{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:26:09Z","timestamp":1787761569899,"version":"build-2784847793"},"reference-count":37,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Maturity onset diabetes of young (MODY) is considered to be the most underdiagnosed condition. The correct diagnosis of MODY has a definite bearing on the outcome and clinical course of the disease. We aim to determine the prevalence and clinical profile of MODY among young diabetic patients attending at Department of Endocrinology, a tertiary care institute in North India.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>It was a cross-sectional study involving all consecutive consenting patients with diabetes and age of onset \u226435 years. A total of 1,094 patients were included in this study, of whom 858 were having age of onset of diabetes &lt;25 years. All patients were screened for MODY using clinical criteria and MODY Probability calculator (available on diabetesgenes.org). Patients with high clinical probability of MODY having negative anti-GAD65 antibody and fasting serum C-peptide levels &gt;0.6 ng\/mL were subjected to the Ala98 Val polymorphism (SNP) in hepatocyte nuclear factor (HNF) 1a gene.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The prevalence of MODY among the study cohort as per clinical criteria was found to be 7.7%. Males constituted the majority of patients (male vs female, 56% vs. 44%;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001). The patients with MODY were younger (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.001), leaner (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.001), had younger age at onset of diabetes mellitus (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.001), and lower frequency of features of insulin resistance in the form of skin tags and acanthosis nigricans. Among the 40 patients who were subjected to Ala98Val polymorphism of HNF1\u03b1 gene (MODY 3), the mutant genotype was seen in 20 (50%) patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>We report a higher prevalence of MODY in our young diabetic patients. A high index of suspicion is required to diagnose MODY as misdiagnosis and inappropriate treatment may have a significant impact on quality-of-life (QOL) with increased cost and unnecessary treatment with insulin.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijem.ijem_334_22","type":"journal-article","created":{"date-parts":[[2023,2,3]],"date-time":"2023-02-03T08:26:02Z","timestamp":1675412762000},"page":"543-550","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Prevalence and Clinical Profile of Maturity Onset Diabetes of the Young among People with Diabetes Attending a Tertiary Care Centre"],"prefix":"10.4103","volume":"26","author":[{"given":"Javaid Ahmad","family":"Bhat","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Superspeciality Hospital, GMC, Srinagar, Jammu and Kashmir, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moomin Hussain","family":"Bhat","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Sher-i-Kashmir Institute of Medical Sciences, Srinagar, Jammu and Kashmir, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shariq Rashid","family":"Masoodi","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Sher-i-Kashmir Institute of Medical Sciences, Srinagar, Jammu and Kashmir, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilal","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Sher-i-Kashmir Institute of Medical Sciences, Srinagar, Jammu and Kashmir, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peerzada Ovais","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Sher-i-Kashmir Institute of Medical Sciences, Srinagar, Jammu and Kashmir, 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Jammu and Kashmir, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imtiyaz","family":"Rashid","sequence":"additional","affiliation":[{"name":"Department of Immunology, Sher-i-Kashmir Institute of Medical Sciences, Srinagar, Jammu and Kashmir, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bashir Ahmad","family":"Ganai","sequence":"additional","affiliation":[{"name":"Centre of Research for Development, University of Kashmir, Srinagar, Jammu and Kashmir, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamran","family":"Nissar","sequence":"additional","affiliation":[{"name":"Centre of Research for Development, University of Kashmir, Srinagar, Jammu and Kashmir, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zafar Amin","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Immunology, Sher-i-Kashmir Institute of Medical Sciences, Srinagar, Jammu and Kashmir, 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