{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T17:25:08Z","timestamp":1787765108357,"version":"build-2784847793"},"reference-count":32,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Thyrotoxicosis is not uncommon after immunization. It is known as \u2018autoimmune\/autoinflammatory syndrome by adjuvants (ASIA syndrome)\u2019 and is caused by immunological reaction to adjuvants. However, there is insufficient information on thyrotoxicosis after COVID-19 vaccination in the Indian subcontinent.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims\/Objectives:<\/jats:title>\n                    <jats:p>To investigate the spectrum of thyrotoxicosis after COVID-19 immunization.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Settings and Design:<\/jats:title>\n                    <jats:p>A single-centre retrospective study was conducted at a tertiary care academic institute in India.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>We studied the clinical symptoms, biochemical markers, imaging characteristics and treatment of every patient who was diagnosed with thyrotoxicosis within 60 days of receiving the COVID-19 vaccine.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Following COVID-19 vaccination, we diagnosed ten people (mean age 39.9 years, range 22-63 years) with thyrotoxicosis [Graves\u2019 disease (GD,\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      -6) and subacute thyroiditis (SAT,\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      -4)]. The typical duration for symptoms to appear was 2 to 60 days. The majority of patients (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      -9) received the COVISHIELD\u2122 vaccine, whereas only one received the COVAXIN\n                      <jats:sup>\u00ae<\/jats:sup>\n                      vaccine. After vaccination, two patients with GD developed mildly severe Graves\u2019 orbitopathy, with symptoms emerging two days and sixty days later, respectively. Anti-thyroid drugs (methimazole or carbimazole) were required for all GD patients. All SAT patients were treated conservatively with nonsteroidal anti-inflammatory medications and had positive outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>\n                      SAT, GD and GO may occur as a manifestation of ASIA syndrome, following immunization with COVISHIELD\u2122 and COVAXIN\n                      <jats:sup>\u00ae<\/jats:sup>\n                      . Despite the obvious benefits of the COVID-19 vaccine, clinicians should be aware of any potential autoimmune and inflammatory thyroid problems.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijem.ijem_202_23","type":"journal-article","created":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T05:01:10Z","timestamp":1705035670000},"page":"524-529","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Post-COVID-19 Vaccination and Thyrotoxicosis (ASIA Syndrome): Single-Centre Experience from India with Review of Literature"],"prefix":"10.4103","volume":"27","author":[{"given":"Vaibhav","family":"Singhal","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, 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