{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T03:10:26Z","timestamp":1789096226408,"version":"build-2803163510"},"reference-count":22,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>First-year growth response to biosynthetic growth hormone (GH) largely varies between populations. We aimed to predict first-year growth response to growth hormone replacement therapy (GHRT) in children with growth hormone deficiency (GHD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Growth response during the first year of GHRT was determined for both prepubertal and peripubertal children with congenital isolated GHD. The diagnosis of GHD was made using a standard work-up plan. Subjects with acquired causes of GHD were excluded. GHRT was started as per standard treatment guidelines. A predictive growth model based on these variables was derived from the analysis for the first-year growth response.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>A total of 107 children with congenital GHD were studied (70 prepubertal; 37 peripubertal). The age at initiation of GHRT was 11.36 \u00b1 3.83 years. In the prepubertal group, age at baseline and differences between mid-parental height (MPH; MPH-standard deviation score [SDS] and height-SDS) were significant predictors of first-year growth velocity response. The first-year height velocity was 11.12 \u00b1 3.62 cm. Prediction formula for prepubertal group is as follows: first-year growth velocity = 10.24 + 1.27*(difference between MPH-SDS and height-SDS) \u22120.27* Age. In peripubertal children with GHD, gender, mother\u2019s height, and the difference between MPH-SDS and height-SDS were important predictors of first-year growth velocity. The first-year height velocity was 8.85 \u00b1 2.84 cm. Prediction formula for the peripubertal group is as follows: 14.09 + 0.69*(difference between MPH-SDS and height-SDS) + 0.16*Mother height\u20132.51*gender.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>This model is an accurate and practicable tool to predict first-year growth response in GHD children in the Indian subcontinent.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijem.ijem_1005_25","type":"journal-article","created":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T17:01:50Z","timestamp":1788195710000},"page":"335-339","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Prediction of First-Year Growth Velocity Response to Growth Hormone Therapy in Patients with Growth Hormone Deficiency"],"prefix":"10.4103","volume":"30","author":[{"given":"Ravindranath K.","family":"Reddy","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolism, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manasvini","family":"Bhatt","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanshja","family":"Pandit","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aashima D.","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Maulana Azad Medical College, New Delhi, Delhi, 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