{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:32:29Z","timestamp":1787761949226,"version":"build-2784847793"},"reference-count":11,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,7]]},"abstract":"Abstract<\/jats:title>\n \n Introduction:<\/jats:title>\n Congenital adrenal hyperplasia (CAH) is a rare autosomal recessive disorder requiring treatment with steroids. Both over and under-treatment can have an impact on growth outcomes.<\/jats:p>\n <\/jats:sec>\n \n Aims:<\/jats:title>\n The aim of this study was to study the clinical and hormonal profile of a cohort of individuals with classical 21-hydroxylase CAH and to assess the factors influencing growth outcomes in these individuals.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n In this cross-sectional study, individuals with classical CAH were included. Baseline data were obtained from electronic medical records. Anthropometric measurements and hormonal profiles were assessed. Quantitative variables were expressed as mean \u00b1 standard deviation or median (interquartile range) and qualitative variables as percentages. To measure the correlation between variables, Spearman\u2019s rank correlation was used.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Of the 27 patients with classical 21-hydroxylase CAH, 13 had salt wasting and 14 had simple virilizing phenotype. The median height standard deviation score (SDS) of the cohort was -1 SDS (-2.00 to 0.2) with 24% having short stature (height < -2 SDS). There was no significant difference in height SDS depending on the age, gender, type of CAH or onset of central precocious puberty. There was no significant correlation between glucocorticoid dose and height SDS (\n r<\/jats:italic>\n = 0.104). Obesity was a common finding (40% adults, 41.1% children). However, there was no significant correlation between BMI and glucocorticoid dose (\n r<\/jats:italic>\n = 0.419).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n Short stature was a significant finding as noted in earlier studies. However, the high prevalence of obesity was a new finding that could not be explained by the dose of steroids alone.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/ijem.ijem_337_22","type":"journal-article","created":{"date-parts":[[2023,7,3]],"date-time":"2023-07-03T15:06:28Z","timestamp":1688396788000},"page":"413-416","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Clinical and Hormonal Profile of Classical 21-Hydroxylase Deficiency Congenital Adrenal Hyperplasia: Experience from a Tertiary Centre In India"],"prefix":"10.4103","volume":"28","author":[{"given":"Harshitha","family":"Boyareddy","sequence":"first","affiliation":[{"name":"Department of Endocrinology, M S Ramaiah Medical College, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pramila","family":"Kalra","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, M S Ramaiah Medical College, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mala","family":"Dharmalingam","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, M S Ramaiah Medical College, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,6,30]]},"reference":[{"key":"R1-20240828","first-page":"245","article-title":"Congenital adrenal hyperplasia due to 21-hydroxylase deficiency","volume":"21","author":"White","year":"2000","journal-title":"Endocr Rev"},{"key":"R2-20240828","doi-asserted-by":"crossref","first-page":"4043","DOI":"10.1210\/jc.2018-01865","article-title":"Congenital adrenal hyperplasia due to steroid 21-hydroxylase deficiency: An endocrine society clinical practice","volume":"103","author":"Speiser","year":"2018","journal-title":"J Clin Endocrinol Metab"},{"key":"R3-20240828","first-page":"2958","article-title":"Lessons from 30 years of clinical diagnosis and treatment of congenital adrenal hyperplasia in five middle European countries","volume":"86","author":"Kovacs","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"key":"R4-20240828","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1007\/s12098-018-02848-6","article-title":"Growth pattern and clinical profile of indian children with classical 21-Hydroxylase deficiency congenital adrenal hyperplasia on treatment","volume":"86","author":"Meena","year":"2019","journal-title":"Indian J Pediatr"},{"key":"R5-20240828","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1111\/j.1440-1754.2011.02104.x","article-title":"Congenital adrenal hyperplasia: An Indian experience","volume":"47","author":"Maiti","year":"2011","journal-title":"J Paediatr Child Health"},{"key":"R6-20240828","first-page":"1226","article-title":"21-Hydroxylase deficiency: Clinical features, laboratory profile, and pointers to diagnosis in Indian children","volume":"41","author":"Bajpai","year":"2004","journal-title":"Indian Pediatr"},{"key":"R7-20240828","doi-asserted-by":"crossref","first-page":"624507","DOI":"10.3389\/fendo.2021.624507","article-title":"Analysis of the screening results for congenital adrenal hyperplasia involving 7.85 million newborns in China: A systematic review and meta-analysis","volume":"12","author":"Li","year":"2021","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"Suppl 2","key":"R8-20240828","doi-asserted-by":"crossref","first-page":"S385","DOI":"10.4103\/2230-8210.104102","article-title":"Congenital adrenal hyperplasia - Experience from a tertiary center in South India","volume":"16","author":"Belinda","year":"2012","journal-title":"Indian J Endocrinol Metab"},{"key":"R9-20240828","first-page":"284","article-title":"How many deaths can be prevented by newborn screening for congenital adrenal hyperplasia?","volume":"67","author":"Grosse","year":"2007","journal-title":"Horm Res"},{"key":"R10-20240828","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1007\/s12098-018-2645-9","article-title":"Newborn screening for congenital hypothyroidism and congenital adrenal hyperplasia","volume":"85","year":"2018","journal-title":"Indian J Pediatr"},{"key":"R11-20240828","first-page":"SC06","article-title":"Clinical profile, predictors of death and anthropometric follow-up in neonates with classical 21-Hydroxylase deficiency","volume":"12","author":"Rajendran","year":"2018","journal-title":"J Clin Diagn Res"}],"container-title":["Indian Journal of Endocrinology and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ijem.ijem_337_22","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:11:37Z","timestamp":1787760697000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ijem.ijem_337_22"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,30]]},"references-count":11,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.4103\/ijem.ijem_337_22","relation":{},"ISSN":["2230-8210","2230-9500"],"issn-type":[{"value":"2230-8210","type":"print"},{"value":"2230-9500","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,30]]},"assertion":[{"value":"2022-08-31","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-02-15","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}