{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T17:14:52Z","timestamp":1773076492525,"version":"3.50.1"},"reference-count":32,"publisher":"Scientific Scholar","content-domain":{"domain":["ijdvl.com"],"crossmark-restriction":true},"short-container-title":["IJDVL"],"abstract":"<jats:p>Nevoid acanthosis nigricans is a rare, benign form of acanthosis nigricans. Of the 24 cases documented in the literature, only two are exclusively localized to the umbilicus. We present four cases of nevoid acanthosis nigricans localized to the umbilicus; in patients less than 25 years of age, with no known co-morbidities, three of whom were females. Two of the cases received, with good response, treatment based on topical calcipotriol, a medication not previously reported to be used for this indication. Contrary to other types of acanthosis nigricans, the nevoid acanthosis nigricans is not associated with any syndrome, endocrinopathy, obesity, medication, or neoplasia and it can be confused with other pathologies such as epidermal nevus or dermatosis neglecta.<\/jats:p>","DOI":"10.4103\/ijdvl.ijdvl_1016_18","type":"journal-article","created":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T13:02:02Z","timestamp":1591016522000},"page":"660-665","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Nevoid acanthosis nigricans: Report of four cases localized to the umbilicus"],"prefix":"10.25259","volume":"87","author":[{"given":"Sonia E.","family":"Reyes-Meza","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Guevara-Guti\u00e9rrez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guadalupe","family":"Villanueva-Quintero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Socorro","family":"Hern\u00e1ndez-Arana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Tlacuilo-Parra","sequence":"additional","affiliation":[{"name":"Medical Research Division, UMAE Pediatric Hospital, CMNO, IMSS, Guadalajara, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10894","published-online":{"date-parts":[[2021,2,1]]},"reference":[{"key":"10.4103\/ijdvl.IJDVL_1016_18\/ref-1","doi-asserted-by":"publisher","first-page":"407","DOI":"10.2147\/CCID.S137527","article-title":"Current treatment options for acanthosis nigricans","volume":"11","author":"Patel","year":"2018","journal-title":"Clin Cosmet Investig Dermatol"},{"key":"10.4103\/ijdvl.IJDVL_1016_18\/ref-2","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1016\/j.clindermatol.2015.04.010","article-title":"Acanthosis nigricans: A fold (intertriginous) dermatosis","volume":"33","author":"Kutlubay","year":"2015","journal-title":"Clin Dermatol"},{"key":"10.4103\/ijdvl.IJDVL_1016_18\/ref-3","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1111\/j.1365-2133.1976.tb00847.x","article-title":"Unilateral epidermal naevus resembling acanthosis nigricans","volume":"95","author":"Curth","year":"1976","journal-title":"Br J Dermatol"},{"key":"10.4103\/ijdvl.IJDVL_1016_18\/ref-4","doi-asserted-by":"publisher","first-page":"95","DOI":"10.5021\/ad.2011.23.1.95","article-title":"Unilateral nevoid acanthosis nigricans with a submammary location","volume":"23","author":"Jeong","year":"2011","journal-title":"Ann Dermatol"},{"key":"10.4103\/ijdvl.IJDVL_1016_18\/ref-5","doi-asserted-by":"publisher","first-page":"337","DOI":"10.7241\/ourd.20153.90","article-title":"Nevoid acanthosis nigricans: A rare case with late onset","volume":"6","author":"Gupta","year":"2015","journal-title":"Our Dermatol Online"},{"key":"10.4103\/ijdvl.IJDVL_1016_18\/ref-6","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1111\/j.1346-8138.2006.00103.x","article-title":"Nevoid acanthosis nigricans localized to the umbilicus","volume":"33","author":"Kim","year":"2006","journal-title":"J Dermatol"},{"key":"10.4103\/ijdvl.IJDVL_1016_18\/ref-7","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.annder.2011.10.411","article-title":"Nevoid acanthosis nigricans or RAVEN (rounded and velvety epidermal nevus): Three cases","volume":"139","author":"Petit","year":"2012","journal-title":"Ann Dermatol Venereol"},{"key":"10.4103\/ijdvl.IJDVL_1016_18\/ref-8","doi-asserted-by":"publisher","first-page":"24","DOI":"10.5021\/ad.2005.17.1.24","article-title":"Nevoid acanthosis nigricans localized to the umbilicus: Successful treatment with topical tretinoin","volume":"17","author":"Lee","year":"2005","journal-title":"Ann Dermatol"},{"key":"10.4103\/ijdvl.IJDVL_1016_18\/ref-9","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1080\/00015550310007706","article-title":"A case of nevoid acanthosis nigricans","volume":"84","author":"Kim","year":"2004","journal-title":"Acta Derm Venereol"},{"key":"10.4103\/ijdvl.IJDVL_1016_18\/ref-10","doi-asserted-by":"publisher","first-page":"279","DOI":"10.4103\/0378-6323.41392","article-title":"Nevoid acanthosis nigricans","volume":"74","author":"Das","year":"2008","journal-title":"Indian J Dermatol Venereol Leprol"},{"key":"10.4103\/ijdvl.IJDVL_1016_18\/ref-11","doi-asserted-by":"publisher","first-page":"715","DOI":"10.4103\/0378-6323.72460","article-title":"Unilateral nevoid acanthosis nigricans and neurofibromatosis 1: An unusual association","volume":"76","author":"Krishnaram","year":"2010","journal-title":"Indian J Dermatol Venereol Leprol"},{"key":"10.4103\/ijdvl.IJDVL_1016_18\/ref-12","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1016\/j.jaad.2006.01.026","article-title":"The acanthosis nigricans form of epidermal nevus","volume":"55","author":"Ersoy-Evans","year":"2006","journal-title":"J Am Acad Dermatol"},{"key":"10.4103\/ijdvl.IJDVL_1016_18\/ref-13","doi-asserted-by":"publisher","first-page":"176","DOI":"10.4274\/tdd.2017","article-title":"Nevoid akantozis nigrikans","volume":"3","author":"Turan","year":"2014","journal-title":"Turk J Dermatol"},{"key":"10.4103\/ijdvl.IJDVL_1016_18\/ref-14","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1111\/j.1365-4362.1991.tb03911.x","article-title":"Unilateral nevoid acanthosis nigricans","volume":"30","author":"Krishnaram","year":"1991","journal-title":"Int J Dermatol"},{"key":"10.4103\/ijdvl.IJDVL_1016_18\/ref-15","doi-asserted-by":"crossref","first-page":"S102","DOI":"10.1016\/j.jaad.2007.03.017","article-title":"Nevoid acanthosis nigricans with subtle melanocyte hyperplasia","volume":"58","author":"Colegio","year":"2008","journal-title":"J Am Acad Dermatol"},{"key":"10.4103\/ijdvl.IJDVL_1016_18\/ref-16","first-page":"8","article-title":"Linear acanthosis nigricans","volume":"9","author":"Nath","year":"2013","journal-title":"Egypt Dermatol Online J"},{"key":"10.4103\/ijdvl.IJDVL_1016_18\/ref-17","doi-asserted-by":"crossref","first-page":"S40","DOI":"10.4103\/2229-5178.144529","article-title":"Unilateral nevoid acanthosis nigricans: Uncommon variant of a common disease","volume":"5","author":"Das","year":"2014","journal-title":"Indian Dermatol Online J"},{"key":"10.4103\/ijdvl.IJDVL_1016_18\/ref-18","first-page":"268","article-title":"RAVEN: forma particular de nevo epid\u00e9rmico, Primer caso argentino","volume":"20","author":"Cabrera","year":"2014","journal-title":"Dermatol Argent"},{"key":"10.4103\/ijdvl.IJDVL_1016_18\/ref-19","doi-asserted-by":"crossref","first-page":"bcr2014204611","DOI":"10.1136\/bcr-2014-204611","article-title":"Rounded and velvety epidermal naevus, report of a verrucous form in axillary location","volume":"2014","author":"Mestre","year":"2014","journal-title":"BMJ Case Rep"},{"key":"10.4103\/ijdvl.IJDVL_1016_18\/ref-20","doi-asserted-by":"crossref","first-page":"bcr2015210614","DOI":"10.1136\/bcr-2015-210614","article-title":"Unilateral nevoid acanthosis nigricans","volume":"2015","author":"Bansal","year":"2015","journal-title":"BMJ Case Rep"},{"key":"10.4103\/ijdvl.IJDVL_1016_18\/ref-21","doi-asserted-by":"crossref","first-page":"bcr2016216073","DOI":"10.1136\/bcr-2016-216073","article-title":"Unilateral nevoid acanthosis nigricans treated with CO2 laser","volume":"2016","author":"Campos","year":"2016","journal-title":"BMJ Case Rep"},{"key":"10.4103\/ijdvl.IJDVL_1016_18\/ref-22","doi-asserted-by":"publisher","first-page":"43","DOI":"10.5005\/jp-journals-10005-1232","article-title":"Congenital epidermal nevus","volume":"7","author":"Arora","year":"2014","journal-title":"Int J Clin Pediatr Dent"},{"key":"10.4103\/ijdvl.IJDVL_1016_18\/ref-23","doi-asserted-by":"publisher","first-page":"217","DOI":"10.2147\/CCID.S92051","article-title":"Confluent and reticulated papillomatosis: Diagnostic and treatment challenges","volume":"9","author":"Lim","year":"2016","journal-title":"Clin Cosmet Investig Dermatol"},{"key":"10.4103\/ijdvl.IJDVL_1016_18\/ref-24","first-page":"181","article-title":"Dowling-degos disease","volume":"51","author":"Georgescu","year":"2010","journal-title":"Rom J Morphol Embryol"},{"key":"10.4103\/ijdvl.IJDVL_1016_18\/ref-25","doi-asserted-by":"publisher","first-page":"152","DOI":"10.5021\/ad.2016.28.2.152","article-title":"Clinical and histopathological investigation of seborrheic keratosis","volume":"28","author":"Roh","year":"2016","journal-title":"Ann Dermatol"},{"key":"10.4103\/ijdvl.IJDVL_1016_18\/ref-26","doi-asserted-by":"publisher","first-page":"62","DOI":"10.4103\/0378-6323.74986","article-title":"Dermatitis neglecta","volume":"77","author":"Choudhary","year":"2011","journal-title":"Indian J Dermatol Venereol Leprol"},{"key":"10.4103\/ijdvl.IJDVL_1016_18\/ref-27","first-page":"176","article-title":"Clinical analysis of 48 cases of inverse psoriasis: A hospital-based study","volume":"15","author":"Wang","year":"2005","journal-title":"Eur J Dermatol"},{"key":"10.4103\/ijdvl.IJDVL_1016_18\/ref-28","doi-asserted-by":"publisher","first-page":"26","DOI":"10.5021\/ad.2015.27.1.26","article-title":"Histopathological findings are associated with the clinical types of psoriasis but not with the corresponding lesional psoriasis severity index","volume":"27","author":"Kim","year":"2015","journal-title":"Ann Dermatol"},{"key":"10.4103\/ijdvl.IJDVL_1016_18\/ref-29","doi-asserted-by":"publisher","first-page":"122","DOI":"10.3389\/fphys.2014.00122","article-title":"The future of Vitamin D analogs","volume":"5","author":"Leyssens","year":"2014","journal-title":"Front Physiol"},{"key":"10.4103\/ijdvl.IJDVL_1016_18\/ref-30","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1016\/0006-2952(88)90177-3","article-title":"Effects of a novel vitamin D analogue MC903 on cell proliferation and differentiation in vitro and on calcium metabolism in vivo","volume":"37","author":"Binderup","year":"1988","journal-title":"Biochem Pharmacol"},{"key":"10.4103\/ijdvl.IJDVL_1016_18\/ref-31","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1067\/mjd.2002.117848","article-title":"Nevoid hyperkeratosis of the nipple and areola: Treatment of two patients with topical calcipotriol","volume":"46","author":"Bayramg\u00fcrler","year":"2002","journal-title":"J Am Acad Dermatol"},{"key":"10.4103\/ijdvl.IJDVL_1016_18\/ref-32","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1016\/S0001-7310(08)74733-1","article-title":"Unilateral nevoid hyperkeratosis of the nipple and areola treated with topical calcitriol","volume":"99","author":"Guevara-Guti\u00e9rrez","year":"2008","journal-title":"Actas Dermosifiliogr"}],"container-title":["Indian Journal of Dermatology, Venereology and Leprology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ijdvl.com\/nevoid-acanthosis-nigricans-report-of-four-cases-localized-to-the-umbilicus\/","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ijdvl.com\/nevoid-acanthosis-nigricans-report-of-four-cases-localized-to-the-umbilicus\/","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,18]],"date-time":"2021-08-18T18:23:17Z","timestamp":1629310997000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ijdvl.com\/nevoid-acanthosis-nigricans-report-of-four-cases-localized-to-the-umbilicus\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,1]]},"references-count":32,"alternative-id":["10.4103\/ijdvl.IJDVL_1016_18"],"URL":"https:\/\/doi.org\/10.4103\/ijdvl.ijdvl_1016_18","relation":{},"ISSN":["0378-6323"],"issn-type":[{"value":"0378-6323","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,1]]},"article-number":"660"}}