{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T13:18:43Z","timestamp":1787750323642,"version":"build-2784847793"},"reference-count":56,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Thyroid dysfunction (TD) and cardiovascular disease (CVD) commonly coexist in older adults, where age-related vascular, mitochondrial, and autonomic changes heighten sensitivity to even mild hormonal imbalance. Thyroid hormones (THs) regulate cardiac and vascular function through genomic and non-genomic pathways, but aging alters receptor sensitivity, deiodinase (\n                    <jats:italic toggle=\"yes\">DIO<\/jats:italic>\n                    ) activity, and epigenetic control, resulting in tissue-specific TH insufficiency despite normal serum levels. Subclinical hypothyroidism (SCH) and low-T3 syndrome are especially prevalent in older adults and are linked to higher risks of heart failure (HF), atherosclerosis, atrial fibrillation, and mortality. Emerging data underscore the role of epigenetic regulators and the gut\u2013thyroid\u2013heart axis in modulating CV responses to TH imbalance. Clinically, routine thyroid function assessment is crucial in CVD, with management tailored to age-related risks. Tissue-selective TH based therapies represent a promising frontier for precision cardioprotection.\n                  <\/jats:p>","DOI":"10.4103\/ijem.ijem_24_26","type":"journal-article","created":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T14:01:55Z","timestamp":1782482515000},"page":"204-210","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Revisiting the Thyroid\u2013Heart Axis: Unravelling the Interplay of Hormones, Epigenomes and Precision Cardioprotection"],"prefix":"10.4103","volume":"30","author":[{"given":"Naima","family":"Parveen","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Diabetes Care, Harmony\u2013Dr Sachin\u2019s 360 Degree Diabetes Care Centre, Bhopal, Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachin","family":"Chittawar","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Diabetes 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