{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T17:58:49Z","timestamp":1789840729075,"version":"4.0.1"},"reference-count":17,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,5]]},"abstract":"\n Objective:<\/jats:title>\n New-onset diabetes after transplantation (NODAT) develops frequently after renal transplant. The study aims at the prevalence of NODAT, predictors for developing it and therapeutic glycemic responses in NODAT.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n \n Consecutive renal transplant recipients excluding Diabetic Kidney Disease (DKD) or pretransplant diabetes were evaluated. Forty-three out of 250 persons were found to have NODAT. Ninety age-matched transplant recipients from the rest were recruited as control. Fasting blood sugar (FBS), HbA1c, lipid profile, and trough tacrolimus level (T\n 0<\/jats:sub>\n ) were examined in all. HOMA IR C-peptide and HOMA-beta C-peptide were calculated.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Prevalence of NODAT in renal transplant recipients was 17.2% (43\/250). Twenty-four (55.8%) developed early NODAT (<1 year) and 19 (44.2%) developed late NODAT (>1 year). Significantly higher pretransplant body mass index (BMI) (kg\/m\n 2<\/jats:sup>\n ) (\n P<\/jats:italic>\n < 0.001), waist circumference (WC) (cm) (\n P<\/jats:italic>\n < 0.001), pretransplant cholesterol (mg%) (\n P<\/jats:italic>\n = 0.04), triglyceride (mg%) (\n P<\/jats:italic>\n < 0.001), and FBS (mg%) (\n P<\/jats:italic>\n < 0.001) were found in NODAT compared with non-NODAT. Trough tacrolimus (ng\/mL) was found to be higher in NODAT (10.2 vs. 5.37,\n P<\/jats:italic>\n < 0.001). Though HOMA IR was not found to be different between groups, HOMA-beta C-peptide was low in NODAT compared with non-NODAT (\n P<\/jats:italic>\n = 0.03). Predictors of NODAT were WC [odds ratio (OR) = 01.15] and trough tacrolimus level (OR = 1.316). Best cut-off of WC for predicting NODAT was 87.5 cm for male and 83.5 cm for female. Best cut-off of T\n 0<\/jats:sub>\n was 8.5 ng\/mL. In NODAT, 9.3% were treated by lifestyle modification, 67.4% by oral hypoglycemic agents, 11.6% by insulin, and 11.6% by combined insulin and oral antidiabetic agents with HbA1c <7%.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n NODAT in renal transplant recipients is more common in those with higher pretransplant BMI, WC, pretransplant total cholesterol, triglyceride, and FBS. Beta-cell secretory defect is more relevant as etiological factor rather than insulin resistance. Higher WC and trough tacrolimus level above 8.5 ng\/mL may be important factors for predicting NODAT.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/ijem.ijem_178_19","type":"journal-article","created":{"date-parts":[[2019,7,29]],"date-time":"2019-07-29T06:58:27Z","timestamp":1564383507000},"page":"273-277","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":22,"title":["Prevalence and Predictors of \u201cNew-onset Diabetes after Transplantation\u201d (NODAT) in Renal Transplant Recipients: An Observational Study"],"prefix":"10.4103","volume":"23","author":[{"given":"Partha Sarathi","family":"Choudhury","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Medical College, Kolkata, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pradip","family":"Mukhopadhyay","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, IPGME&R, Kolkata, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arpita","family":"Roychowdhary","sequence":"additional","affiliation":[{"name":"Department of Nephrology, IPGME&R, Kolkata, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subhankar","family":"Chowdhury","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, IPGME&R, Kolkata, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sujoy","family":"Ghosh","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, IPGME&R, Kolkata, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20260327","doi-asserted-by":"crossref","first-page":"SS3","DOI":"10.1097\/01.TP.0000069952.49242.3E","article-title":"New-onset diabetes after transplantation: 2003 International Consensus Guidelines","volume":"75","author":"Davidson","year":"2003","journal-title":"Transplantation"},{"key":"R2-20260327","doi-asserted-by":"crossref","first-page":"871","DOI":"10.4103\/ijem.IJEM_309_17","article-title":"The prevalence of new onset diabetes mellitus after renal transplantation in patients with immediate posttransplant hyperglycemia in a tertiary care centre","volume":"21","author":"Memon","year":"2017","journal-title":"Indian J Endocr Metab"},{"key":"R3-20260327","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1097\/00007890-200111270-00014","article-title":"Posttransplantation diabetes mellitus in FK-506-treated renal transplant recipients: Analysis of incidence and risk factors","volume":"72","author":"Maes","year":"2001","journal-title":"Transplantation"},{"key":"R4-20260327","doi-asserted-by":"crossref","first-page":"374","DOI":"10.2215\/CJN.03791106","article-title":"Therapeutic monitoring of calcineurin inhibitors for the nephrologist","volume":"2","author":"Schiff","year":"2007","journal-title":"Clin J Am Soc Nephrol"},{"key":"R5-20260327","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/S0041-1345(98)01633-9","article-title":"Low systemic exposure to tacrolimus correlates with acute rejection","volume":"31","author":"Undre","year":"1999","journal-title":"Transplant Proc"},{"key":"R6-20260327","first-page":"228","article-title":"New onset of diabetes mellitus in Indian renal transplant recipient \u2013 A retrospective study","volume":"7","author":"Patel","year":"2015","journal-title":"Int J Pharm Pharm Sci"},{"key":"R7-20260327","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1034\/j.1600-6143.2003.00010.x","article-title":"Diabetes mellitus after kidney transplantation in the United States","volume":"3","author":"Kasiske","year":"2003","journal-title":"Am J Transplant"},{"key":"R8-20260327","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1034\/j.1600-6143.2003.00082.x","article-title":"Incidence and cost of new onset diabetes mellitus among U.S. wait listed and transplanted renal allograft recipients","volume":"3","author":"Woodward","year":"2003","journal-title":"Am J Transplant"},{"key":"R9-20260327","first-page":"8969","article-title":"New onset diabetes after renal transplantation (NODAT): Prevalence, risk factors and treatment","volume":"4","author":"Lakshminaryana","year":"2016","journal-title":"JMSCR"},{"issue":"Suppl 5A","key":"R10-20260327","doi-asserted-by":"crossref","first-page":"8S","DOI":"10.1016\/S0041-1345(01)02229-1","article-title":"Risk factors and incidence of posttransplant diabetes mellitus","volume":"33","author":"Reis\u00e6ter","year":"2001","journal-title":"Trans Proc"},{"key":"R11-20260327","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1097\/00007890-199102000-00014","article-title":"Diabetes mellitus after renal transplantation in the cyclosporine era: An analysis of risk factors","volume":"51","author":"Sumrani","year":"1991","journal-title":"Transplantation"},{"key":"R12-20260327","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1016\/j.transproceed.2008.05.045","article-title":"Analysis of post transplant diabetes mellitus prevalence in a population of kidney transplant recipients","volume":"40","author":"Bonato","year":"2008","journal-title":"Transplant Proc"},{"key":"R13-20260327","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.nefro.2016.11.022","article-title":"The incidence of new Onset diabetes after transplantation and related factors: Single centre experience","volume":"37","author":"Sinangil","year":"2017","journal-title":"Nefrologia"},{"key":"R14-20260327","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1093\/ndt\/gfm762","article-title":"The combined effect of pre-transplant triglyceride levels and the type of calcineurin inhibitor in predicting the risk of new onset diabetes after renal transplantation","volume":"23","author":"Porrini","year":"2008","journal-title":"Nephrol Dial Transplant"},{"key":"R15-20260327","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1093\/ndt\/16.4.829","article-title":"Tapering off prednisolone and cyclosporin the first year after renal transplantation: The effect on glucose tolerance","volume":"16","author":"Hjelmesaeth","year":"2001","journal-title":"Nephrol Dial Transplant"},{"key":"R16-20260327","doi-asserted-by":"crossref","first-page":"40050","DOI":"10.1074\/jbc.M110.154955","article-title":"Calcineurin signaling regulates human islet {beta}-cell survival","volume":"17","author":"Soleimanpour","year":"2010","journal-title":"J Biol Chem"},{"key":"R17-20260327","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1097\/00007890-199506000-00018","article-title":"Transcriptional inhibition of insulin by FK506 and possible involvement of FK506 binding protein-12 in pancreatic beta-cell","volume":"59","author":"Tamura","year":"1995","journal-title":"Transplantation"}],"container-title":["Indian Journal of Endocrinology and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/02223308-201923030-00002","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:47:10Z","timestamp":1787068030000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/02223308-201923030-00002"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5]]},"references-count":17,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019]]}},"URL":"https:\/\/doi.org\/10.4103\/ijem.ijem_178_19","relation":{},"ISSN":["2230-8210","2230-9500"],"issn-type":[{"value":"2230-8210","type":"print"},{"value":"2230-9500","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5]]}}}