{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T20:15:19Z","timestamp":1793304919715,"version":"4.5.0"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Recent evidence reveals that type 1 diabetes mellitus (T1DM) impairs muscle function (MF) in adolescents. However, despite its importance in physical well-being, data on dynamic MF in Indian children and adolescents (C and Y) with T1DM are scarce. We assessed MF using Jumping Mechanography (JM, a measurement method for motion analysis and assessment of muscle power and force). (1) To assess dynamic MF by JM in C and Y with T1DM as compared to healthy controls (2) To determine predictors of MF in children with T1DM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      A cross-sectional observational study on 266 children (133 \u2013 T1DM duration &gt;1 year with no known comorbidities + 133 age and gender-matched healthy controls) aged 6\u201319 years. Anthropometry, body composition, and MF (maximum relative power Pmax\/mass, maximum relative force Fmax\/BW by JM) were recorded. The lean mass index (LMI) was calculated as lean mass (kg)\/height (m\n                      <jats:sup>2<\/jats:sup>\n                      ). HbA1c was assessed in T1DM. Independent sample\n                      <jats:italic toggle=\"yes\">t<\/jats:italic>\n                      -test and linear regression were performed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      MF parameters (Pmax\/mass 33.5 \u00b1 7.2 vs 38.0 \u00b1 8.6 W\/kg and Fmax\/BW 10.5 \u00b1 2.9 vs 11.4 \u00b1 4.1 N\/kg,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.05) were significantly lower in T1DM group vs controls. Positive association of body mass index and LMI with both MF parameters and negative association of insulin requirement and HbA1c with Fmax was observed in T1DM. Predictors of MF identified were MMI (Pmax\/mass:b = 1.6,95%CI = 0.6\u20132.6; Fmax\/BW:b =2.0,95%CI = 1.6\u20132.4) and HbA1c (Pmax\/mass:b = \u22122.1,95%CI = \u22124.5\u2013\u22120.5; Fmax\/BW:b = \u22121.1,95%CI = \u22122.0\u2013\u22120.2) (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>C and Y with T1DM exhibits compromised muscle function. Poor glycaemic control increases the risk of having decreased MF, irrespective of diabetes duration and may contribute to sarcopenia in adulthood.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijem.ijem_140_23","type":"journal-article","created":{"date-parts":[[2024,4,30]],"date-time":"2024-04-30T03:00:59Z","timestamp":1714446059000},"page":"201-207","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":4,"title":["Dynamic Muscle Function Parameters in Indian Children and Adolescents with Type 1 Diabetes Mellitus: A Case-Control Study"],"prefix":"10.4103","volume":"28","author":[{"given":"Sonal V.","family":"Kasture","sequence":"first","affiliation":[{"name":"Department of Growth and Paediatric Endocrinology, Hirabai Cowasji Jehangir Medical Research Institute, Jehangir Hospital, 32, Sassoon Road, Pune, Maharashtra, India"},{"name":"School of Health Sciences, Savitribai Phule Pune University, Pune, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shruti A.","family":"Mondkar","sequence":"additional","affiliation":[{"name":"Department of Growth and Paediatric Endocrinology, Hirabai Cowasji Jehangir Medical Research Institute, Jehangir Hospital, 32, Sassoon Road, Pune, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anuradha V.","family":"Khadilkar","sequence":"additional","affiliation":[{"name":"Department of Growth and Paediatric Endocrinology, Hirabai Cowasji Jehangir Medical Research Institute, Jehangir Hospital, 32, Sassoon Road, Pune, Maharashtra, India"},{"name":"School of Health Sciences, Savitribai Phule Pune University, Pune, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ketan","family":"Gondhalekar","sequence":"additional","affiliation":[{"name":"Department of Growth and Paediatric Endocrinology, Hirabai Cowasji Jehangir Medical Research Institute, Jehangir Hospital, 32, 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