad, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,8,14]]},"reference":[{"key":"R1-20260121","first-page":"12","article-title":"Effect of two methods of remineralization and resin infiltration on surface hardness of artificially induced enamel lesions","volume":"21","author":"Behrouzi","year":"2020","journal-title":"J Dent (Shiraz)"},{"key":"R2-20260121","doi-asserted-by":"crossref","first-page":"939","DOI":"10.5005\/jp-journals-10024-3095","article-title":"Analysis of remineralization potential of three different remineralizing pastes on demineralized enamel: A comparative study","volume":"22","author":"Dixit","year":"2021","journal-title":"J Contemp Dent Pract"},{"key":"R3-20260121","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1016\/j.ijbiomac.2021.06.028","article-title":"Enamel-like tissue regeneration by using biomimetic enamel matrix proteins","volume":"183","author":"Fang","year":"2021","journal-title":"Int J Biol Macromol"},{"key":"R4-20260121","first-page":"107","article-title":"Comparative evaluation of remineralization of white spot lesion in nano silver fluoride and nano hydroxyapatite varnish an in vitro study","volume":"10","author":"Sankaranarayanan","year":"2022","journal-title":"J Res Med Dent Sci"},{"key":"R5-20260121","first-page":"7256056","article-title":"Nano-hydroxyapatite gel and its effects on remineralization of artificial carious lesions","author":"Juntavee","year":"2021","journal-title":"Int J Dent 2021"},{"key":"R6-20260121","first-page":"e3059","article-title":"Comparative evaluation of the remineralization potential of monofluorophosphate, Casein phosphopeptide-Amorphous calcium phosphate and calcium sodium phosphosilicate on demineralized enamel lesions: An In Vitro Study","volume":"10","author":"Kumar","year":"2018","journal-title":"Cureus"},{"key":"R7-20260121","doi-asserted-by":"crossref","first-page":"S7","DOI":"10.4103\/jpbs.jpbs_836_21","article-title":"Effect of remineralization agents on white spot lesions a systematic review","volume":"14","author":"Rajendran","year":"2022","journal-title":"J Pharm Bioallied Sci"},{"key":"R8-20260121","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1177\/154405910708600507","article-title":"Self-assembling peptide scaffolds promote enamel remineralization","volume":"86","author":"Kirkham","year":"2007","journal-title":"J Dent Res"},{"key":"R9-20260121","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1002\/sca.21276","article-title":"Effect of self-assembling peptide P11-4 on enamel erosion: AFM and SEM studies","volume":"38","author":"Ceci","year":"2016","journal-title":"Scanning"},{"key":"R10-20260121","doi-asserted-by":"crossref","first-page":"142","DOI":"10.3109\/00016357.2015.1066850","article-title":"Ultrasonic assessment of the effects of self-assembling peptide scaffolds on preventing enamel demineralization","volume":"74","author":"Takahashi","year":"2016","journal-title":"Acta Odontol Scand"},{"key":"R11-20260121","doi-asserted-by":"crossref","first-page":"5629","DOI":"10.3390\/ijerph19095629","article-title":"Nano-Hydroxyapatite (nHAp) in the remineralization of early dental caries: A scoping review","volume":"19","author":"Anil","year":"2022","journal-title":"Int J Environ Res Public Health"},{"key":"R12-20260121","first-page":"705","article-title":"Effect of fluoride, casein phosphopeptide-amorphous calcium phosphate and Casein phosphopeptide-Amorphous calcium phosphate fluoride on enamel surface microhardness after microabrasion: An in vitro study","volume":"12","author":"Zenouz","year":"2015","journal-title":"J Dent (Tehran)"},{"key":"R13-20260121","doi-asserted-by":"crossref","first-page":"42","DOI":"10.4103\/0972-0707.62634","article-title":"Remineralization potential of fluoride and amorphous calcium phosphate-casein phospho peptide on enamel lesions: An in vitro comparative evaluation","volume":"13","author":"Lata","year":"2010","journal-title":"J Conserv Dent"}],"container-title":["Indian Journal of Dental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ijdr.ijdr_880_23","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:20:25Z","timestamp":1787836825000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ijdr.ijdr_880_23"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":13,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/ijdr.ijdr_880_23","relation":{},"ISSN":["0970-9290","1998-3603"],"issn-type":[{"value":"0970-9290","type":"print"},{"value":"1998-3603","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"2023-10-23","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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