{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T13:03:38Z","timestamp":1791291818630,"version":"4.1.0"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Adiponectin and leptin play a major role in metabolic homeostasis. Adiponectin to Leptin ratio can be used as an indicator of insulin resistance and a marker of polycystic ovarian syndrome (PCOS). The study was planned to compare serum adiponectin, leptin, and adiponectin to leptin ratio in age and BMI matched women with and without PCOS and to find out the association of adiponectin to leptin ratio with Insulin resistance in these women.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>It was a cross-sectional study done in the Gynecology outpatient clinic in a tertiary care center. A total of 120 women, 60 with PCOS and 60 age and BMI matched women without PCOS, who presented in the clinic after the index cases were enrolled and tested for serum adiponectin, leptin, and insulin sensitivity. The main outcome measures were serum levels of adiponectin, leptin, adiponectin to leptin ratio, oral glucose tolerance test, serum insulin and HOMA-IR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      PCOS women had lower serum Adiponectin, higher serum Leptin level and lower Adiponectin to Leptin ratio compared to non PCOS women, 2.15 \u00b1 3.07 ng\/ml vs 10.7 \u00b1 27.91 ng\/ml,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.0001; 24.25 \u00b1 16.5 ng\/ml vs 13.89 \u00b1 11.19 ng\/ml,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.0003 and 0.15 \u00b1 0.24 vs 3.03 \u00b1 15.04,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.0001, respectively. Plasma glucose 2 hours after 75 gm glucose and serum Insulin was significantly increased in PCOS women (108.78 \u00b1 10.22 mg\/dl vs 100.18 \u00b1 4.89 mg\/dl,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.001 and 5.7 \u00b1 9.53 mU\/ml vs 3.02 \u00b1 5.34 mU\/ml,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.02, respectively). The mean values of fasting plasma glucose and HOMA-IR were comparable in both groups,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.145,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.719, respectively. There was no significant association of A\/L Ratio with BMI, plasma glucose 2 hours after 75 gm glucose, serum Insulin and HOMA-IR, in these women, r = -0.074,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.5754; r = -0.203,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.12; r = -0.018,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.8915; and r = -0.041,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.757, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Adiponectin to leptin ratio is significantly reduced in women with PCOS but has no association with insulin resistance.<\/jats:p>\n                  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