{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:31:54Z","timestamp":1787761914927,"version":"build-2784847793"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Sheehan syndrome is a common cause of hypopituitarism in developing countries. Among risk factors, in addition to post-partum haemorrhage, a smaller sellar volume is also believed to predispose to pituitary necrosis. Some earlier studies have reported smaller sellar volume in these patients but involved a small number of patients and lacked matched controls. The main of the present study was to study the sellar volume in a large cohort of patients with Sheehan syndrome and compare it with age- and parity-matched controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Fifty women with Sheehan syndrome and an equal number of age- and parity-matched controls were studied. Baseline investigations, relevant hormonal assay, and MRI of pituitary were studied in all.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Sellar volume was significantly lower in patients with Sheehan syndrome (334.50 \u00b1 129.08 mm\n                      <jats:sup>3<\/jats:sup>\n                      in patients as against 456.64 \u00b1 169.25 mm\n                      <jats:sup>3<\/jats:sup>\n                      in controls,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.000). Far more women with Sheehan syndrome than controls had decreased sellar volume (40% vs. 12%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Patients with Sheehan syndrome have a smaller sellar volume that may be a non-modifiable risk factor for the development of post-partum pituitary necrosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijem.ijem_316_22","type":"journal-article","created":{"date-parts":[[2023,7,3]],"date-time":"2023-07-03T15:07:05Z","timestamp":1688396825000},"page":"431-435","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":4,"title":["Sella Turcica Size in Women with Sheehan Syndrome\u2014A Case\u2013Control Study"],"prefix":"10.4103","volume":"27","author":[{"given":"Bashir Ahmad","family":"Laway","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Sher-i-Kashmir Institute of Medical Sciences, Soura, Srinagar, Jammu and Kashmir, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atul","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Sher-i-Kashmir Institute of Medical Sciences, Soura, Srinagar, Jammu and Kashmir, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naseer Ahmad","family":"Choh","sequence":"additional","affiliation":[{"name":"Department of Radio Diagnosis and Imaging, Sher-i-Kashmir Institute of Medical Sciences, Soura, Srinagar, Jammu and Kashmir, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feroze","family":"Shaheen","sequence":"additional","affiliation":[{"name":"Department of Radio Diagnosis and Imaging, Sher-i-Kashmir Institute of Medical Sciences, Soura, Srinagar, Jammu and Kashmir, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arshad Iqbal","family":"Wani","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Sher-i-Kashmir Institute of Medical Sciences, Soura, Srinagar, Jammu and Kashmir, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,6,30]]},"reference":[{"key":"R1-20240828","doi-asserted-by":"crossref","first-page":"16092","DOI":"10.1038\/nrdp.2016.92","article-title":"Sheehan syndrome","volume":"2","author":"Karaca","year":"2016","journal-title":"Nat Rev Dis Primers"},{"key":"R2-20240828","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1023\/B:PITU.0000023425.20854.8e","article-title":"Sheehan's syndrome","volume":"6","author":"Kele\u015ftimur","year":"2003","journal-title":"Pituitary"},{"key":"R3-20240828","doi-asserted-by":"crossref","first-page":"996","DOI":"10.4103\/2230-8210.122608","article-title":"Pregnancy and pituitary disorders: Challenges in diagnosis and management","volume":"17","author":"Laway","year":"2013","journal-title":"Indian J Endocrinol Metab"},{"issue":"(Suppl 3)","key":"R4-20240828","doi-asserted-by":"crossref","first-page":"S203","DOI":"10.4103\/2230-8210.84869","article-title":"Sheehan's syndrome: Newer advances","volume":"15","author":"Shivaprasad","year":"2011","journal-title":"Indian J Endocrinol Metab"},{"key":"R5-20240828","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1016\/j.fertnstert.2005.04.034","article-title":"The incidence of Sheehan's syndrome after obstetric hemorrhage","volume":"84","author":"Feinberg","year":"2005","journal-title":"Fertil Steril"},{"key":"R6-20240828","first-page":"514891","article-title":"Etiopathogenesis of Sheehan's syndrome: Roles of coagulation factors and TNF-Alpha","author":"Diri","year":"2014","journal-title":"Int J Endocrinol 2014"},{"key":"R7-20240828","doi-asserted-by":"crossref","first-page":"4137","DOI":"10.1210\/jc.2001-020242","article-title":"Pituitary autoimmunity in patients with Sheehan's syndrome","volume":"87","author":"Goswami","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"key":"R8-20240828","doi-asserted-by":"crossref","first-page":"338","DOI":"10.5144\/0256-4947.1996.338","article-title":"Clinical spectrum of Sheehan's syndrome","volume":"16","author":"Zargar","year":"1996","journal-title":"Ann Saudi Med"},{"key":"R9-20240828","doi-asserted-by":"crossref","first-page":"238","DOI":"10.4103\/2230-8210.84874","article-title":"Selective preservation of anterior pituitary functions in patients with Sheehan's syndrome","volume":"15","author":"Laway","year":"2011","journal-title":"Indian J Endocrinol"},{"key":"R10-20240828","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1590\/2359-3997000000137","article-title":"Clinical, hormonal and radiological features of partial Sheehan's syndrome: An Indian experience","volume":"60","author":"Laway","year":"2016","journal-title":"Arch Endocrinol Metab"},{"key":"R11-20240828","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1590\/S0004-27302011000200010","article-title":"Sheehan's syndrome with central diabetes insipidus","volume":"55","author":"Laway","year":"2011","journal-title":"Arq Bras Endocrinol Metabol"},{"key":"R12-20240828","first-page":"660","article-title":"Sheehan's syndrome in Xinjiang: Clinical characteristics and laboratory evaluation of 97 patients","volume":"14","author":"Du","year":"2005","journal-title":"Hormones (Athens)"},{"key":"R13-20240828","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1530\/EJE-14-0244","article-title":"Extensive investigation of 114 patients with Sheehan's syndrome: A continuing disorder","volume":"171","author":"Diri","year":"2014","journal-title":"Eur J Endocrinol"},{"key":"R14-20240828","doi-asserted-by":"crossref","first-page":"259","DOI":"10.7326\/0003-4819-65-2-259","article-title":"The Sella Turcica in postpartum pituitary necrosis (Sheehan's syndrome)","volume":"65","author":"Meador","year":"1966","journal-title":"Ann Intern Med"},{"key":"R15-20240828","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1111\/j.1365-2265.1989.tb00265.x","article-title":"Sella size and contents in Sheehan's syndrome","volume":"30","author":"Sherif","year":"1989","journal-title":"Clin Endocrinol (Oxf)"},{"key":"R16-20240828","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/BF03346787","article-title":"The sella turcica in Sheehan's syndrome: Computerized tomographic study in 54 patients","volume":"14","author":"Bakiri","year":"1991","journal-title":"J Endocrinol Invest"},{"key":"R17-20240828","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.fertnstert.2005.02.022","article-title":"Epidemiologic aspects of postpartum pituitary hypofunction (Sheehan's syndrome)","volume":"84","author":"Zargar","year":"2005","journal-title":"Fertil Steril"},{"key":"R18-20240828","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1007\/s11102-014-0575-8","article-title":"Insulin resistance, metabolic syndrome and chronic low-grade inflammation in Sheehan's syndrome on standard replacement therapy: A case control study","volume":"18","author":"Bhat","year":"2015","journal-title":"Pituitary"},{"key":"R19-20240828","first-page":"989","article-title":"The volume of the sella turcica","volume":"87","author":"Di Chiro","year":"1962","journal-title":"Am J Roentgenol Radium Ther Nucl Med"},{"key":"R20-20240828","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1530\/eje.1.01881","article-title":"Sheehan's syndrome: Baseline characteristics and effect of 2 years of growth hormone replacement therapy in 91 patients in KIMS- Pfizer International Metabolic Database","volume":"152","author":"Kelestimur","year":"2015","journal-title":"Eur J Endocrinol"},{"key":"R21-20240828","doi-asserted-by":"crossref","first-page":"941","DOI":"10.3174\/ajnr.A1016","article-title":"Sequential pituitary MR imaging in Sheehan syndrome: Report of 2 cases","volume":"29","author":"Kaplun","year":"2008","journal-title":"Am J Neuroradiol"},{"key":"R22-20240828","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/0002-9343(83)90437-0","article-title":"Empty sella of normal size in Sheehan's syndrome","volume":"75","author":"Fleckman","year":"1983","journal-title":"Am J Med"},{"key":"R23-20240828","doi-asserted-by":"crossref","first-page":"79","DOI":"10.23950\/jcmk\/9268","article-title":"Comparison of sella turcica volumes among patients with primary empty sella, Sheehan syndrome and healthy individuals","volume":"6","author":"Simsek","year":"2020","journal-title":"J Clin Med Kaz"},{"key":"R24-20240828","first-page":"277","article-title":"Simmonds's disease due to post-partum necrosis of the anterior pituitary","volume":"8","author":"Sheehan","year":"1939","journal-title":"QJM"}],"container-title":["Indian Journal of Endocrinology and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ijem.ijem_316_22","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:11:47Z","timestamp":1787760707000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ijem.ijem_316_22"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,30]]},"references-count":24,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.4103\/ijem.ijem_316_22","relation":{},"ISSN":["2230-8210","2230-9500"],"issn-type":[{"value":"2230-8210","type":"print"},{"value":"2230-9500","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,30]]},"assertion":[{"value":"2022-08-11","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-02-03","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}