{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:36:27Z","timestamp":1787841387614,"version":"build-2784847793"},"reference-count":69,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Obesity, dyslipidaemia and insulin resistance are associated with hypopituitarism. The association between these conditions and Sheehan\u2019s syndrome (SS) caused by post-partum pituitary gland necrosis is poorly understood. This study aimed to assess cardiovascular risk surrogate markers in SS patients, and we compared clinical, biochemical and radiological testing with healthy controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>In this cross-sectional study, we studied 45 patients with SS on standard replacement therapy and compared them with healthy controls. All subjects underwent anthropometric, inflammatory marker and hormonal measurement (adrenocorticotropic hormone (ACTH), stimulated cortisol, insulin-like growth factor-1 (IGF-1), thyroxine (T4), follicle-stimulating hormone (FSH), luteinising hormone (LH), oestradiol (E2), prolactin (Prl), insulin, interleukin-6 (IL-6) and high-sensitivity C-reactive protein (hs-CRP)). Carotid intima-media thickness (CIMT), flow-mediated dilation (FMD) and echocardiography were also performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The mean age and body mass index (BMI) of SS patients were 48.1 \u00b1 10.0 years and 24.3 \u00b1 4.3 kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      , respectively, while those of controls were 44.6 \u00b1 12.0 years and 24.6 \u00b1 3.2 kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      , respectively. Systolic blood pressure was significantly higher in SS (124.6 \u00b1 20.8 vs. 117.0 \u00b1 18.6 mm of Hg,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.05). All SS patients were hypothyroid, and all except one were hypocortisolaemic. Triglyceride (TG) levels were significantly higher in SS patients (165.6 \u00b1 83.3 vs. 117.2 \u00b1 56.1,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.01), but no difference in the prevalence of metabolic syndrome (MetS) was found. hs-CRP (9.1 (5.2\u201318.5) vs. 1.5 (0.6\u20132.8),\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001) and IL-6 (4.9 (3.7\u20137.3) vs. 3.1 (2.0\u20134.2),\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001) were significantly higher in SS patients. CIMT was significantly increased in SS patients, but no difference in FMD was found. Echocardiography revealed no significant difference in left ventricular (LV) dimensions, interventricular thickness, posterior wall thickness, ejection fraction, LV mass and diastolic function.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>SS patients show increased cardiovascular risk with hypertension, dyslipidaemia and increased atherosclerotic and inflammatory markers.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijem.ijem_297_23","type":"journal-article","created":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T13:46:15Z","timestamp":1719495975000},"page":"260-267","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Cardiovascular Risk Factors in Sheehan\u2019s Syndrome: A Case-Control Study"],"prefix":"10.4103","volume":"28","author":[{"given":"Mayur","family":"Agrawal","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subhash C.","family":"Yadav","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swish K.","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Radiology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheo","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Radiology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krishnarpan","family":"Chatterjee","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naveen K.","family":"Garg","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,6,26]]},"reference":[{"key":"R1-20240830","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.fertnstert.2005.02.022","article-title":"Epidemiologic aspects of postpartum pituitary hypofunction (Sheehan's syndrome)","volume":"84","author":"Zargar","year":"2005","journal-title":"Fertil 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