{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T03:10:26Z","timestamp":1789096226260,"version":"build-2803163510"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Transsphenoidal surgery (TSS) is the primary treatment of choice for growth hormone (GH)-secreting pituitary adenomas. However, surgical cure rates vary. We aimed to investigate factors determining remission and the need for adjuvant therapy after TSS in patients with acromegaly managed at a tertiary care centre.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>In this retrospective single-centre study, data on patients who underwent TSS at a tertiary care centre were collected from 2010 to 2022. Multivariate regression models were used to identify predictors of endocrine remission according to the 2014 consensus criteria (random GH &lt;1 \u03bcg\/L and insulin-like growth factor 1 normalised for age) and of the requirement for adjuvant therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      This study included 169 patients (56% female, mean age 37.8 \u00b1 4.9 years), with a mean time from symptom onset to diagnosis of 4.9 \u00b1 3.9 years. Fifty-three (31.3%) achieved remission with a mean follow-up of 5.2 \u00b1 3.4 years. Adjuvant therapy was required in 78 patients, and redo surgery was performed in eight patients. Baseline GH levels were the only significant predictor of disease activity at the last follow-up. Baseline tumour size (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.003) and nadir GH levels (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.02) were the only independent factors associated with endocrine remission and the need for adjuvant therapy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Long-term remission in acromegaly following TSS is achieved in 31.3% of patients. Baseline tumour size and pretreatment nadir GH levels are the primary factors associated with achieving endocrine remission and the need for adjuvant therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijem.ijem_1001_25","type":"journal-article","created":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T17:01:50Z","timestamp":1788195710000},"page":"340-345","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Prevalence and Predictors of Remission in Patients with Acromegaly Undergoing Microscopic or Endoscopic Transsphenoidal Surgery: Long-Term Outcomes from a Tertiary Care Centre"],"prefix":"10.4103","volume":"30","author":[{"given":"Mintu M.","family":"Baruah","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Post Graduate Institute of Medical Education and Research, Chandigarh, 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