{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:32:10Z","timestamp":1791232330054,"version":"4.1.0"},"reference-count":43,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>The relationship between thyroid metabolism and coronavirus disease 2019 (COVID-19) inflammation has been extensively investigated. This meta-analysis aimed to evaluate the prognostic properties of unspecified thyroid disorders, hypothyroidism and hyperthyroidism for predicting poor COVID-19 outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We conducted systematic literature searching through multiple databases\u2013PubMed, EBSCO and CENTRAL up until 27 September 2021. The main exposure was unspecified thyroid disorders, hypothyroidism or hypothyroidism on-admission status. The outcome of interest was the COVID-19 composite poor outcome that comprises severity, mortality, ICU admission and hospitalisation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      There were 24517 patients from 20 studies. Meta-analysis showed that thyroid disorder, regardless of its type, was associated with COVID-19 poor outcome (OR 2.92 (95% CI 2.09 \u2013 4.08),\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001;\n                      <jats:italic toggle=\"yes\">I2<\/jats:italic>\n                      = 71%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001). Unspecified thyroid disorder has a sensitivity of 0.17 (0.08\u20130.33), specificity of 0.94 (0.88\u20130.97) and Area Under Curve (AUC) of 0.66. Hypothyroidism has a sensitivity of 0.24 (0.12\u20130.42), specificity of 0.92 (0.87\u20130.96) and AUC of 0.77. Hyperthyroidism has a sensitivity of 0.05 (0.02\u20130.11), specificity of 0.98 (0.88\u20131.00) and AUC of 0.36. In this pooled analysis, the posttest probability of unspecified thyroid disease, hypothyroidism and hyperthyroidism were 42%, 27% and 8% for poor outcomes, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Thyroid disorders are associated with poor COVID-19 prognosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijem.ijem_20_22","type":"journal-article","created":{"date-parts":[[2023,2,3]],"date-time":"2023-02-03T08:26:02Z","timestamp":1675412762000},"page":"510-517","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["The Prognostic Properties of Thyroid Disorders, Hypothyroidism, and Hyperthyroidism in Predicting COVID-19 Poor Outcomes: A Systematic Review and Diagnostic Meta-analysis"],"prefix":"10.4103","volume":"26","author":[{"given":"Hikmat","family":"Permana","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine, Universitas Padjadjaran \u2013 Dr. Hasan Sadikin Hospital, Bandung, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erwin Affandi","family":"Soeriadi","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Faculty of Medicine, Universitas Padjadjaran \u2013 Dr. Hasan Sadikin Hospital, Bandung, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fachreza Aryo","family":"Damara","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Universitas Padjadjaran \u2013 Dr. Hasan Sadikin Hospital, Bandung, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nanny Natalia Mulyani","family":"Soetedjo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of 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