{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T21:56:31Z","timestamp":1791410191393,"version":"4.3.3"},"reference-count":31,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,9]]},"abstract":"Abstract<\/jats:title>\n \n Background:<\/jats:title>\n Non-genetic factors like microbial dysbiosis may be contributing to the increasing incidence\/progression of type 1 diabetes mellitus (T1DM).<\/jats:p>\n <\/jats:sec>\n \n Objectives:<\/jats:title>\n To analyse the gut microbiota profile in Indian children with T1DM and its effect on glycaemic control.<\/jats:p>\n <\/jats:sec>\n \n Methodology:<\/jats:title>\n Faecal samples of 29 children with T1DM were collected and faecal microbial DNA was extracted and subjected to 16S rRNA (ribosomal RNA) sequencing and further analysis.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n The dominant phyla in children with T1DM were Firmicutes and Bacteroidetes. Butyrate-producing bacteria\n Blautia<\/jats:italic>\n and\n Ruminococcus<\/jats:italic>\n showed a significant negative correlation with the glycosylated haemoglobin (HbA1C) levels (\n p<\/jats:italic>\n < 0.05).\n Coprococcus<\/jats:italic>\n and\n Propionibacterium<\/jats:italic>\n were important negative predictors of glycaemic control (\n p<\/jats:italic>\n < 0.05).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n \n Our study suggests that Indian children with T1DM have a distinct gut microbiome taxonomic composition and that short-chain fatty acid-producing bacteria like\n Ruminococcus<\/jats:italic>\n and\n Blautia<\/jats:italic>\n (butyrate-producing) may play an important role in the glycaemic control of subjects with T1DM.\n <\/jats:p>\n 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