{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T18:07:46Z","timestamp":1793210866860,"version":"4.5.0"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>In this study, it was aimed to examine the clinical and laboratory findings that can be used to predict central precocious puberty (CPP) in cases whose breast development started before the age of 8.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>The chronological age, anthropometric measurements, bone age (BA), hormone test results and pelvic ultrasonography findings of the cases were recorded. Those with a peak luteinizing hormone (LH) level of \u22655 IU\/L in the gonadotropin-releasing hormone (GnRH) stimulation test were classified as CPP and those with a peak LH level of &lt;5 IU\/L were classified as prepubertal cases. A receiver operating characteristic (ROC) analysis was performed to determine the diagnostic accuracy of laboratory variables.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Findings:<\/jats:title>\n                    <jats:p>A total of 297 female cases were included in the study. The age at the time of admission, height-standard deviation score (SDS), BA, the long axis of the uterus and the volumes of the right and left ovaries of the cases diagnosed with CPP were found to be significantly higher than those of the prepubertal group. The cut-off value providing the best sensitivity (99%) and specificity (99%) for the peak LH was found to be 4.55; the cut-off value providing the best sensitivity (94%) and specificity (85%) for the peak LH\/follicle-stimulating hormone (FSH) ratio was found to be 0.32 and the cut-off value providing the best sensitivity (47%) and specificity (93%) for the basal LH was found to be 0.13.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>We believe that in female cases with early breast development, a peak LH level of \u22654.55 may possibly indicate CPP and a basal LH level of &lt;0.13 can significantly rule out CPP.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijem.ijem_245_22","type":"journal-article","created":{"date-parts":[[2023,6,26]],"date-time":"2023-06-26T02:02:39Z","timestamp":1687744959000},"page":"237-241","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":4,"title":["Evaluation of Clinical and Laboratory Findings in the Differential Diagnosis of Central Precocious Puberty and Premature Thelarche"],"prefix":"10.4103","volume":"27","author":[{"given":"Asl\u0131","family":"Be\u015fta\u015f","sequence":"first","affiliation":[{"name":"Department of Pediatric Endocrinology, Faculty of Medicine, Dicle University, Diyarbak\u0131r, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edip","family":"Unal","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology, Faculty of Medicine, Dicle University, Diyarbak\u0131r, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amine","family":"Aktar Karakaya","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology, Faculty of Medicine, Dicle University, Diyarbak\u0131r, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meliha","family":"Demiral","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology, Gazi Ya\u015fargil Training and Research Hospital, Diyarbak\u0131r, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuf K.","family":"Haspolat","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology, Faculty of Medicine, Dicle University, Diyarbak\u0131r, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,6,26]]},"reference":[{"key":"R1-20240828","first-page":"111","article-title":"Neurobiological mechanisms of the onset of puberty in primates","volume":"22","author":"Terasawa","year":"2001","journal-title":"Endocr Rev"},{"key":"R2-20240828","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1046\/j.0300-0664.2001.01490.x","article-title":"Management and outcome of central precocious puberty","volume":"56","author":"Partsch","year":"2002","journal-title":"Clin Endocrinol"},{"issue":"(Suppl 1)","key":"R3-20240828","first-page":"709","article-title":"Diagnosis of central precocious puberty:Endocrine assessment","volume":"13","author":"Iughetti","year":"2000","journal-title":"J Pediatr Endocrinol Metab"},{"key":"R4-20240828","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/S0889-8529(05)70108-0","article-title":"Central precocious puberty. An overview of diagnosis, treatment, and outcome","volume":"28","author":"Lee","year":"1999","journal-title":"Endocrinol Metab Clin North Am"},{"key":"R5-20240828","doi-asserted-by":"crossref","first-page":"e932","DOI":"10.1542\/peds.2008-2491","article-title":"Recent decline in age at breast development:The Copenhagen puberty study","volume":"123","author":"Aksglaede","year":"2009","journal-title":"Pediatrics"},{"key":"R6-20240828","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1111\/j.1365-2265.1995.tb02693.x","article-title":"Precocious puberty","volume":"42","author":"Brook","year":"1995","journal-title":"Clin Endocrinol (Oxf)"},{"key":"R7-20240828","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0022-3476(95)70255-5","article-title":"Spontaneous serum gonadotropin concentrations in the evaluation of precocious puberty","volume":"127","author":"Neely","year":"1995","journal-title":"J Pediatr"},{"key":"R8-20240828","doi-asserted-by":"crossref","first-page":"E30","DOI":"10.1542\/peds.109.2.e30","article-title":"Serum luteinizing hormone rises within minutes after depot leuprolide injection:Implications for monitoring therapy","volume":"109","author":"Bhatia","year":"2002","journal-title":"Pediatrics"},{"key":"R9-20240828","doi-asserted-by":"crossref","first-page":"e1059","DOI":"10.1542\/peds.2008-1180","article-title":"Adequacy of a single unstimulated luteinizing hormone level to diagnose central precocious puberty in girls","volume":"123","author":"Houk","year":"2009","journal-title":"Pediatrics"},{"key":"R10-20240828","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1055\/s-0032-1321905","article-title":"Utility of basal luteinizing hormone levels for detecting central precocious puberty in girls","volume":"44","author":"Lee","year":"2012","journal-title":"Horm Metab Res"},{"key":"R11-20240828","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1542\/peds.97.4.517","article-title":"A single-sample, subcutaneous gonadotropin-releasing hormone test for central precocious puberty","volume":"97","author":"Eckert","year":"1996","journal-title":"Pediatrics"},{"key":"R12-20240828","doi-asserted-by":"crossref","first-page":"196","DOI":"10.6065\/apem.2013.18.4.196","article-title":"Basal luteinizing hormone and follicular stimulating hormone:Is it sufficient for the diagnosis of precocious puberty in girls?","volume":"18","author":"Lee","year":"2013","journal-title":"Ann Pediatr Endocrinol Metab"},{"key":"R13-20240828","doi-asserted-by":"crossref","first-page":"27","DOI":"10.6065\/apem.2019.24.1.27","article-title":"Morning basal luteinizing hormone, a good screening tool for diagnosing central precocious puberty","volume":"24","author":"Lee","year":"2019","journal-title":"Ann Pediatr Endocrinol Metab"},{"key":"R14-20240828","doi-asserted-by":"crossref","first-page":"280","DOI":"10.4274\/jcrpe.2183","article-title":"Reference values for weight, height, head circumference, and body mass index in Turkish children","volume":"7","author":"Neyzi","year":"2015","journal-title":"J Clin Res Pediatr Endocrinol"},{"key":"R15-20240828","doi-asserted-by":"crossref","first-page":"182","DOI":"10.4274\/jcrpe.4526","article-title":"A comprehensive online calculator for pediatric endocrinologists:\u00c7EDD \u00c7\u00f6z\u00fcm\/TPEDS metrics","volume":"9","author":"Demir","year":"2017","journal-title":"J Clin Res Pediatr Endocrinol"},{"key":"R16-20240828","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1136\/adc.44.235.291","article-title":"Variations in pattern of pubertal changes in girls","volume":"44","author":"Marshall","year":"1969","journal-title":"Arch Dis Child"},{"key":"R17-20240828","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0009-9260(86)80376-2","article-title":"Assessment of bone age:A comparison of the Greulich and Pyle, and the Tanner and Whitehouse methods","volume":"37","author":"Milner","year":"1986","journal-title":"Clin Radiol"},{"key":"R18-20240828","first-page":"415","article-title":"Adult height in girls with idiopathic true precocious puberty","volume":"79","author":"Brauner","year":"1994","journal-title":"J Clin Endocrinol Metab"},{"key":"R19-20240828","doi-asserted-by":"crossref","first-page":"194","DOI":"10.3346\/jkms.2012.27.2.194","article-title":"Factors to predict positive results of gonadotropin releasing hormone stimulation test in girls with suspected precocious puberty","volume":"27","author":"Nam","year":"2012","journal-title":"J Korean Med Sci"},{"key":"R20-20240828","first-page":"131","article-title":"Adequacy of basal luteinizing hormone levels in the diagnosis of central precocious puberty","volume":"55","author":"Vurall\u0131","year":"2020","journal-title":"Turk Pediatri Ars"},{"key":"R21-20240828","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1530\/eje.1.02151","article-title":"Ultrasonographic and clinical parameters for early differentiation between precocious puberty and premature thelarche","volume":"154","author":"de Vries","year":"2006","journal-title":"Eur J Endocrinol"},{"key":"R22-20240828","doi-asserted-by":"crossref","first-page":"164","DOI":"10.6065\/apem.2019.24.3.164","article-title":"Basal serum luteinizing hormone value as the screening biomarker in female central precocious puberty","volume":"24","author":"Heo","year":"2019","journal-title":"Ann Pediatr Endocrinol Metab"},{"key":"R23-20240828","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1590\/S0041-87812002000200001","article-title":"Premature thelarche:Identification of clinical and laboratory data for the diagnosis of precocious puberty","volume":"57","author":"Della Manna","year":"2002","journal-title":"Rev Hosp Clin"},{"key":"R24-20240828","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1210\/jc.2006-1569","article-title":"Assessment of basal and gonadotropin-releasing hormone-stimulated gonadotropins by immunochemiluminometric and immunofluorometric assays in normal children","volume":"92","author":"Resende","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"R25-20240828","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/S0022-3476(95)70254-7","article-title":"Normal ranges for immunochemiluminometric gonadotropin assays","volume":"127","author":"Neely","year":"1995","journal-title":"J Pediatr"},{"key":"R26-20240828","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1530\/EJE-11-0720","article-title":"The utility of basal serum LH in prediction of central precocious puberty in girls","volume":"166","author":"Pasternak","year":"2012","journal-title":"Eur J Endocrinol"},{"key":"R27-20240828","doi-asserted-by":"crossref","first-page":"202","DOI":"10.6065\/apem.2013.18.4.202","article-title":"Factors that predict a positive response on gonadotropin-releasing hormone stimulation test for diagnosing central precocious puberty in girls","volume":"18","author":"Suh","year":"2013","journal-title":"Ann Pediatr Endocrinol Metab"},{"key":"R28-20240828","doi-asserted-by":"crossref","first-page":"20","DOI":"10.5152\/tpa.2015.2281","article-title":"Clinical and laboratory findings in the differential diagnosis of central precocious puberty and premature thelarche","volume":"50","author":"\u00c7atl\u0131","year":"2015","journal-title":"Turk Pediatri Ars"},{"key":"R29-20240828","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1210\/jcem-71-5-1251","article-title":"Gonadotropin secretory dynamics during puberty in normal girls and boys","volume":"71","author":"Oerter","year":"1990","journal-title":"J Clin Endocrinol Metab"}],"container-title":["Indian Journal of Endocrinology and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ijem.ijem_245_22","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:13:42Z","timestamp":1787760822000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ijem.ijem_245_22"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5]]},"references-count":29,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.4103\/ijem.ijem_245_22","relation":{},"ISSN":["2230-8210","2230-9500"],"issn-type":[{"value":"2230-8210","type":"print"},{"value":"2230-9500","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5]]},"assertion":[{"value":"2022-06-20","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-26","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}